| Tag | Content |
|---|---|
| Uniprot ID | P57095; Q335M5; |
| Entrez ID | 58080 |
| Genbank protein ID | AAK70877.1; CAH69531.1; BAA92440.1; |
| Genbank nucleotide ID | NM_131561.1 |
| Ensembl protein ID | ENSDARP00000143690; ENSDARP00000132477; |
| Ensembl nucleotide ID | ENSDARG00000100149 |
| Gene name | Axin-2 |
| Gene symbol | axin2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos (PubMed:30467143). |
| Sequence | MNRTLTDPMV SSFREDDPRP PVPGEEGETT CHHPSKLAMM RPKDPVKTIM ADLRCSTARR 60 DEDGLGEPEG SASPDSPLAR WTKSLHFLLG DQDGAQLFRA YLEREKCVDT LDFWFACNGF 120 RQMDLKDTKT HRVAKAIYKR YIENNSIVAK QLKPATKTFI RDNIKRQQID SAMFDQAQME 180 IQTAMEENAY QMFLTSDIYL EYVRTGCENP SHVNPNGLGG LKLVCGYLPT LNEEEEWSCN 240 DFKAKALATV VGLSAKTLRS PPLRAVEALE KGYRSYRRSD PGNPNRFTSG YSFAPATSAN 300 DSEVSSDALT DDSMSMTDSS VDAIPPYKLG SKKQLQREMQ RNMRMNGQVS LPPFPRTRRP 360 PKEMTPVEPA AFAAQLIARL ERLKREQETM SSLEERLQQI QEEEERDESE MSSSSASHSL 420 PLLPPGTCEE DPQAILDEHL SRVLKTPGCQ SPGLLRHSPR SRSPEQRPLP RGGLSTRSQS 480 SSMNGYVPAK TFISRQSTKH IHHHYIHHHA GPKSKEQIEV EATQRVQCLC HGTSECCTAP 540 YIRSRSLGRD QCASPAEVAL GHSSTLSKRL CKSGEEVNME GLENSLLQLP ADSTDRSQNV 600 WQWILESDRQ TKHKPHSTQN VKKSHSLEPT RTHTWGGGGS SGHLRAHQPA HPFVQDPAMP 660 PLPPPNTLAQ LEEARRRLEE VSKPSKQRHS TSSLQRDKSH PVPVQNGSSA FPMDERKDPK 720 KMSGCHSSLG SETVVTYFFC GEEIPYRRMM KTHSLTLGHF KEQLRKKGNY RYFFKRASDE 780 FECGAVFEEV WDDCTVLPMY EGKILGKVDR MD 812 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AXIN2 | 490903 | E2R9F8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 102180348 | A0A452FEH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 8313 | Q9Y2T1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Axin2 | 12006 | O88566 | E13.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | AXIN2 | 468301 | A0A2I3SZU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | A0A287BFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Axin2 | A0A0G2K4L4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | axin2 | 58080 | P57095 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0009950 | dorsal/ventral axis specification |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0007507 | heart development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification |
| GO:0016055 | Wnt signaling pathway |