| Tag | Content |
|---|---|
| Uniprot ID | D3ZB71 |
| Entrez ID | 303251 |
| Genbank protein ID | EDM04961.1 |
| Genbank nucleotide ID | NM_001172056.1 |
| Ensembl protein ID | ENSRNOP00000024348 |
| Ensembl nucleotide ID | ENSRNOG00000017915 |
| Gene name | Dishevelled segment polarity protein 2 |
| Gene symbol | Dvl2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAGSSAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60 DQDFGVVKEE ISDDSARLPC FNGRVVSWLV SSESPQPETA PPAHESRTEL VPPPPPLPPL 120 PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RDRPRRRDSS EHGAGGHRPG 180 VPSRLERHLA GYESSSTLMT SELESTSLGD SDEDDSMSRF SSSTEQSSAS RLLKRHRRRR 240 KQRPPRMERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300 KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 360 AYFTLPRNEP IQPIDPAAWV SHSAALTGAF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 420 MDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 480 GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 540 GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYSYGGGS ASSQHSEGSR SSGSTRSDGG 600 AGRTGRPEER APESKSGSGS ESELSSRGGS LRRGGEPGGT GDGGPPPSRG SAGGTPNLRA 660 LPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVSTAVQPPG APPVRDLGSV PPELTASRQS 720 FHMAMGNPSE FFVDVM 736 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DVL2 | A0A452G485 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DVL2 | 1856 | O14641 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Dvl2 | 13543 | Q60838 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | 455236 | H2QC24 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | A0A287AJQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dvl2 | 303251 | D3ZB71 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dvl2 | F1QM97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016235 | aggresome |
| GO:0045177 | apical part of cell |
| GO:0030136 | clathrin-coated vesicle |
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005829 | cytosol |
| GO:0016328 | lateral plasma membrane |
| GO:0016604 | nuclear body |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0005109 | frizzled binding |
| GO:0042802 | identical protein binding |
| GO:0019904 | protein domain specific binding |
| GO:0019901 | protein kinase binding |
| GO:0043621 | protein self-association |
| GO:0030674 | protein-macromolecule adaptor activity |
| GO:0048365 | Rac GTPase binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0044340 | canonical Wnt signaling pathway involved in regulation of cell proliferation |
| GO:0034613 | cellular protein localization |
| GO:0090103 | cochlea morphogenesis |
| GO:0022007 | convergent extension involved in neural plate elongation |
| GO:0060029 | convergent extension involved in organogenesis |
| GO:0007507 | heart development |
| GO:0003007 | heart morphogenesis |
| GO:0035556 | intracellular signal transduction |
| GO:0001843 | neural tube closure |
| GO:0035567 | non-canonical Wnt signaling pathway |
| GO:0003151 | outflow tract morphogenesis |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0043547 | positive regulation of GTPase activity |
| GO:0043507 | positive regulation of JUN kinase activity |
| GO:0150012 | positive regulation of neuron projection arborization |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0061098 | positive regulation of protein tyrosine kinase activity |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0007379 | segment specification |
| GO:0035282 | segmentation |
| GO:0006366 | transcription by RNA polymerase II |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR000591 | DEP_dom |
| IPR024580 | Dishevelled_C-dom |
| IPR008339 | Dishevelled_fam |
| IPR003351 | Dishevelled_protein_dom |
| IPR001158 | DIX |
| IPR038207 | DIX_dom_sf |
| IPR015506 | Dsh/Dvl-rel |
| IPR008341 | DVL2 |
| IPR001478 | PDZ |
| IPR036034 | PDZ_sf |
| IPR029071 | Ubiquitin-like_domsf |
| IPR036388 | WH-like_DNA-bd_sf |
| IPR036390 | WH_DNA-bd_sf |