| Tag | Content |
|---|---|
| Uniprot ID | A0A452FEH8 |
| Entrez ID | 102180348 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018063950.1 |
| Ensembl protein ID | ENSCHIP00000022676 |
| Ensembl nucleotide ID | ENSCHIG00000020538 |
| Gene name | Uncharacterized protein |
| Gene symbol | AXIN2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSAVLVPRL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGPAAKAPP VSPSARRNEG 60 GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 120 NLQDAKTSRV AKAIYKRYIE NNSIVSKQLR PATKAYIRDS IKKQQIDSVM FDQAQTEVQA 180 VMEENAYQTF LTSDICLEYV GSGGENPAYL SQGGLGSLRL VCGYLPTLNE EEEWTCADFK 240 CKLPPTVVGL SSKTLRATAS ARAMDTMESG YRSFRRSDPV NPYHVGSGYV FAPAASANDS 300 EISSDALTDD SMSMTDSSVD GVPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 360 EMTPVEPAAF AAELIARLEK LKLELETRHS LEERLQQIQE DEEKEGAELA PGSREAGPAP 420 HPLCLLPSSS YEEDPQTILD DHLSRVLKTP GCQSPGMGRY SPRARSPDHH HRHHLQPHRA 480 LPPPGGPLPP AAVPASCSLL GARGFVSRQA TKHVHHHYIH HHAGPRTRDE AEAEAAPRAR 540 CPCPVPGGAD YSCCGKCKSH PGVPEPPGAA QLGRGGVPPR RSARGSEPGP TVLAREAGAP 600 GGVGSLQPPG EEGDRAQVVW QWVLESERPG KPKPHSAQST KRAYPTESAR VSPAERAGRH 660 HLWGGGTGHP RAVPRAHPAC TQDSAVPPLT PPNTLAQLEE ACRRLAEVSK PPKQRCCAAG 720 QQKDRSHPGP GMPGAAPFSS PSPALEDHKE PRKLAGMHAL QASELVVTYF FCGEEIPYRR 780 MLKAQSLTLG HFKEQLSKKG NYRYYFKKAS DEFACGAVFE EVWDDEVVLP MYEGRILGKV 840 ERID 844 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AXIN2 | 490903 | E2R9F8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 102180348 | A0A452FEH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 8313 | Q9Y2T1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Axin2 | 12006 | O88566 | E13.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | AXIN2 | 468301 | A0A2I3SZU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | A0A287BFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Axin2 | A0A0G2K4L4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | axin2 | 58080 | P57095 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005813 | centrosome |
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0070411 | I-SMAD binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0030282 | bone mineralization |
| GO:0008283 | cell population proliferation |
| GO:0034613 | cellular protein localization |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO:0001957 | intramembranous ossification |
| GO:0043570 | maintenance of DNA repeat elements |
| GO:0048255 | mRNA stabilization |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0042476 | odontogenesis |
| GO:0010942 | positive regulation of cell death |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0070602 | regulation of centromeric sister chromatid cohesion |
| GO:0061181 | regulation of chondrocyte development |
| GO:0032423 | regulation of mismatch repair |
| GO:0003139 | secondary heart field specification |
| GO:0001756 | somitogenesis |
| GO:0016055 | Wnt signaling pathway |