DegronMD

Uniprot ID: Q9Y462

Source protein: Zinc finger protein 711

Source gene: ZNF711

Class: DEG_SCF_TRCP1_1

Location: 2:7

E3 ligase: BTRC

DEGRON score: 0.9877

ASA_SCORE: 65.1667

COIL: 0.8972

CONS_SCORE: 0.7979

DSS_SCORE: 0.8432

HELIX: 0.0323

FCONS_SCORE: 1.0687

RIG_SCORE: 0.568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13A	TCGA-60-2711	LUSC	TCGA	DSGGGS	DEG_SCF_TRCP1_1	0.1667
p.P13A	DO26987	LUSC	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.1667
p.R16I	TCGA-CN-4741	HNSC	TCGA	DSGGGS	DEG_SCF_TRCP1_1	0.0833
p.R16I	DO14313	HNSC	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.0833
p.D2N	TCGA-D3-A51T	SKCM	TCGA	DSGGGS	DEG_SCF_TRCP1_1	0.6932
p.D2N	DO47389	SKCM	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.6932
p.G5V	TCGA-DS-A5RQ	CESC	TCGA	DSGGGS	DEG_SCF_TRCP1_1	0.6421
p.G5V	DO44392	CESC	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.6421
p.R16T	TCGA-J1-A4AH	LUSC	TCGA	DSGGGS	DEG_SCF_TRCP1_1	0.0833
p.R16T	DO45479	LUSC	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.0833
p.M17V	DO228542	GACA	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.0556
p.G5C	DO229027	LICA	ICGC	DSGGGS	DEG_SCF_TRCP1_1	0.6489
p.G6V	ACH-000681	Lung Cancer	CCLE	DSGGGS	DEG_SCF_TRCP1_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T37	RNA-binding protein 15	DEG_SCF_TRCP1_1	89:94	DSGGGS	BTRC	0.9617	More...
Q9Y462	Zinc finger protein 711	DEG_SCF_TRCP1_1	2:7	DSGGGS	BTRC	0.9877	More...
Q6NY19	KN motif and ankyrin repeat domain-containing protein 3	DEG_SCF_TRCP1_1	509:514	DSGGGS	BTRC	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons