| Tag | Content |
|---|---|
| Uniprot ID | Q0P5M8 |
| Entrez ID | 767847 |
| Genbank protein ID | AAI19850.1 |
| Genbank nucleotide ID | NM_001076964.1 |
| Ensembl protein ID | ENSBTAP00000001782 |
| Ensembl nucleotide ID | ENSBTAG00000001353 |
| Gene name | Mitochondrial-processing peptidase subunit alpha |
| Gene symbol | PMPCA |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. |
| Sequence | MAAMVLAATR LLRGSGSWGR SRPRFGDPAY RRFSSGGAYP NIPLSSPLPG VPKPVFATVD 60 GQEKFETKVT TLDNGLRVAS QNKFGQFCTV GILINSGSRY EAKYLSGIAH FLEKLAFSST 120 ERFDSKDEIL LTLEKHGGIC DCQTSRDTTM YAVSADSKGL DTVVGLLADV VLHPRLTDEE 180 IEMARMAVQF ELEDLNMRPD PEPLLTEMVH EAAYRENTVG LHRFCPAENV GKMDRDVLHA 240 YLRNYYTPDR MVLAGVGVEH AQLVECARKY LLGTCPAWGT GAAVHVDRSV AQYTGGIVKL 300 ERDMSNVSLG PTPFPELTHI MIGLESCSFL EGDFIPFAVL NMMMGGGGSF SAGGPGKGMF 360 TRLYLNVLNR HHWMYNATSY HHSYEDTGLL CIHASADPRQ VREMVEIVTR EFVLMAGTVD 420 VVELERAKTQ LTSMLMMNLE ARPVIFEDVG RQVLATRSRK LPHELCALIR DVKPEDIKRV 480 ASKMLRGKPA VAALGDLSEL PAYEHVQAAL ASRDGRLPRV YRLFR 525 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PMPCA | 767847 | Q0P5M8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 480677 | F1PF09 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 102171796 | A0A452EEL9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 23203 | Q10713 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pmpca | 66865 | Q9DC61 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PMPCA | H2QY64 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PMPCA | A0A5G2Q8L1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pmpca | 296588 | Q68FX8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pmpca | A0A0R4IFK9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005743 | mitochondrial inner membrane |
| GO:0017087 | mitochondrial processing peptidase complex |
| GO:0005739 | mitochondrion |
| GO:0046872 | metal ion binding |
| GO:0004222 | metalloendopeptidase activity |
| GO:0006627 | protein processing involved in protein targeting to mitochondrion |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00143 | INSULINASE |