| Tag | Content |
|---|---|
| Uniprot ID | F1QM97 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000021237 |
| Ensembl nucleotide ID | ENSDARG00000056184 |
| Gene name | Dishevelled segment polarity protein 2 |
| Gene symbol | dvl2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAETKIIYHI DEEETPYLVK IPIAAEKITL LDFKQVLNKP NYKFFFKSMD QDFGVVKEEI 60 SDDSAKLPCF NGRVVSWLVS SDTPAAEPVA PPVEVPSQPS PPPPPLPPPP AERMAGIGDS 120 RPPSFHPNTT GSLESLDDQT ETESVVSFRR ERPRPRESLE QHGPRMNGQS RLDRHLAGYE 180 SATTVMSSEL DTTSFCDSDD DDTMSRFSSS TEQSTASRLL KRHRRRRKQR PRLERASSFS 240 SVTDSTMSLN IITVTLNMEK YNFLGISIVG QSNERGDGGI YIGSIMKGGA VAADGRIEPG 300 DMLLQVNDIN FENMSNDDAV RVLREIVHKP GPITLTVAKC WDPSPQGYFT LPRNEPIRPI 360 DPAAWVNHSV ALTGAFPSYP SSTITSSSSV TETERFDEFN LSLRSDMASV AKAMASPESG 420 LEVRDRMWLK ITIPNAFLGS DVVEWLYHHI DGFQDRREAR KYASNLLKAG FIRHTVNKIT 480 FSEQCYYIFG DFSNCENYMA NLSLNDNDGS SGASDQDTLA PLPLPGATPW PLLHSFTYQY 540 PHPYSTQPPP YHELSNYSYG PGSAGSQHSE GSHSSGSTRS DGEKRRGPKS VSESTVGGSV 600 RDDKSPGGGG ADSRSGSGSE SDYSVRSTLR RDHGSATPSE HSRSSQRSHH RVPPPHLAPY 660 PPGIPIPYNP MMVMMVPQHP HLALGAPHPQ TPTLPPHPGL PPTGIPGGPP GAPPTRDLGS 720 VPPELTASRQ SFHLAMGNPS EFFVDVM 747 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DVL2 | A0A452G485 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DVL2 | 1856 | O14641 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Dvl2 | 13543 | Q60838 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | 455236 | H2QC24 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | A0A287AJQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dvl2 | 303251 | D3ZB71 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dvl2 | F1QM97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005938 | cell cortex |
| GO:0005829 | cytosol |
| GO:0005819 | spindle |
| GO:0005109 | frizzled binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0021535 | cell migration in hindbrain |
| GO:0060026 | convergent extension |
| GO:0060028 | convergent extension involved in axis elongation |
| GO:0060322 | head development |
| GO:0035556 | intracellular signal transduction |
| GO:0035567 | non-canonical Wnt signaling pathway |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0036342 | post-anal tail morphogenesis |
| InterPro ID | InterPro Term |
|---|---|
| IPR000591 | DEP_dom |
| IPR024580 | Dishevelled_C-dom |
| IPR008339 | Dishevelled_fam |
| IPR003351 | Dishevelled_protein_dom |
| IPR001158 | DIX |
| IPR038207 | DIX_dom_sf |
| IPR015506 | Dsh/Dvl-rel |
| IPR008341 | DVL2 |
| IPR001478 | PDZ |
| IPR036034 | PDZ_sf |
| IPR029071 | Ubiquitin-like_domsf |
| IPR036388 | WH-like_DNA-bd_sf |
| IPR036390 | WH_DNA-bd_sf |