DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1638:1645

E3 ligase: FBXW7

DEGRON score: 0.8275

ASA_SCORE: 86.6125

COIL: 0.9259

CONS_SCORE: 0.5236

DSS_SCORE: 0.5545

HELIX: 0.0109

FCONS_SCORE: 1

RIG_SCORE: 0.6832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1632P	TCGA-34-2604	LUSC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.L1632P	DO26433	LUSC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.T1634I	TCGA-B5-A0K4	UCEC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2222
p.T1634I	DO42360	UCEC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2222
p.S1645N	TCGA-B6-A1KN	BRCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.7069
p.S1645N	DO3656	BRCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7069
p.T1640A	TCGA-BR-6452	STAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.6028
p.T1640A	DO38404	STAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6028
p.S1645I	TCGA-DX-A8BT	SARC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S1645I	DO220063	SARC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S1645I	SIDM00231	Kidney Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S1645I	NCC010	kidney	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.G1629E	TCGA-EE-A29M	SKCM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.G1629E	DO37404	SKCM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.P1637L	TCGA-EE-A2A0	SKCM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P1637L	DO37439	SKCM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.A1648T	TCGA-FW-A3R5	SKCM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.25
p.A1648T	DO37406	SKCM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.25
p.L1632V	TCGA-SW-A7EA	STAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.L1632V	DO51749	STAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.S1645T	TCGA-XQ-A8TA	PRAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.6005
p.S1645T	DO223662	PRAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6005
p.T1640N	DO234284	ESAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5944
p.I1636M	DO229030	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.I1636V	DO229058	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.P1631L	SIDM00967	Ovarian Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.P1631L	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.S1639N	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.5958
p.S1639N	ACH-000030	Lung Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.5958
p.S1639N	ACH-000779	Lung Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.5958
p.S1639N	PC-14	lung	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.5958
p.V1638L	AM-38	central_nervous_system	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.5654

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVAS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	459:466	VSTTPVAS	FBXW7	0.9242	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1638:1645	VSTTPVAS	FBXW7	0.8275	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2522:2529	VSTTPVAS	FBXW7	0.5134	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2876:2883	VSTTPVAS	FBXW7	0.8723	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3524:3531	VSTTPVAS	FBXW7	0.7712	More...