DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2522:2529

E3 ligase: FBXW7

DEGRON score: 0.5134

ASA_SCORE: 86.1125

COIL: 0.8895

CONS_SCORE: 0.5236

DSS_SCORE: 0.4737

HELIX: 0.0089

FCONS_SCORE: 1

RIG_SCORE: 0.7081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2535F	TCGA-A6-6781	COAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.L2535F	DO8447	COAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.S2536P	TCGA-AG-3902	READ	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.S2536P	DO36407	READ	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.A2528V	TCGA-D8-A1XQ	BRCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.5825
p.A2528V	DO3095	BRCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5825
p.E2531D	TCGA-DU-6392	LGG	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2531D	DO22237	LGG	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2512K	TCGA-E7-A541	BLCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.E2512K	DO44037	BLCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.E2531Q	TCGA-FD-A3B3	BLCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2531Q	DO749	BLCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.T2525M	TCGA-MA-AA3Y	CESC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2525M	TCGA-MP-A4T7	LUAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2525M	DO219721	CESC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2525M	DO234413	ESAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2525M	DO48221	ESCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.T2525M	DO45370	LUAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7423
p.I2520M	DO227427	EOPC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.T2538P	DO234212	ESAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.S2529I	SIDM01190	Bladder Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S2529I	ACH-000720	Bladder Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.7341
p.S2529I	TCCSUP	urinary_tract	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.7341

DegronMD: protein-targeted degradation, mutation and drug response to degrons