DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3524:3531

E3 ligase: FBXW7

DEGRON score: 0.7712

ASA_SCORE: 84.35

COIL: 0.8369

CONS_SCORE: 0.5236

DSS_SCORE: 0.5861

HELIX: 0.0168

FCONS_SCORE: 1

RIG_SCORE: 0.7032

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3532P	TCGA-B5-A0JY	UCEC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.S3532P	DO43041	UCEC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.T3539I	TCGA-EJ-7782	PRAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.T3539I	DO36256	PRAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.T3539I	SIDM00660	Colorectal Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.T3539I	ACH-000985	Colon/Colorectal Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.T3539I	LS-411N	large_intestine	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.T3539K	TCGA-XF-A8HF	BLCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.T3539K	DO49800	BLCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.S3532C	TCGA-Z6-AAPN	ESCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.T3540S	DO1110	BRCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.T3526N	DO222907	BTCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5944
p.M3522I	DO229060	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.P3528L	DO229062	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P3528L	SIDM00510	Small Cell Lung Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P3528L	SIDM01110	Hepatocellular Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P3528L	SIDM00265	Ewing's Sarcoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P3528L	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.G3515R	DO45237	LIRI	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.S3538L	DO51050	PRAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.T3527I	SIDM00553	Acute Myeloid Leukemia	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7078
p.T3527I	SIDM01653	Non-Cancerous	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7078
p.T3527I	SIDM00207	Glioblastoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7078
p.T3527I	SIDM01511	Gastric Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7078
p.V3529E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.6582
p.V3529E	ACH-000916	Lung Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.6582
p.V3529E	NCI-H1573	lung	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.6582
p.A3530V	SIDM01435	Hepatocellular Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.5825
p.T3526P	ACH-000679	Esophageal Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.5919
p.T3526P	OE19	oesophagus	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVAS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	459:466	VSTTPVAS	FBXW7	0.9242	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1638:1645	VSTTPVAS	FBXW7	0.8275	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2522:2529	VSTTPVAS	FBXW7	0.5134	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2876:2883	VSTTPVAS	FBXW7	0.8723	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3524:3531	VSTTPVAS	FBXW7	0.7712	More...