Gene: Ift88

Basic information

Tag Content
Uniprot ID A0A096MK92
Entrez ID 305918
Genbank protein ID
Genbank nucleotide ID XM_017599687.1; XM_006252066.3; XM_006252067.3; XM_006252068.3;
Ensembl protein ID ENSRNOP00000068425
Ensembl nucleotide ID ENSRNOG00000009278
Gene name Intraflagellar transport 88
Gene symbol Ift88
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MMENVHLAPE TDEDDLYSGF NDYNPAYDTE ELENDTGFQQ AVRTSHGRRP PVTAKIPSTA 60
VSRPIATGYG SKTSLTSSMG RPMTGTIQDG VARPMTAVRA AGFSKAALRG SAFDPLGQSR 120
GPAPPLEAKN EDSPEEKIRQ LEKKVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR 180
QREQVTSPEN INLDLTYSVL FNLASQYSAN EMYAEALNTY QVIVKNKMFS NAGRLKVNMG 240
NIYLKQRNYS KAIKFYRMAL DQIPSVHKEM RIKIMQNIGI TFIKTGQYSD AINSFEHIMS 300
MAPSLKAGFN LILSCFAIGD REKMKKAFQK LIAVPLEIDE DDKYISPSDD PHTNLLIEAI 360
KNDHLRQMER ERKAMAEKYI MTAAKLIAPV IEASFAVGYN WCVEVVKASQ YVELANDLEI 420
NKAITYLRQK DFNQAVDTLK MFEKKDSRVK SAAATNLSFL YYLENEFAQA SSYADLAVSS 480
DRYNPSALTN KGNTVFANGD YEKAAEFYKE ALRNDSSCTE ALYNIGLTYK KLNRLDEALD 540
SFLKLHAILR NSAQVLCQIA NVYELMEDPN QAIEWLMQLI SVVPTDSQAL SKLGELYDSE 600
GDKSQAFQYY YESYRYFPSN IEVIEWLGAY YIDTQFCEKA IQYFERASLI QPTQVKWQLM 660
VASCFRRSGN YQKALDTYKE IHRKFPENVE CLRFLVRLCT DIGLKEVQEY ATKLKRLEKM 720
KEMREQRIKS GRDSGGGSRS KREGSAGSDS GQNSSASSKS ERLSAKLRAL PGTDEPYESS 780
GNKEIDASYV DPLGPQIERP KTAARKRIDE DDFADEELGD DLLPE 825

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologIFT88514177E1BLX1Bos taurusPredictionMore>>
1:1 orthologIFT88477345E2R838Canis lupus familiarisPredictionMore>>
1:1 orthologIFT88A0A452FFN1Capra hircusPredictionMore>>
1:1 orthologIFT888100Q13099Homo sapiensPredictionMore>>
1:1 orthologIft8821821Q61371CPO,CLP,CLOMus musculusPublicationMore>>
1:1 orthologIFT88A0A2I3RWX3Pan troglodytesPredictionMore>>
1:1 orthologI3LER9Sus scrofaPredictionMore>>
1:1 orthologIFT88100009576G1SJN9Oryctolagus cuniculusPredictionMore>>
1:1 orthologIft88305918A0A096MK92Rattus norvegicusPredictionMore>>
1:1 orthologift88B0UYB0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0002080 acrosomal membrane
GO:0097541 axonemal basal plate
GO:0005930 axoneme
GO:0005814 centriole
GO:0005813 centrosome
GO:0036064 ciliary basal body
GO:0097546 ciliary base
GO:0097542 ciliary tip
GO:0005929 cilium
GO:0005737 cytoplasm
GO:0030992 intraciliary transport particle B
GO:0060091 kinocilium
GO:0031514 motile cilium
GO:0097730 non-motile cilium
GO:0032391 photoreceptor connecting cilium
GO:0036126 sperm flagellum
GO:0019894 kinesin binding
GO:0009887 animal organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0007420 brain development
GO:0055007 cardiac muscle cell differentiation
GO:0060411 cardiac septum morphogenesis
GO:0060271 cilium assembly
GO:0090102 cochlea development
GO:0031122 cytoplasmic microtubule organization
GO:0007368 determination of left/right symmetry
GO:0009953 dorsal/ventral pattern formation
GO:0042733 embryonic digit morphogenesis
GO:0001886 endothelial cell morphogenesis
GO:0036334 epidermal stem cell homeostasis
GO:0008544 epidermis development
GO:0001654 eye development
GO:0048853 forebrain morphogenesis
GO:0007507 heart development
GO:0060914 heart formation
GO:0060122 inner ear receptor cell stereocilium organization
GO:0042073 intraciliary transport
GO:0001822 kidney development
GO:0060173 limb development
GO:0001889 liver development
GO:0030324 lung development
GO:0060426 lung vasculature development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0007399 nervous system development
GO:0061351 neural precursor cell proliferation
GO:1905515 non-motile cilium assembly
GO:0007219 Notch signaling pathway
GO:0031016 pancreas development
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:1903929 primary palate development
GO:0008104 protein localization
GO:2000785 regulation of autophagosome assembly
GO:1902017 regulation of cilium assembly
GO:0045598 regulation of fat cell differentiation
GO:0060259 regulation of feeding behavior
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0070613 regulation of protein processing
GO:0034405 response to fluid shear stress
GO:0007224 smoothened signaling pathway
GO:0007288 sperm axoneme assembly
GO:0007290 spermatid nucleus elongation
GO:0021513 spinal cord dorsal/ventral patterning
GO:0021537 telencephalon development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0802 TPR repeat

Interpro

InterPro ID InterPro Term
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

PROSITE

PROSITE ID PROSITE Term
PS50005 TPR
PS50293 TPR_REGION

Pfam

Pfam ID Pfam Term
PF13174 TPR_6
PF13181 TPR_8