Gene: DVL2

Basic information

Tag Content
Uniprot ID A0A287AJQ6
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSSSCP00000044243
Ensembl nucleotide ID ENSSSCG00000025689
Gene name Dishevelled segment polarity protein 2
Gene symbol DVL2
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAGSGAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPAHEPRTDL APPPPPLPPL 120
PPERTSGIGD SRPPSFHPNV SSSRENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRPS 180
GPSRLERHLA GYESSSTLLT SELESTSLGD SDEDDTLSRF SSSTEQSSAS RLLKRHRRRR 240
KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300
KGGAVAADGR IEPGDMLLQV NDVNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 360
AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSIH 420
TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 480
GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 540
GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 600
AGRTGRPEDR APESKSGSGS ESEPSTRGGS LRRGGESGGT GDGGPPPSRG SSGGAPNVRG 660
HPGLHPYGPP PGVALPYNPM MVVMVPPPRP PSPQQCSLQG PLQSETWAPC PQS 713

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologDVL2A0A452G485Capra hircusPredictionMore>>
1:1 orthologDVL21856O14641CL/PHomo sapiensPublicationMore>>
1:1 orthologDvl213543Q60838Mus musculusPredictionMore>>
1:1 orthologDVL2455236H2QC24Pan troglodytesPredictionMore>>
1:1 orthologDVL2A0A287AJQ6Sus scrofaPredictionMore>>
1:1 orthologDvl2303251D3ZB71Rattus norvegicusPredictionMore>>
1:1 orthologdvl2F1QM97Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005109 frizzled binding
GO:0060070 canonical Wnt signaling pathway
GO:0035556 intracellular signal transduction
GO:0090179 planar cell polarity pathway involved in neural tube closure

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008341 DVL2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS50186 DEP
PS50841 DIX
PS50106 PDZ

Pfam

Pfam ID Pfam Term
PF00610 DEP
PF02377 Dishevelled
PF00778 DIX
PF12316 Dsh_C
PF00595 PDZ