| Tag | Content |
|---|---|
| Uniprot ID | Q9DC61; Q3TF19; |
| Entrez ID | 66865 |
| Genbank protein ID | BAB23363.1; BAE41094.1; BAE27682.1; AAH10810.1; BAE41079.1; |
| Genbank nucleotide ID | NM_173180.3 |
| Ensembl protein ID | ENSMUSP00000075762 |
| Ensembl nucleotide ID | ENSMUSG00000026926 |
| Gene name | Mitochondrial-processing peptidase subunit alpha |
| Gene symbol | Pmpca |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19668215 |
| Functional description | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. |
| Sequence | MATAVWAAAR LLRGSAVLCA RPRFGSPAHR RFSSGATYPN IPLSSPLPGV PKPIFATVDG 60 QEKFETKVTT LDNGLRVASQ NKFGQFCTVG ILINSGSRYE AKYLSGIAHF LEKLAFSSTA 120 RFDSKDEILL TLEKHGGICD CQTSRDTTMY AVSADSKGLD TVVDLLADVV LHPRLTDEEI 180 EMTRMAVQFE LEDLNMRPDP EPLLTEMIHE AAFRENTVGL HRFCPVENIA KIDREVLHSY 240 LKNYYTPDRM VLAGVGVEHE HLVECARKYL VGAEPAWGAP GTVDVDRSVA QYTGGIIKVE 300 RDMSNVSLGP TPIPELTHIM VGLESCSFLE DDFIPFAVLN MMMGGGGSFS AGGPGKGMFS 360 RLYLNVLNRH HWMYNATSYH HSYEDTGLLC IHASADPRQV REMVEIITKE FILMGRTVDL 420 VELERAKTQL MSMLMMNLES RPVIFEDVGR QVLATHSRKL PHELCTLIRN VKPEDIKRVA 480 SKMLRGKPAV AALGDLTDLP TYEHIQAALS SRNGHLPRSY RLFR 524 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PMPCA | 767847 | Q0P5M8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 480677 | F1PF09 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 102171796 | A0A452EEL9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PMPCA | 23203 | Q10713 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pmpca | 66865 | Q9DC61 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PMPCA | H2QY64 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PMPCA | A0A5G2Q8L1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pmpca | 296588 | Q68FX8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pmpca | A0A0R4IFK9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004175 | endopeptidase activity | ISO |
| GO:0004222 | metalloendopeptidase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
| GO:0004175 | endopeptidase activity | IBA |
| GO:0008237 | metallopeptidase activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006508 | proteolysis | ISO |
| GO:0006627 | protein processing involved in protein targeting to mitochondrion | ISS |
| GO:0006627 | protein processing involved in protein targeting to mitochondrion | ISO |
| GO:0006627 | protein processing involved in protein targeting to mitochondrion | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005739 | mitochondrion | ISO |
| GO:0005739 | mitochondrion | HDA |
| GO:0005739 | mitochondrion | IBA |
| GO:0005743 | mitochondrial inner membrane | ISS |
| GO:0005743 | mitochondrial inner membrane | ISO |
| GO:0005743 | mitochondrial inner membrane | IBA |
| GO:0017087 | mitochondrial processing peptidase complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-382551 | Transport of small molecules | IEA |
| R-MMU-8949215 | Mitochondrial calcium ion transport | IEA |
| R-MMU-8949664 | Processing of SMDT1 | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00143 | INSULINASE |