Gene: REN

Basic information

Tag Content
Uniprot ID A0A287APG1
Entrez ID
Genbank protein ID HDC57944.1
Genbank nucleotide ID
Ensembl protein ID ENSSSCP00000045910
Ensembl nucleotide ID ENSSSCG00000031235
Gene name Renin
Gene symbol REN
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDRWSSMPCW GLLLVLWGSC TFGLPADTGA FSRIFLKKMP SVRESLKERG VDMARLGAEW 60
SQFSKRLSFG NRTSPVVLTN YLDTQYYGEI GIGTPPQTFK VIFDTGSANL WVPSTKCSPL 120
YTACEIHSLY DSSESSSYVE NGTEFTIHYG SGKVKGFLSQ DLVTVGGFTV TQTFGEVTEL 180
PLIPFMLAKF DGVLGMGFPA QAVGGVTPVF DHILSQKVLK EDVFSVYYSR NSKNSQLLGG 240
EIVLGGSDPQ YYQDSFHYVS ISKTGSWQIK MKGVSVRSAT LLCEEGCMVV VDTGASYISG 300
PTSSLRLLME TLGAKELSTD EYVVNCNQVP TLPDISFHLG GRAYTLTSAD YVLQDPYNND 360
DLCTLALHGL DVPPPTGPVW VLGASFIRKF YTEFDRRNNR IGFALAR 407

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologREN403838Q6DYE7Canis lupus familiarisPredictionMore>>
1:1 orthologRENA0A452ERZ4Capra hircusPredictionMore>>
1:1 orthologREN5972P00797Homo sapiensPublicationMore>>
1:1 orthologRen119701P06281Mus musculusPredictionMore>>
1:1 orthologREN469651H2R877Pan troglodytesPredictionMore>>
1:1 orthologRENA0A287APG1Sus scrofaPredictionMore>>
1:1 orthologRen124715P08424Rattus norvegicusPredictionMore>>
1:1 orthologrenQ6XQJ0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0045177 apical part of cell
GO:0005615 extracellular space
GO:0004190 aspartic-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0002003 angiotensin maturation
GO:0048469 cell maturation
GO:0042756 drinking behavior
GO:0009755 hormone-mediated signaling pathway
GO:0008584 male gonad development
GO:0001823 mesonephros development
GO:0006508 proteolysis
GO:0043408 regulation of MAPK cascade
GO:0002018 renin-angiotensin regulation of aldosterone production

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0064 Aspartyl protease
KW-1015 Disulfide bond
KW-0378 Hydrolase
KW-0645 Protease
KW-1185 Reference proteome
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR034135 Renin-like_dom

PROSITE

PROSITE ID PROSITE Term
PS00141 ASP_PROTEASE
PS51767 PEPTIDASE_A1

Pfam

Pfam ID Pfam Term
PF07966 A1_Propeptide
PF00026 Asp