Gene: AXIN2

Basic information

Tag Content
Uniprot ID A0A452FEH8
Entrez ID 102180348
Genbank protein ID
Genbank nucleotide ID XM_018063950.1
Ensembl protein ID ENSCHIP00000022676
Ensembl nucleotide ID ENSCHIG00000020538
Gene name Uncharacterized protein
Gene symbol AXIN2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSSAVLVPRL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGPAAKAPP VSPSARRNEG 60
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 120
NLQDAKTSRV AKAIYKRYIE NNSIVSKQLR PATKAYIRDS IKKQQIDSVM FDQAQTEVQA 180
VMEENAYQTF LTSDICLEYV GSGGENPAYL SQGGLGSLRL VCGYLPTLNE EEEWTCADFK 240
CKLPPTVVGL SSKTLRATAS ARAMDTMESG YRSFRRSDPV NPYHVGSGYV FAPAASANDS 300
EISSDALTDD SMSMTDSSVD GVPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 360
EMTPVEPAAF AAELIARLEK LKLELETRHS LEERLQQIQE DEEKEGAELA PGSREAGPAP 420
HPLCLLPSSS YEEDPQTILD DHLSRVLKTP GCQSPGMGRY SPRARSPDHH HRHHLQPHRA 480
LPPPGGPLPP AAVPASCSLL GARGFVSRQA TKHVHHHYIH HHAGPRTRDE AEAEAAPRAR 540
CPCPVPGGAD YSCCGKCKSH PGVPEPPGAA QLGRGGVPPR RSARGSEPGP TVLAREAGAP 600
GGVGSLQPPG EEGDRAQVVW QWVLESERPG KPKPHSAQST KRAYPTESAR VSPAERAGRH 660
HLWGGGTGHP RAVPRAHPAC TQDSAVPPLT PPNTLAQLEE ACRRLAEVSK PPKQRCCAAG 720
QQKDRSHPGP GMPGAAPFSS PSPALEDHKE PRKLAGMHAL QASELVVTYF FCGEEIPYRR 780
MLKAQSLTLG HFKEQLSKKG NYRYYFKKAS DEFACGAVFE EVWDDEVVLP MYEGRILGKV 840
ERID 844

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologAXIN2490903E2R9F8Canis lupus familiarisPredictionMore>>
1:1 orthologAXIN2102180348A0A452FEH8Capra hircusPredictionMore>>
1:1 orthologAXIN28313Q9Y2T1Homo sapiensPublicationMore>>
1:1 orthologAxin212006O88566E13.5Mus musculusPredictionMore>>
1:1 orthologAXIN2468301A0A2I3SZU8Pan troglodytesPredictionMore>>
1:1 orthologAXIN2A0A287BFQ6Sus scrofaPredictionMore>>
1:1 orthologAxin2A0A0G2K4L4Rattus norvegicusPredictionMore>>
1:1 orthologaxin258080P57095Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005813 centrosome
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0070411 I-SMAD binding
GO:0031625 ubiquitin protein ligase binding
GO:0030282 bone mineralization
GO:0008283 cell population proliferation
GO:0034613 cellular protein localization
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0001957 intramembranous ossification
GO:0043570 maintenance of DNA repeat elements
GO:0048255 mRNA stabilization
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0008285 negative regulation of cell population proliferation
GO:0045668 negative regulation of osteoblast differentiation
GO:0042476 odontogenesis
GO:0010942 positive regulation of cell death
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0061181 regulation of chondrocyte development
GO:0032423 regulation of mismatch repair
GO:0003139 secondary heart field specification
GO:0001756 somitogenesis
GO:0016055 Wnt signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR014936 Axin_b-cat-bd
IPR032101 Axin_TNKS-bd
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

PROSITE

PROSITE ID PROSITE Term
PS50841 DIX
PS50132 RGS

Pfam

Pfam ID Pfam Term
PF16646 AXIN1_TNKS_BD
PF08833 Axin_b-cat_bind
PF00778 DIX
PF00615 RGS