DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2674:2680

E3 ligase: FBXW7

DEGRON score: 0.9558

ASA_SCORE: 91.0286

COIL: 0.9513

CONS_SCORE: 0.2632

DSS_SCORE: 0.6466

HELIX: 0.0166

FCONS_SCORE: 1.0611

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2682H	TCGA-E9-A1ND	BRCA	TCGA	MATPSSS	DEG_SCF_FBW7_1	0.2778
p.S2689P	TCGA-IB-7651	PAAD	TCGA	MATPSSS	DEG_SCF_FBW7_1	0.0833
p.Q2685H	DO5780	BRCA	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.1944
p.A2678S	DO229221	THCA	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.7588
p.L2690M	SIDM00660	Colorectal Carcinoma	GDSC	MATPSSS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons