| Tag | Content |
|---|---|
| Uniprot ID | Q61371; E9QKU0; Q3UXY9; Q921J5; |
| Entrez ID | 21821 |
| Genbank protein ID | BAE22424.1; AAH12250.1; AAB59705.1; |
| Genbank nucleotide ID | NM_009376.2 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Intraflagellar transport protein 88 homolog |
| Gene symbol | Ift88 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP,CLO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 12701101; 28069795; 22228099; 27802276; 28346501; |
| Functional description | Involved in primary cilium biogenesis (PubMed:31761534, PubMed:11062270, PubMed:21289087). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. |
| Sequence | MENVHLAPET DEDDLYSGFN DYNPAYDTEE LENDTGFQQA VRTSHGRRPP VTAKIPSTAV 60 SRPIATGYGS KTSLTSSMGR PMTGTIQDGV ARPMTAVRAA GFSKAALRGS AFDPLGQSRG 120 PAPPLEAKNE DSPEEKIRQL EKKVNELVEE SCIANSCGDL KLALEKAKDA GRKERVLVRQ 180 REQVTSPENI NLDLTYSVLF NLASQYSANE MYAEALNTYQ VIVKNKMFSN AGRLKVNMGN 240 IYLKQRNYSK AIKFYRMALD QIPSVHKEMR IKIMQNIGIT FIKTGQYSDA INSFEHIMSM 300 APSLKAGFNL ILSCFAIGDR EKMKKAFQKL IAVPLEIDED DKYISPSDDP HTNLLIEAIK 360 NDHLRQMERE RKAMAEKYIM TAAKLIAPVI EASFAVGYNW CVEVVKASQY VELANDLEIN 420 KAITYLRQKD FNQAVDTLKM FEKKDSRVKS AAATNLSFLY YLENEFAQAS SYADLAVNSD 480 RYNPSALTNK GNTVFANGDY EKAAEFYKEA LRNDSSCTEA LYNIGLTYKK LNRLDEALDS 540 FLKLHAILRN SAQVLCQIAN IYELMEDPNQ AIEWLMQLIS VVPTDSQALS KLGELYDSEG 600 DKSQAFQYYY ESYRYFPSNI EVIEWLGAYY IDTQFCEKAI QYFERASLIQ PTQVKWQLMV 660 ASCFRRSGNY QKALDTYKEI HRKFPENVEC LRFLVRLCTD IGLKEVQEYA TKLKRLEKMK 720 EMREQRIKSG RDSSGGSRSK REGSAGSDSG QNNSASSKSE RLSAKLRALP GTDEPYESSG 780 NKEIDASYVD PLGPQIERPK TAAKKRIDED DFADEELGDD LLPE 824 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IFT88 | 514177 | E1BLX1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | IFT88 | 477345 | E2R838 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | IFT88 | A0A452FFN1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | IFT88 | 8100 | Q13099 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ift88 | 21821 | Q61371 | CPO,CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | IFT88 | A0A2I3RWX3 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | I3LER9 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | IFT88 | 100009576 | G1SJN9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ift88 | 305918 | A0A096MK92 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ift88 | B0UYB0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0019894 | kinesin binding | IPI |
| GO:0019894 | kinesin binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001654 | eye development | IGI |
| GO:0001822 | kidney development | IMP |
| GO:0001822 | kidney development | IBA |
| GO:0001886 | endothelial cell morphogenesis | IMP |
| GO:0001889 | liver development | IMP |
| GO:0007219 | Notch signaling pathway | IMP |
| GO:0007224 | smoothened signaling pathway | IGI |
| GO:0007224 | smoothened signaling pathway | IMP |
| GO:0007288 | sperm axoneme assembly | IMP |
| GO:0007290 | spermatid nucleus elongation | IMP |
| GO:0007368 | determination of left/right symmetry | IMP |
| GO:0007399 | nervous system development | IMP |
| GO:0007420 | brain development | IMP |
| GO:0007420 | brain development | IGI |
| GO:0007507 | heart development | IGI |
| GO:0008104 | protein localization | IMP |
| GO:0008544 | epidermis development | IMP |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0009953 | dorsal/ventral pattern formation | IMP |
| GO:0021513 | spinal cord dorsal/ventral patterning | IMP |
| GO:0021537 | telencephalon development | IMP |
| GO:0030324 | lung development | IMP |
| GO:0031016 | pancreas development | IMP |
| GO:0031122 | cytoplasmic microtubule organization | IMP |
| GO:0034405 | response to fluid shear stress | IMP |
| GO:0036334 | epidermal stem cell homeostasis | IMP |
| GO:0042073 | intraciliary transport | IBA |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth | IMP |
| GO:0042733 | embryonic digit morphogenesis | IMP |
| GO:0042733 | embryonic digit morphogenesis | IGI |
| GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway | IMP |
| GO:0045598 | regulation of fat cell differentiation | IMP |
| GO:0048853 | forebrain morphogenesis | IMP |
| GO:0050680 | negative regulation of epithelial cell proliferation | IMP |
| GO:0055007 | cardiac muscle cell differentiation | IMP |
| GO:0060122 | inner ear receptor cell stereocilium organization | IGI |
| GO:0060122 | inner ear receptor cell stereocilium organization | IMP |
| GO:0060122 | inner ear receptor cell stereocilium organization | IBA |
| GO:0060173 | limb development | IGI |
| GO:0060259 | regulation of feeding behavior | IMP |
| GO:0060271 | cilium assembly | IMP |
| GO:0060411 | cardiac septum morphogenesis | IMP |
| GO:0060426 | lung vasculature development | IMP |
| GO:0060914 | heart formation | IMP |
| GO:0061351 | neural precursor cell proliferation | IMP |
| GO:0070613 | regulation of protein processing | IMP |
| GO:0090102 | cochlea development | IGI |
| GO:1902017 | regulation of cilium assembly | IMP |
| GO:1903929 | primary palate development | IGI |
| GO:1905515 | non-motile cilium assembly | IMP |
| GO:1905515 | non-motile cilium assembly | IBA |
| GO:2000785 | regulation of autophagosome assembly | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002080 | acrosomal membrane | IDA |
| GO:0002081 | outer acrosomal membrane | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005802 | trans-Golgi network | ISO |
| GO:0005813 | centrosome | ISO |
| GO:0005813 | centrosome | IDA |
| GO:0005814 | centriole | ISO |
| GO:0005814 | centriole | IDA |
| GO:0005814 | centriole | IBA |
| GO:0005929 | cilium | ISO |
| GO:0005929 | cilium | IDA |
| GO:0005929 | cilium | TAS |
| GO:0005930 | axoneme | IDA |
| GO:0030992 | intraciliary transport particle B | IDA |
| GO:0031514 | motile cilium | IDA |
| GO:0032391 | photoreceptor connecting cilium | IDA |
| GO:0036064 | ciliary basal body | ISO |
| GO:0036064 | ciliary basal body | IDA |
| GO:0036064 | ciliary basal body | IBA |
| GO:0036126 | sperm flagellum | IDA |
| GO:0060091 | kinocilium | IDA |
| GO:0097541 | axonemal basal plate | IDA |
| GO:0097542 | ciliary tip | IDA |
| GO:0097546 | ciliary base | IDA |
| GO:0097546 | ciliary base | IBA |
| GO:0097730 | non-motile cilium | IDA |
| GO:0097730 | non-motile cilium | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-1632852 | Macroautophagy | IEA |
| R-MMU-1852241 | Organelle biogenesis and maintenance | IEA |
| R-MMU-5358351 | Signaling by Hedgehog | IEA |
| R-MMU-5610787 | Hedgehog 'off' state | IEA |
| R-MMU-5617833 | Cilium Assembly | IEA |
| R-MMU-5620924 | Intraflagellar transport | IEA |
| R-MMU-9612973 | Autophagy | IEA |
| R-MMU-9646399 | Aggrephagy | IEA |
| R-MMU-9663891 | Selective autophagy | IEA |