DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 2876:2883

E3 ligase: FBXW7

DEGRON score: 0.8723

ASA_SCORE: 87.325

COIL: 0.9141

CONS_SCORE: 0.5236

DSS_SCORE: 0.445

HELIX: 0.0159

FCONS_SCORE: 1

RIG_SCORE: 0.725

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2880Q	TCGA-44-2657	LUAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.7035
p.P2880Q	DO25020	LUAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7035
p.S2877G	TCGA-76-6660	GBM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.5882
p.S2877G	DO222737	COCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5882
p.S2877G	DO223728	GBM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5882
p.V2881M	TCGA-A3-A8OW	KIRC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.6097
p.V2881M	DO219233	KIRC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6097
p.T2869A	TCGA-AA-3811	COAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.T2869A	DO7962	COAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.A2886D	TCGA-BS-A0UF	UCEC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.25
p.A2886D	DO41488	UCEC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.25
p.E2885K	TCGA-CN-4723	HNSC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2885K	DO14830	HNSC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2885K	SIDM01322	Oral Cavity Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2885K	ACH-000735	Head and Neck Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.S2890L	TCGA-D3-A8GI	SKCM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.S2890L	DO50284	SKCM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1389
p.G2867E	TCGA-EE-A2GI	SKCM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.G2867E	DO37410	SKCM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.E2885Q	TCGA-FD-A6TC	BLCA	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E2885Q	DO49755	BLCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.S2868C	TCGA-SX-A7SP	KIRP	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.S2868C	DO49790	KIRP	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.P2875L	DO52611	BOCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2880L	DO52481	COCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	DO229346	LAML	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	DO229052	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	SIDM00234	Other Solid Cancers	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	SIDM00377	Other Sarcomas	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	SIDM00655	Other Solid Cancers	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	SIDM01033	Bladder Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	SKN	soft_tissue	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	KU-19-19	urinary_tract	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	TC-YIK	cervix	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.P2880L	NCCIT	testis	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.7582
p.S2873I	DO228948	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.25
p.S2884P	DO228960	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.S2884P	SIDM02064	Colorectal Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.A2882V	DO229050	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5825
p.L2870P	DO229061	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1667
p.G2867R	DO222868	MELA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.P2875S	DO47243	RECA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P2880S	SIDM00660	Colorectal Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.P2880S	ACH-000985	Colon/Colorectal Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.P2880S	LS-411N	large_intestine	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.P2893H	SIDM00217	Colorectal Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.P2893H	ACH-000999	Colon/Colorectal Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.P2893H	SNU-1040	large_intestine	COSMIC	VSTTPVAS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVAS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	459:466	VSTTPVAS	FBXW7	0.9242	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1638:1645	VSTTPVAS	FBXW7	0.8275	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2522:2529	VSTTPVAS	FBXW7	0.5134	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2876:2883	VSTTPVAS	FBXW7	0.8723	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3524:3531	VSTTPVAS	FBXW7	0.7712	More...