Gene: PMPCA

Basic information

Tag Content
Uniprot ID F1PF09
Entrez ID 480677
Genbank protein ID
Genbank nucleotide ID XM_537796.5
Ensembl protein ID ENSCAFP00000029108
Ensembl nucleotide ID ENSCAFG00000019672
Gene name Peptidase, mitochondrial processing alpha subunit
Gene symbol PMPCA
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAAMVVAAAR VLLRGSGSWR CSRLRSGAPS RRQFSGGGAY PHVPLSSPLP GVPEPVFATV 60
DGQEKFETKV TTLDNGLRVA SQNKFGQFCT VGILINSGSR YEAKYLSGIA HFLEKLAFSS 120
TDRFESKDEI LLTLEKHGGI CDCQTSRDTT MYAVSADSKG LDTVVGLLAD VVLHPRLTDK 180
EIEMTRMAVQ FELEDLNMRP DPEPLLTEMI HEAAYRENTV GLHRFCPTEN IAKIDREVLH 240
SYLRNYYTPD RMVLAGVGVE HEHLVECARK YLLGTQPAWG CEKAVDVDRS VAQYTGGVVK 300
LERDMSNVSL GPAPFPELTH IMIGLESCSF LEEDFIPFAV LNMMMGGGGS FSAGGPGKGM 360
FTRLYLNVLN RHHWMYNATS YHHSYEDTGL LCVHASADPR QVREMVEILT KEFILMAGTV 420
DVVELERAKT QLMSMLMMNL ESRPVIFEDV GRQVLATRSR KLPHELCALI RSVKPEDIRR 480
VASQMLCRKP AVAALGDLSH LPAYEHIQAA LSSRDGRLPR TYRLFR 526

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPMPCA767847Q0P5M8Bos taurusPredictionMore>>
1:1 orthologPMPCA480677F1PF09Canis lupus familiarisPredictionMore>>
1:1 orthologPMPCA102171796A0A452EEL9Capra hircusPredictionMore>>
1:1 orthologPMPCA23203Q10713Homo sapiensPredictionMore>>
1:1 orthologPmpca66865Q9DC61CPOMus musculusPublicationMore>>
1:1 orthologPMPCAH2QY64Pan troglodytesPredictionMore>>
1:1 orthologPMPCAA0A5G2Q8L1Sus scrofaPredictionMore>>
1:1 orthologPmpca296588Q68FX8Rattus norvegicusPredictionMore>>
1:1 orthologpmpcaA0A0R4IFK9Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005743 mitochondrial inner membrane
GO:0017087 mitochondrial processing peptidase complex
GO:0005739 mitochondrion
GO:0046872 metal ion binding
GO:0004222 metalloendopeptidase activity
GO:0006627 protein processing involved in protein targeting to mitochondrion

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
IPR037715 PMPCA

PROSITE

PROSITE ID PROSITE Term
PS00143 INSULINASE

Pfam

Pfam ID Pfam Term
PF00675 Peptidase_M16
PF05193 Peptidase_M16_C