DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3931:3937

E3 ligase: FBXW7

DEGRON score: 0.8063

ASA_SCORE: 86.5429

COIL: 0.8956

CONS_SCORE: 0.2692

DSS_SCORE: 0.6383

HELIX: 0.017

FCONS_SCORE: 1.0461

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3923S	TCGA-34-5929	LUSC	TCGA	MATPSSS	DEG_SCF_FBW7_1	0.1111
p.S3930F	TCGA-ZF-AA4X	BLCA	TCGA	MATPSSS	DEG_SCF_FBW7_1	0.3056
p.S3933F	DO219091	BLCA	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.7982
p.T3926S	DO26659	LUSC	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.1944
p.A3930S	DO229245	THCA	ICGC	MATPSSS	DEG_SCF_FBW7_1	0.3056
p.Q3939E	SIDM00680	Colorectal Carcinoma	GDSC	MATPSSS	DEG_SCF_FBW7_1	0.2778
p.Q3939E	ACH-000957	Colon/Colorectal Cancer	CCLE	MATPSSS	DEG_SCF_FBW7_1	0.2778
p.Q3939E	LS-180	large_intestine	COSMIC	MATPSSS	DEG_SCF_FBW7_1	0.2778
p.M3931T	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	MATPSSS	DEG_SCF_FBW7_1	0.7423
p.M3931T	ACH-000757	Lung Cancer	CCLE	MATPSSS	DEG_SCF_FBW7_1	0.7423
p.M3931T	A427	lung	COSMIC	MATPSSS	DEG_SCF_FBW7_1	0.7423
p.T3943A	SIDM00683	Prostate Carcinoma	GDSC	MATPSSS	DEG_SCF_FBW7_1	0.1667
p.V3926E	SIDM00954	Breast Carcinoma	GDSC	MATPSSS	DEG_SCF_FBW7_1	0.1944
p.V3926E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	MATPSSS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons