| Tag | Content |
|---|---|
| Uniprot ID | E2R9F8 |
| Entrez ID | 490903 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_548025.5; XM_005624273.2; XM_005624272.2; |
| Ensembl protein ID | ENSCAFP00000016564 |
| Ensembl nucleotide ID | ENSCAFG00000011236 |
| Gene name | Axin 2 |
| Gene symbol | AXIN2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSAVLVTRL PDPSSSFHED APRPPVPGEE GETPPCQPGL GKGQVTKPMP VSSNARRNED 60 GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE RDKCVDTLDF WFACNGFRQM 120 NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK PATKTYIRDG IKKQQIDSIM FDQAQTEIQS 180 VMEENAYQMF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV VCGYLPTLNE EEEWACADFK 240 CKLSPTVVGL SSKTLRATAN VRSTETVENG YRSFKRSDPV NPYHVGSGYV FAPATSANDS 300 EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 360 EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEASELA LSSREGGPTP 420 HPLSLLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HHHHQQYHPL 480 LPPGGKLPPM AASQAGCPLL GAKGFVTKQT TKHVHHHYIH HHALPKTKEE IEAEAAQRVR 540 CFCPGGTEYY CYSKCRSHPK ALEPVQAEQF SSSRGSTLPK RNGKSVELGL ALPAREGGAP 600 GGAGVLQLPG EEGDRSQDVW QWMLESERQS KPKPPSAQST KKAYPLESAR ASPAERAGRH 660 HLLGGSNGHP RAAPRAHPFT QDPAMPPLTP PNTLAQLEEA CRRLAEVSKP PKQRCCAASQ 720 QRDRNHSATG QTGATPFSNP GLASEDHKEP KKLAGVHALQ ASELVVTYFF CGEEIPYRRM 780 LKAQSLTLGH FKEQLSKKGN YRYYFKKASD EFACGAVFEE IWDDEAVLPM YEGRILGKVE 840 RID 843 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AXIN2 | 490903 | E2R9F8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 102180348 | A0A452FEH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 8313 | Q9Y2T1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Axin2 | 12006 | O88566 | E13.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | AXIN2 | 468301 | A0A2I3SZU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | A0A287BFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Axin2 | A0A0G2K4L4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | axin2 | 58080 | P57095 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005813 | centrosome |
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0070411 | I-SMAD binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0030282 | bone mineralization |
| GO:0008283 | cell population proliferation |
| GO:0034613 | cellular protein localization |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO:0001957 | intramembranous ossification |
| GO:0043570 | maintenance of DNA repeat elements |
| GO:0048255 | mRNA stabilization |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0042476 | odontogenesis |
| GO:0010942 | positive regulation of cell death |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0070602 | regulation of centromeric sister chromatid cohesion |
| GO:0061181 | regulation of chondrocyte development |
| GO:0032423 | regulation of mismatch repair |
| GO:0003139 | secondary heart field specification |
| GO:0001756 | somitogenesis |
| GO:0016055 | Wnt signaling pathway |