DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 459:466

E3 ligase: FBXW7

DEGRON score: 0.9242

ASA_SCORE: 83.375

COIL: 0.8374

CONS_SCORE: 0.5236

DSS_SCORE: 0.6225

HELIX: 0.0169

FCONS_SCORE: 0.9898

RIG_SCORE: 0.6736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E468Q	TCGA-18-3406	LUSC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.E468Q	DO26438	LUSC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.P463T	TCGA-50-5933	LUAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.7031
p.P463T	DO24800	LUAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7031
p.P463S	TCGA-A5-A0G2	UCEC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.P463S	DO41235	UCEC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6752
p.M457I	TCGA-BB-8596	HNSC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.M457I	DO15599	HNSC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.M457I	DO229036	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.2778
p.A465T	TCGA-BR-8081	STAD	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.6028
p.A465T	DO38795	STAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6028
p.S451R	TCGA-BS-A0UV	UCEC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.S451R	DO42793	UCEC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.S467Y	TCGA-D1-A103	UCEC	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.S467Y	DO42312	UCEC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.3056
p.P476S	TCGA-FR-A726	SKCM	TCGA	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.P476S	DO48665	SKCM	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.S451N	DO230326	COCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1111
p.A465S	DO222755	COCA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6477
p.A465S	DO229015	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.6477
p.S466R	DO50407	ESAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.7427
p.G450V	DO234369	ESAD	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.0833
p.N471T	DO229030	LICA	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.1944
p.A465V	DO230990	LUSC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5825
p.A465V	DO224554	LUSC	ICGC	VSTTPVAS	DEG_SCF_FBW7_1	0.5825
p.E449K	SIDM01611	Endometrial Carcinoma	GDSC	VSTTPVAS	DEG_SCF_FBW7_1	0.0556
p.E449K	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSTTPVAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	459:466	VSTTPVAS	FBXW7	0.9242	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1638:1645	VSTTPVAS	FBXW7	0.8275	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2522:2529	VSTTPVAS	FBXW7	0.5134	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	2876:2883	VSTTPVAS	FBXW7	0.8723	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3524:3531	VSTTPVAS	FBXW7	0.7712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVAS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVAS