| Tag | Content |
|---|---|
| Uniprot ID | A0A0R4IFK9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000132105 |
| Ensembl nucleotide ID | ENSDARG00000102607 |
| Gene name | Alpha-MPP |
| Gene symbol | pmpca |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. |
| Sequence | MAAHMSRLRG WSRAQRYGIA VCRQYSSGSS YPNVSLSTPL PGIPKPVFAS VDGHEKYETK 60 ITTLENGLKI ASQNKFGQFC TVGILVNSGS RHEAKYPSGI AHFLEKLSFS STAQFGSKDE 120 ILLTLEKHGG ICDCQTSRDT TMYAVSAEVK GLDTVVHLLS DAVLQPRLLD EEIEMARMAV 180 RFELEDLNMR PDPEPLLTEM IHAAAYRGNT VGLPRFSPAD NVEKIDKKLL HKYLQSYYCP 240 ERMVLAGVGI EHEQLVQCAR KYLLNVQPVW GESKPANVDR SVAQYTGGIV KMVKDMSDVS 300 LGPTPIPELT HIMIGLESCS FLEEDFIPFA VLNMMMGGGG SFSAGGPGKG MFTRLYLNVL 360 NRHHWMYNAT SYHHSYEDSG LLCIHASADP RQVREMVEII TREFIQMTGT AGEMELERAK 420 TQLKSMLMMN LESRPVIFED VGRQVLATGK RKLPHELCEL ISTVTASDIK RVTMKMLRSK 480 PAVAALGDLT ELPSYEDIQA ALSSKDGRLP RIYRLFR 517 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PMPCA | 767847 | Q0P5M8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 480677 | F1PF09 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 102171796 | A0A452EEL9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 23203 | Q10713 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pmpca | 66865 | Q9DC61 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PMPCA | H2QY64 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PMPCA | A0A5G2Q8L1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pmpca | 296588 | Q68FX8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pmpca | A0A0R4IFK9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005743 | mitochondrial inner membrane |
| GO:0005759 | mitochondrial matrix |
| GO:0005739 | mitochondrion |
| GO:0046872 | metal ion binding |
| GO:0006627 | protein processing involved in protein targeting to mitochondrion |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00143 | INSULINASE |