| Tag | Content |
|---|---|
| Uniprot ID | D3ZQN8 |
| Entrez ID | 299694 |
| Genbank protein ID | EDM17090.1 |
| Genbank nucleotide ID | NM_001106774.1 |
| Ensembl protein ID | ENSRNOP00000010636 |
| Ensembl nucleotide ID | ENSRNOG00000008061 |
| Gene name | NUAK family kinase 1 |
| Gene symbol | Nuak1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEGAAVSAAG DGPAVETGLP GSPREVVAGA TAAPVEPRKP HGVKRHHHKH NLKHRYELQE 60 TLGKGTYGKV KRATERFSGR VVAIKSIRKD KIKDELDMVH IRREIEIMSS LNHPHIISIY 120 EVFENKDKIV IIMEYASKGE LYDYISERRR LSERETRHFF RQIVSAVHYC HKNGVVHRDL 180 KLENILLDDN CNIKIADFGL SNLYQKDKFL QTFCGSPLYA SPEIVNGRPY RGPEVDSWAL 240 GVLLYTLIYG TMPFDGFDHK NLIRQISSGE YREPTQPSDA RGLIRWMLMV NPDRRATIED 300 IANHWWVNWG YKSSVCDCDA LPDSESPLLA RIIDWHHRST GLQAEADAKM KAKPGASEVV 360 LERQRSLKKS KKENDFPQSG QDSLPESPSK LSSKRPKGIL KKRSNSEHRS HSTGFIEGIV 420 GPALPSPFKM EQDLCRTAIP LPGSPEAQGS SGKLSLKQSA TMPKKGILKK TQQRESGYYS 480 SPERSESSEL LDSNNVIISS GLSSPPPDPA RGTSHSLSCR RKGILKHSSR YSDGATDPAL 540 TGPEIPTLES LSPPGVPSDG ISRSYSRPSS IISDDSVLSS DSFDLLDLQE NRPARQRIRS 600 CVSAENFLQL QDFETPHNRP RPQYLKRYRN RLADSSFSLL ADMDDVTQVY KKALEICSKL 660 N 661 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NUAK1 | 519892 | E1B9B6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NUAK1 | 481296 | J9P812 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | NUAK1 | 102190764 | A0A452G5R0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NUAK1 | 9891 | O60285 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nuak1 | 77976 | Q641K5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NUAK1 | 742637 | H2Q6S1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NUAK1 | 100523669 | A0A287AGV4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Nuak1 | 299694 | D3ZQN8 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0001650 | fibrillar center |
| GO:0015630 | microtubule cytoskeleton |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0002039 | p53 binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0035556 | intracellular signal transduction |
| GO:0006468 | protein phosphorylation |
| GO:0030155 | regulation of cell adhesion |
| GO:2000772 | regulation of cellular senescence |
| GO:0035507 | regulation of myosin-light-chain-phosphatase activity |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |