| Tag | Content |
|---|---|
| Uniprot ID | H2QC24; A0A2J8KPW4; |
| Entrez ID | 455236 |
| Genbank protein ID | JAA06366.1; JAA24615.1; JAA19677.1; |
| Genbank nucleotide ID | XM_009431731.2 |
| Ensembl protein ID | ENSPTRP00000014781 |
| Ensembl nucleotide ID | ENSPTRG00000008665 |
| Gene name | Dishevelled segment polarity protein 2 |
| Gene symbol | DVL2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60 DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL 120 PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG 180 GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR 240 KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300 KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 360 AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 420 TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 480 GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 540 GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 600 AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA 660 HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS 720 FHMAMGNPSE FFVDVM 736 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DVL2 | A0A452G485 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DVL2 | 1856 | O14641 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Dvl2 | 13543 | Q60838 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | 455236 | H2QC24 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | A0A287AJQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dvl2 | 303251 | D3ZB71 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dvl2 | F1QM97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016235 | aggresome |
| GO:0045177 | apical part of cell |
| GO:0030136 | clathrin-coated vesicle |
| GO:0005829 | cytosol |
| GO:0016328 | lateral plasma membrane |
| GO:0016604 | nuclear body |
| GO:0005109 | frizzled binding |
| GO:0042802 | identical protein binding |
| GO:0019904 | protein domain specific binding |
| GO:0019901 | protein kinase binding |
| GO:0043621 | protein self-association |
| GO:0030674 | protein-macromolecule adaptor activity |
| GO:0048365 | Rac GTPase binding |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0044340 | canonical Wnt signaling pathway involved in regulation of cell proliferation |
| GO:0034613 | cellular protein localization |
| GO:0090103 | cochlea morphogenesis |
| GO:0022007 | convergent extension involved in neural plate elongation |
| GO:0035556 | intracellular signal transduction |
| GO:0003151 | outflow tract morphogenesis |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0043547 | positive regulation of GTPase activity |
| GO:0043507 | positive regulation of JUN kinase activity |
| GO:0061098 | positive regulation of protein tyrosine kinase activity |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0007379 | segment specification |
| GO:0006366 | transcription by RNA polymerase II |
| InterPro ID | InterPro Term |
|---|---|
| IPR000591 | DEP_dom |
| IPR024580 | Dishevelled_C-dom |
| IPR008339 | Dishevelled_fam |
| IPR003351 | Dishevelled_protein_dom |
| IPR001158 | DIX |
| IPR038207 | DIX_dom_sf |
| IPR015506 | Dsh/Dvl-rel |
| IPR008341 | DVL2 |
| IPR001478 | PDZ |
| IPR036034 | PDZ_sf |
| IPR029071 | Ubiquitin-like_domsf |
| IPR036388 | WH-like_DNA-bd_sf |
| IPR036390 | WH_DNA-bd_sf |