| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2K4L4 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000073088 |
| Ensembl nucleotide ID | ENSRNOG00000055010 |
| Gene name | Axin-2 |
| Gene symbol | Axin2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPVSSNARRN EDGLGEPEGR ASPDSPLTRW TKSLHSLLGD QDGAYLFRTF LEREKCVDTL 60 DFWFACNGFR QMNLKDTKTL RVAKAIYKRY IENNSVVSKQ LKPATKTYIR DGIKKQQIGS 120 VMFDQAQTEI QAVMEENAYQ VFLTSDIYLE YVRSGGENTA YMSNGGLGSL KVLCGYLPTL 180 NEEEEWTCAD LKCKLSPTVV GLSSKTLRAT ASVRSTETAE NGFRSFKRSE PVNPYHVGSG 240 YVFAPATSAN DSELSSDALT DDSMSMTDSS VDGIPPYRMG SKKQLQREMH RSVKANGQVS 300 LPHFPRTHRL PKEMTPVEPA AFAAELISRL EKLKLELESR HSLEERLQQI REDEEKEGSE 360 QALSSRDGAP VQHPLALLPS GSYEEDPQTI LDDHLSRVLK TPGCQSPGVG RYSPRSRSPD 420 HHHHHHQQCH ALLPTGGKLP PEAACPLLGG KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE 480 AEATQRVRCL CPGGTDYYCY SKCKSHSKPP EPLPGEQFCG SRGGTLPKRN TKGTEPGLAL 540 PAREGGMSSA AGAPQLPGEE GDRSQDVWQW MLESERQSKS KPHSTQSIRK SYPLESARAP 600 PGERVSRHHL LGASGHPRSA ARAHPFTQDP AMPPLTPPNT LAQLEEACRR LAEVSKPQKQ 660 RCCVASQQRD RNHPATGQAG PTSFSNPSLA SEDHKEPKRL ASVHALQASE LIVTYFFCGE 720 EIPYRRMLKA QSLTLGHFKE QLSKKGNYRY YFKKASDEFA CGAVFEEIWD DETVLPMYEG 780 RILGKVERID |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AXIN2 | 490903 | E2R9F8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 102180348 | A0A452FEH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 8313 | Q9Y2T1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Axin2 | 12006 | O88566 | E13.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | AXIN2 | 468301 | A0A2I3SZU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | A0A287BFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Axin2 | A0A0G2K4L4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | axin2 | 58080 | P57095 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005813 | centrosome |
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0070411 | I-SMAD binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0030282 | bone mineralization |
| GO:0008283 | cell population proliferation |
| GO:0034613 | cellular protein localization |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO:0001957 | intramembranous ossification |
| GO:0043570 | maintenance of DNA repeat elements |
| GO:0048255 | mRNA stabilization |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0042476 | odontogenesis |
| GO:0010942 | positive regulation of cell death |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0070602 | regulation of centromeric sister chromatid cohesion |
| GO:0061181 | regulation of chondrocyte development |
| GO:0032423 | regulation of mismatch repair |
| GO:0003139 | secondary heart field specification |
| GO:0001756 | somitogenesis |
| GO:0016055 | Wnt signaling pathway |