DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4664:4670

E3 ligase: FBXW7

DEGRON score: 0.94

ASA_SCORE: 89.8

COIL: 0.9493

CONS_SCORE: 0.3131

DSS_SCORE: 0.6436

HELIX: 0.0203

FCONS_SCORE: 0.9487

RIG_SCORE: 0.6531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4674N	TCGA-AX-A3G9	UCEC	TCGA	MATPSSS	DEG_SCF_FBW7_1	0.2222
p.S4669F	TCGA-YG-AA3N	SKCM	TCGA	MATPSSS	DEG_SCF_FBW7_1	0.6871
p.T4657N	DO23592	LUAD	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.1389
p.S4672C	DO231179	LUSC	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.2778
p.S4672F	DO51298	SKCM	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.2778
p.T4657A	DO229216	THCA	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.1389
p.S4677N	DO41241	UCEC	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons