Gene: NUAK1

Basic information

Tag Content
Uniprot ID A0A287AGV4
Entrez ID 100523669
Genbank protein ID
Genbank nucleotide ID XM_003126093.5
Ensembl protein ID ENSSSCP00000043266
Ensembl nucleotide ID ENSSSCG00000032861
Gene name NUAK family kinase 1
Gene symbol NUAK1
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEGAAAAAAG DGPDLGLGTP GSPPEAGAGA TAAPAAAAPE PRKPHGVKRH HHKHNLKHRY 60
ELQETLGKGT YGKVKRATER FSGRVVAIKS IRKDKIKDEQ DMVHIRREIE IMSSLSHPHI 120
ISIYEVFENK DKIVIIMEYA SKGELYDYIS ERRRLSERET RHFFRQIVSA VHYCHKNGVV 180
HRDLKLENIL LDDNCNIKIA DFGLSNLYQK DKFLQTFCGS PLYASPEIVN GRPYRGPEVD 240
SWALGVLLYT LVYGTMPFDG FDHKNLIRQI SSGEYREPTQ PSDARGLIRW MLMVNPDRRA 300
TIEDIANHWW VNWGYKSSVC DCDALHSSES PLLARIIDWH HRSTGLQVEA DAKVKGLAKP 360
GAPEVVLERQ RSLKKSKKEN DFAQSGQDAV PESPSKLSSK RPKGILKKRS NSEHRSHSTG 420
FIEGVVSPAL PPTFKMEQDL CRTAVPLPSS PEAEVPGKLS PKQSATMPKK GILKKTQQRE 480
SGYYSSPERS ESSELLDTND GLGGPVPSPS PPDAARAPPH SLSCRRKGIL KHSSKYSAGT 540
MDPALASPEM PTLESLLEPG VPAEGISRSY SRPSSVISDD SVLSSDSFDL LDLQENRPAR 600
QRIRSCVSAE NFLQIQDFER LQNRPRPQYL KRYRNRLGDS SFSLLTDMDD VTQVYKKALE 660
ICNKLN 666

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNUAK1519892E1B9B6Bos taurusPredictionMore>>
1:1 orthologNUAK1481296J9P812Canis lupus familiarisPredictionMore>>
1:1 orthologNUAK1102190764A0A452G5R0Capra hircusPredictionMore>>
1:1 orthologNUAK19891O60285Homo sapiensPredictionMore>>
1:1 orthologNuak177976Q641K5CPOMus musculusPublicationMore>>
1:1 orthologNUAK1742637H2Q6S1Pan troglodytesPredictionMore>>
1:1 orthologNUAK1100523669A0A287AGV4Sus scrofaPredictionMore>>
1:1 orthologNuak1299694D3ZQN8Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0001650 fibrillar center
GO:0015630 microtubule cytoskeleton
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0005524 ATP binding
GO:0002039 p53 binding
GO:0004674 protein serine/threonine kinase activity
GO:0035556 intracellular signal transduction
GO:0006468 protein phosphorylation
GO:0030155 regulation of cell adhesion
GO:2000772 regulation of cellular senescence
GO:0035507 regulation of myosin-light-chain-phosphatase activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase