| Tag | Content |
|---|---|
| Uniprot ID | O88566; Q6PFZ9; Q9QXJ6; |
| Entrez ID | 12006 |
| Genbank protein ID | AAC26047.1; EDL34346.1; AAH57338.1; AAF22800.1; |
| Genbank nucleotide ID | XM_006532057.3; XM_006532059.3; XM_006532058.1; NM_015732.4; XM_006532060.1; |
| Ensembl protein ID | ENSMUSP00000051331 |
| Ensembl nucleotide ID | ENSMUSG00000000142 |
| Gene name | Axin-2 |
| Gene symbol | Axin2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E13.5 |
| Data sources | Homology search |
| Reference | |
| Functional description | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Sequence | MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP VSSNARRNED 60 GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 120 NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK PATKTYIRDG IKKQQIGSVM FDQAQTEIQA 180 VMEENAYQVF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK 240 CKLSPTVVGL SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 300 ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 360 EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEGSEQA LSSRDGAPVQ 420 HPLALLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH 480 TLLPTGGKLP PVAACPLLGG KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL 540 CPGGTDYYCY SKCKSHPKAP EPLPGEQFCG SRGGTLPKRN AKGTEPGLAL SARDGGMSSA 600 AGAPQLPGEE GDRSQDVWQW MLESERQSKS KPHSAQSIRK SYPLESACAA PGERVSRHHL 660 LGASGHSRSV ARAHPFTQDP AMPPLTPPNT LAQLEEACRR LAEVSKPQKQ RCCVASQQRD 720 RNHSAAGQAG ASPFANPSLA PEDHKEPKKL ASVHALQASE LVVTYFFCGE EIPYRRMLKA 780 QSLTLGHFKE QLSKKGNYRY YFKKASDEFA CGAVFEEIWD DETVLPMYEG RILGKVERID 840 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AXIN2 | 490903 | E2R9F8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 102180348 | A0A452FEH8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | 8313 | Q9Y2T1 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Axin2 | 12006 | O88566 | E13.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | AXIN2 | 468301 | A0A2I3SZU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | AXIN2 | A0A287BFQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Axin2 | A0A0G2K4L4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | axin2 | 58080 | P57095 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0008013 | beta-catenin binding | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0031625 | ubiquitin protein ligase binding | ISO |
| GO:0031625 | ubiquitin protein ligase binding | IPI |
| GO:0070411 | I-SMAD binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001756 | somitogenesis | IDA |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0001957 | intramembranous ossification | IMP |
| GO:0003139 | secondary heart field specification | IGI |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis | IMP |
| GO:0008219 | cell death | ISO |
| GO:0008283 | cell population proliferation | IMP |
| GO:0008285 | negative regulation of cell population proliferation | ISO |
| GO:0008285 | negative regulation of cell population proliferation | IMP |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition | ISO |
| GO:0010942 | positive regulation of cell death | ISO |
| GO:0016055 | Wnt signaling pathway | IEA |
| GO:0030111 | regulation of Wnt signaling pathway | IDA |
| GO:0030282 | bone mineralization | IMP |
| GO:0032423 | regulation of mismatch repair | ISO |
| GO:0034613 | cellular protein localization | ISO |
| GO:0042476 | odontogenesis | ISO |
| GO:0043570 | maintenance of DNA repeat elements | ISO |
| GO:0045668 | negative regulation of osteoblast differentiation | IMP |
| GO:0045860 | positive regulation of protein kinase activity | ISO |
| GO:0048255 | mRNA stabilization | ISO |
| GO:0061181 | regulation of chondrocyte development | IMP |
| GO:0070602 | regulation of centromeric sister chromatid cohesion | ISO |
| GO:0070602 | regulation of centromeric sister chromatid cohesion | IMP |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | ISO |
| GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005813 | centrosome | ISO |
| GO:0005813 | centrosome | IDA |
| GO:0032991 | protein-containing complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-4641257 | Degradation of AXIN | IEA |
| R-MMU-5688426 | Deubiquitination | IEA |
| R-MMU-5689880 | Ub-specific processing proteases | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |