| Tag | Content |
|---|---|
| Uniprot ID | A0A287AJQ6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000044243 |
| Ensembl nucleotide ID | ENSSSCG00000025689 |
| Gene name | Dishevelled segment polarity protein 2 |
| Gene symbol | DVL2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAGSGAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60 DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPAHEPRTDL APPPPPLPPL 120 PPERTSGIGD SRPPSFHPNV SSSRENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRPS 180 GPSRLERHLA GYESSSTLLT SELESTSLGD SDEDDTLSRF SSSTEQSSAS RLLKRHRRRR 240 KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300 KGGAVAADGR IEPGDMLLQV NDVNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 360 AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSIH 420 TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 480 GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 540 GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 600 AGRTGRPEDR APESKSGSGS ESEPSTRGGS LRRGGESGGT GDGGPPPSRG SSGGAPNVRG 660 HPGLHPYGPP PGVALPYNPM MVVMVPPPRP PSPQQCSLQG PLQSETWAPC PQS 713 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DVL2 | A0A452G485 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DVL2 | 1856 | O14641 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Dvl2 | 13543 | Q60838 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | 455236 | H2QC24 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | A0A287AJQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dvl2 | 303251 | D3ZB71 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dvl2 | F1QM97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005109 | frizzled binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0035556 | intracellular signal transduction |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| InterPro ID | InterPro Term |
|---|---|
| IPR000591 | DEP_dom |
| IPR024580 | Dishevelled_C-dom |
| IPR008339 | Dishevelled_fam |
| IPR003351 | Dishevelled_protein_dom |
| IPR001158 | DIX |
| IPR038207 | DIX_dom_sf |
| IPR015506 | Dsh/Dvl-rel |
| IPR008341 | DVL2 |
| IPR001478 | PDZ |
| IPR036034 | PDZ_sf |
| IPR029071 | Ubiquitin-like_domsf |
| IPR036388 | WH-like_DNA-bd_sf |
| IPR036390 | WH_DNA-bd_sf |