| Tag | Content |
|---|---|
| Uniprot ID | Q60838; Q7TN14; |
| Entrez ID | 13543 |
| Genbank protein ID | EDL12520.1; AAC52827.1; BAE40307.1; AAH53050.1; BAE35461.1; BAE27460.1; |
| Genbank nucleotide ID | NM_007888.3 |
| Ensembl protein ID | ENSMUSP00000019362; ENSMUSP00000099635; ENSMUSP00000140073; |
| Ensembl nucleotide ID | ENSMUSG00000020888 |
| Gene name | Segment polarity protein dishevelled homolog DVL-2 |
| Gene symbol | Dvl2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Sequence | MAGSSAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60 DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDTPQPEVA PPAHESRTEL VPPPPPLPPL 120 PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RDRPRRRDSS EHGAGGHRPG 180 GPSRLERHLA GYESSSTLMT SELESTSLGD SDEDDTMSRF SSSTEQSSAS RLLKRHRRRR 240 KQRPPRMERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300 KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 360 AYFTLPRNEP IQPIDPAAWV SHSAALTGAF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 420 MDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 480 GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 540 GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 600 AGRTGRPEER APESKSGSGS ESELSSRGGS LRRGGEPGGT GDGGPPPSRG STGAPPNLRA 660 LPGLHPYGAP SGMALPYNPM MVVMMPPPPP PVSTAVQPPG APPVRDLGSV PPELTASRQS 720 FHMAMGNPSE FFVDVM 736 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DVL2 | A0A452G485 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DVL2 | 1856 | O14641 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Dvl2 | 13543 | Q60838 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | 455236 | H2QC24 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DVL2 | A0A287AJQ6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dvl2 | 303251 | D3ZB71 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dvl2 | F1QM97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005109 | frizzled binding | ISO |
| GO:0005109 | frizzled binding | IPI |
| GO:0005109 | frizzled binding | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0019901 | protein kinase binding | IPI |
| GO:0019904 | protein domain specific binding | IPI |
| GO:0030674 | protein binding, bridging | IDA |
| GO:0042802 | identical protein binding | ISO |
| GO:0042802 | identical protein binding | IPI |
| GO:0043621 | protein self-association | IDA |
| GO:0048365 | Rac GTPase binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001843 | neural tube closure | IMP |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0003007 | heart morphogenesis | IGI |
| GO:0003151 | outflow tract morphogenesis | IMP |
| GO:0006366 | transcription by RNA polymerase II | ISO |
| GO:0007379 | segment specification | IMP |
| GO:0007507 | heart development | IMP |
| GO:0022007 | convergent extension involved in neural plate elongation | IGI |
| GO:0022007 | convergent extension involved in neural plate elongation | IMP |
| GO:0034613 | cellular protein localization | IDA |
| GO:0035282 | segmentation | IGI |
| GO:0035556 | intracellular signal transduction | IEA |
| GO:0035567 | non-canonical Wnt signaling pathway | ISO |
| GO:0043507 | positive regulation of JUN kinase activity | ISO |
| GO:0043507 | positive regulation of JUN kinase activity | IDA |
| GO:0043547 | positive regulation of GTPase activity | IDA |
| GO:0044340 | canonical Wnt signaling pathway involved in regulation of cell proliferation | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | ISO |
| GO:0060029 | convergent extension involved in organogenesis | IGI |
| GO:0060070 | canonical Wnt signaling pathway | ISO |
| GO:0060070 | canonical Wnt signaling pathway | IGI |
| GO:0060070 | canonical Wnt signaling pathway | IMP |
| GO:0060070 | canonical Wnt signaling pathway | IDA |
| GO:0060070 | canonical Wnt signaling pathway | IBA |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | ISO |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IGI |
| GO:0061098 | positive regulation of protein tyrosine kinase activity | IGI |
| GO:0090103 | cochlea morphogenesis | IGI |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure | IGI |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure | IMP |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure | IBA |
| GO:0150012 | positive regulation of neuron projection arborization | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IMP |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | IDA |
| GO:0005829 | cytosol | IBA |
| GO:0005856 | cytoskeleton | NAS |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | IGI |
| GO:0005938 | cell cortex | ISO |
| GO:0016235 | aggresome | ISO |
| GO:0016328 | lateral plasma membrane | IDA |
| GO:0016604 | nuclear body | ISO |
| GO:0030136 | clathrin-coated vesicle | IDA |
| GO:0031410 | cytoplasmic vesicle | ISO |
| GO:0045177 | apical part of cell | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-201688 | WNT mediated activation of DVL | IEA |
| R-MMU-2028269 | Signaling by Hippo | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-4608870 | Asymmetric localization of PCP proteins | IEA |
| R-MMU-4641258 | Degradation of DVL | IEA |
| R-MMU-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | IEA |
| R-MMU-5099900 | WNT5A-dependent internalization of FZD4 | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-5663220 | RHO GTPases Activate Formins | IEA |
| R-MMU-8856825 | Cargo recognition for clathrin-mediated endocytosis | IEA |
| R-MMU-8856828 | Clathrin-mediated endocytosis | IEA |
| InterPro ID | InterPro Term |
|---|---|
| IPR000591 | DEP_dom |
| IPR024580 | Dishevelled_C-dom |
| IPR008339 | Dishevelled_fam |
| IPR003351 | Dishevelled_protein_dom |
| IPR001158 | DIX |
| IPR038207 | DIX_dom_sf |
| IPR015506 | Dsh/Dvl-rel |
| IPR008341 | DVL2 |
| IPR001478 | PDZ |
| IPR036034 | PDZ_sf |
| IPR029071 | Ubiquitin-like_domsf |
| IPR036388 | WH-like_DNA-bd_sf |
| IPR036390 | WH_DNA-bd_sf |