CleftGeneDB-Search

Gene: REN

Basic information

Tag	Content
Uniprot ID	P00797; Q6FI38; Q6T5C2;
Entrez ID	5972
Genbank protein ID	AAA60364.1; AAA60263.1; ABY87560.1; AAA60262.1; AAR03502.1; AAH33474.1; AAH47752.1; AAA60365.1; CAG38737.1; AAA60363.1; AAD03461.1;
Genbank nucleotide ID	NM_000537.3
Ensembl protein ID	ENSP00000272190
Ensembl nucleotide ID	ENSG00000143839
Gene name	Renin
Gene symbol	REN
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	2309700; 8454288;
Functional description	Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Sequence	MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG VDMARLGPEW 60 SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK VVFDTGSSNV WVPSSKCSRL 120 YTACVYHKLF DASDSSSYKH NGTELTLRYS TGTVSGFLSQ DIITVGGITV TQMFGEVTEM 180 PALPFMLAEF DGVVGMGFIE QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG 240 QIVLGGSDPQ HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG 300 STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY VFQESYSSKK 360 LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI GFALAR 406

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1BBS
1BIL
1BIM
1HRN
1RNE
2BKS
2BKT
2FS4
2G1N
2G1O
2G1R
2G1S
2G1Y
2G20
2G21
2G22
2G24
2G26
2G27
2I4Q
2IKO
2IKU
2IL2
2REN
2V0Z
2V10
2V11
2V12
2V13
2V16
2X0B
3D91
3G6Z
3G70
3G72
3GW5
3K1W
3KM4
3O9L
3OAD
3OAG
3OOT
3OQF
3OQK
3OWN
3Q3T
3Q4B
3Q5H
3SFC
3VCM
3VSW
3VSX
3VUC
3VYD
3VYE
3VYF
4AMT
4GJ5
4GJ6
4GJ7
4GJ8
4GJ9
4GJA
4GJB
4GJC
4GJD
4PYV
4Q1N
4RYC
4RYG
4RZ1
4S1G
4XX3
4XX4
5KOQ
5KOS
5KOT
5SXN
5SY2
5SY3
5SZ9
5T4S
5TMG
5TMK
5V8V
5VPM
5VRP
6I3F
1BBS
2G27
3GW5
3K1W
3SFC
3VCM

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Species	Evidence	Details
1:1 ortholog	REN	403838	Q6DYE7	Canis lupus familiaris	Prediction	More>>
1:1 ortholog	REN		A0A452ERZ4	Capra hircus	Prediction	More>>
1:1 ortholog	REN	5972	P00797	Homo sapiens	Publication	More>>
1:1 ortholog	Ren1	19701	P06281	Mus musculus	Prediction	More>>
1:1 ortholog	REN	469651	H2R877	Pan troglodytes	Prediction	More>>
1:1 ortholog	REN		A0A287APG1	Sus scrofa	Prediction	More>>
1:1 ortholog	Ren1	24715	P08424	Rattus norvegicus	Prediction	More>>
1:1 ortholog	ren		Q6XQJ0	Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs769289753	p.Gly3Glu	missense variant	-	NC_000001.11:g.204166286C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Trp4GlyPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.204166284A>-	NCI-TCGA
rs775844948	p.Arg5Gly	missense variant	-	NC_000001.11:g.204166281T>C	ExAC,gnomAD
rs753328645	p.Arg6Lys	missense variant	-	NC_000001.11:g.204166277C>T	ExAC,TOPMed,gnomAD
rs1392033638	p.Arg6Ser	missense variant	-	NC_000001.11:g.204166276C>A	gnomAD
rs746180535	p.Met7Leu	missense variant	-	NC_000001.11:g.204166275T>G	ExAC,gnomAD
RCV000375769	p.Pro8Ala	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204166272G>C	ClinVar
rs61746500	p.Pro8Ala	missense variant	-	NC_000001.11:g.204166272G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000318852	p.Pro8Ala	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204166272G>C	ClinVar
rs777899883	p.Arg9Leu	missense variant	-	NC_000001.11:g.204166268C>A	ExAC,TOPMed,gnomAD
rs777899883	p.Arg9His	missense variant	-	NC_000001.11:g.204166268C>T	NCI-TCGA,NCI-TCGA Cosmic
rs115181548	p.Arg9Cys	missense variant	-	NC_000001.11:g.204166269G>A	NCI-TCGA,NCI-TCGA Cosmic
rs115181548	p.Arg9Ser	missense variant	-	NC_000001.11:g.204166269G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs115181548	p.Arg9Cys	missense variant	-	NC_000001.11:g.204166269G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs777899883	p.Arg9His	missense variant	-	NC_000001.11:g.204166268C>T	ExAC,TOPMed,gnomAD
rs1167571128	p.Trp10Ter	stop gained	-	NC_000001.11:g.204166265C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Trp10Ter	stop gained	-	NC_000001.11:g.204166264C>T	NCI-TCGA
COSM4542533	p.Gly11Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204166263C>T	NCI-TCGA Cosmic
rs1456036182	p.Leu12Met	missense variant	-	NC_000001.11:g.204166260G>T	gnomAD
NCI-TCGA novel	p.Leu15Pro	missense variant	-	NC_000001.11:g.204166250A>G	NCI-TCGA
RCV000505648	p.Leu16His	missense variant	Hyperuricemic nephropathy, familial juvenile, 2 (HNFJ2)	NC_000001.11:g.204166247A>T	ClinVar
RCV000014006	p.Leu16Arg	missense variant	Hyperuricemic nephropathy, familial juvenile, 2 (HNFJ2)	NC_000001.11:g.204166247A>C	ClinVar
rs121917743	p.Leu16Arg	missense variant	Hyperuricemic nephropathy, familial juvenile, 2 (hnfj2)	NC_000001.11:g.204166247A>C	-
rs121917743	p.Leu16Arg	missense variant	Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)	NC_000001.11:g.204166247A>C	UniProt,dbSNP
VAR_063770	p.Leu16Arg	missense variant	Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)	NC_000001.11:g.204166247A>C	UniProt
rs121917743	p.Leu16His	missense variant	Hyperuricemic nephropathy, familial juvenile, 2 (hnfj2)	NC_000001.11:g.204166247A>T	-
rs1420333399	p.Thr21Ile	missense variant	-	NC_000001.11:g.204166232G>A	TOPMed,gnomAD
rs1420333399	p.Thr21Asn	missense variant	-	NC_000001.11:g.204166232G>T	TOPMed,gnomAD
rs866965047	p.Leu24Phe	missense variant	-	NC_000001.11:g.204166224G>A	gnomAD
rs761487063	p.Pro25Leu	missense variant	-	NC_000001.11:g.204166220G>A	ExAC,TOPMed,gnomAD
rs763754855	p.Thr28Asn	missense variant	-	NC_000001.11:g.204166211G>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr29Ala	missense variant	-	NC_000001.11:g.204166209T>C	NCI-TCGA
rs368813719	p.Thr29Asn	missense variant	-	NC_000001.11:g.204166208G>T	ESP,ExAC,gnomAD
rs1203318715	p.Phe31Leu	missense variant	-	NC_000001.11:g.204166203A>G	gnomAD
rs543353436	p.Lys32Thr	missense variant	-	NC_000001.11:g.204166199T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs11571098	p.Arg33Trp	missense variant	-	NC_000001.11:g.204166197G>A	ESP,ExAC,TOPMed,gnomAD
rs375880823	p.Arg33Gln	missense variant	-	NC_000001.11:g.204166196C>T	ESP,ExAC,TOPMed,gnomAD
RCV000681790	p.Met39Lys	missense variant	-	NC_000001.11:g.204162146A>T	ClinVar
rs1436346379	p.Pro40Ser	missense variant	-	NC_000001.11:g.204162144G>A	TOPMed
rs1211945323	p.Ser41Ter	stop gained	-	NC_000001.11:g.204162140G>C	TOPMed
rs397514690	p.Arg43Ter	stop gained	-	NC_000001.11:g.204162135G>A	NCI-TCGA
rs397514690	p.Arg43Ter	stop gained	-	NC_000001.11:g.204162135G>A	TOPMed,gnomAD
RCV000043472	p.Arg43Ter	nonsense	Renal dysplasia (RTD)	NC_000001.11:g.204162135G>A	ClinVar
COSM2214138	p.Arg43Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204162134C>T	NCI-TCGA Cosmic
COSM4833961	p.Arg43Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204162134C>G	NCI-TCGA Cosmic
rs748270341	p.Glu48Asp	missense variant	-	NC_000001.11:g.204162118T>A	ExAC,gnomAD
RCV000014003	p.Arg49Ter	nonsense	Renal dysplasia (RTD)	NC_000001.11:g.204162117G>A	ClinVar
rs121917741	p.Arg49Ter	stop gained	-	NC_000001.11:g.204162117G>A	NCI-TCGA
rs768773475	p.Arg49Gln	missense variant	-	NC_000001.11:g.204162116C>T	ExAC,gnomAD
rs121917741	p.Arg49Ter	stop gained	-	NC_000001.11:g.204162117G>A	ExAC,TOPMed,gnomAD
rs745849711	p.Asp52His	missense variant	-	NC_000001.11:g.204162108C>G	ExAC,gnomAD
rs1194228285	p.Met53Thr	missense variant	-	NC_000001.11:g.204162104A>G	gnomAD
rs367565954	p.Arg55Ser	missense variant	-	NC_000001.11:g.204162097C>A	ESP,ExAC,gnomAD
rs756019722	p.Arg55Thr	missense variant	-	NC_000001.11:g.204162098C>G	TOPMed
rs367565954	p.Arg55Ser	missense variant	-	NC_000001.11:g.204162097C>G	ESP,ExAC,gnomAD
rs1353997293	p.Gly57Asp	missense variant	-	NC_000001.11:g.204162092C>T	gnomAD
rs777584055	p.Gly57Ser	missense variant	-	NC_000001.11:g.204162093C>T	ExAC,gnomAD
rs752391620	p.Glu59Lys	missense variant	-	NC_000001.11:g.204162087C>T	ExAC,gnomAD
rs764714841	p.Trp60Arg	missense variant	-	NC_000001.11:g.204162084A>T	ExAC,TOPMed,gnomAD
rs764714841	p.Trp60Gly	missense variant	-	NC_000001.11:g.204162084A>C	ExAC,TOPMed,gnomAD
rs1045353423	p.Met64Val	missense variant	-	NC_000001.11:g.204162072T>C	TOPMed
rs1045353423	p.Met64Leu	missense variant	-	NC_000001.11:g.204162072T>A	TOPMed
rs754493054	p.Arg66Met	missense variant	-	NC_000001.11:g.204162065C>A	ExAC,gnomAD
rs920051455	p.Thr68Ile	missense variant	-	NC_000001.11:g.204162059G>A	gnomAD
rs773505649	p.Gly70Asp	missense variant	-	NC_000001.11:g.204162053C>T	ExAC,TOPMed,gnomAD
rs767727275	p.Asn71Asp	missense variant	-	NC_000001.11:g.204162051T>C	ExAC,TOPMed,gnomAD
rs557010306	p.Thr72Asn	missense variant	-	NC_000001.11:g.204162047G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs768667467	p.Thr73Asn	missense variant	-	NC_000001.11:g.204162044G>T	ExAC,gnomAD
rs536696119	p.Ser74Phe	missense variant	-	NC_000001.11:g.204162041G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs536696119	p.Ser74Tyr	missense variant	-	NC_000001.11:g.204162041G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs777778258	p.Val76Met	missense variant	-	NC_000001.11:g.204162036C>T	ExAC,gnomAD
rs574100052	p.Ile77Ser	missense variant	-	NC_000001.11:g.204162032A>C	1000Genomes,ExAC,TOPMed,gnomAD
rs574100052	p.Ile77Thr	missense variant	-	NC_000001.11:g.204162032A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs141467355	p.Ile77Met	missense variant	-	NC_000001.11:g.204162031G>C	ESP,TOPMed,gnomAD
rs1459578412	p.Leu78Ile	missense variant	-	NC_000001.11:g.204162030G>T	NCI-TCGA
rs1459578412	p.Leu78Ile	missense variant	-	NC_000001.11:g.204162030G>T	gnomAD
rs778600672	p.Thr79Ser	missense variant	-	NC_000001.11:g.204162026G>C	ExAC,TOPMed,gnomAD
rs144219651	p.Met82Lys	missense variant	-	NC_000001.11:g.204162017A>T	ESP,ExAC,TOPMed,gnomAD
rs370001090	p.Thr84Asn	missense variant	-	NC_000001.11:g.204161414G>T	1000Genomes,ESP,ExAC,gnomAD
rs1301244321	p.Gln85His	missense variant	-	NC_000001.11:g.204161410C>G	gnomAD
rs763302196	p.Tyr86Cys	missense variant	-	NC_000001.11:g.204161408T>C	ExAC,gnomAD
rs752956824	p.Tyr87His	missense variant	-	NC_000001.11:g.204161406A>G	ExAC,gnomAD
RCV000305365	p.Glu89Asp	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204161398C>A	ClinVar
RCV000266537	p.Glu89Asp	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204161398C>A	ClinVar
rs886045835	p.Glu89Asp	missense variant	-	NC_000001.11:g.204161398C>A	TOPMed,gnomAD
rs201438857	p.Glu89Lys	missense variant	-	NC_000001.11:g.204161400C>T	1000Genomes,ExAC,gnomAD
rs772001785	p.Ile90Thr	missense variant	-	NC_000001.11:g.204161396A>G	ExAC,gnomAD
rs1435136049	p.Gly91Asp	missense variant	-	NC_000001.11:g.204161393C>T	gnomAD
rs1475981961	p.Gly93Ser	missense variant	-	NC_000001.11:g.204161388C>T	TOPMed,gnomAD
COSM1338056	p.Pro95HisPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.204161381G>-	NCI-TCGA Cosmic
rs1363702826	p.Thr98Ala	missense variant	-	NC_000001.11:g.204161373T>C	gnomAD
rs748996008	p.Val101Ile	missense variant	-	NC_000001.11:g.204161364C>T	ExAC,gnomAD
rs1280455872	p.Val102Ile	missense variant	-	NC_000001.11:g.204161361C>T	NCI-TCGA Cosmic
rs1280455872	p.Val102Ile	missense variant	-	NC_000001.11:g.204161361C>T	gnomAD
rs1211712060	p.Phe103Ser	missense variant	-	NC_000001.11:g.204161357A>G	gnomAD
rs868694193	p.Asp104Asn	missense variant	-	NC_000001.11:g.204161355C>T	gnomAD
rs1294490587	p.Gly106Cys	missense variant	-	NC_000001.11:g.204161349C>A	gnomAD
rs1409715151	p.Ser107Leu	missense variant	-	NC_000001.11:g.204161345G>A	NCI-TCGA Cosmic
RCV000723164	p.Ser107Leu	missense variant	-	NC_000001.11:g.204161345G>A	ClinVar
rs1409715151	p.Ser107Leu	missense variant	-	NC_000001.11:g.204161345G>A	gnomAD
rs556759055	p.Ser108Ala	missense variant	-	NC_000001.11:g.204161343A>C	1000Genomes,ExAC,gnomAD
rs1221956054	p.Val112Ala	missense variant	-	NC_000001.11:g.204161330A>G	TOPMed
rs1474773230	p.Pro113Ser	missense variant	-	NC_000001.11:g.204161328G>A	gnomAD
rs376156157	p.Arg119His	missense variant	-	NC_000001.11:g.204161309C>T	NCI-TCGA,NCI-TCGA Cosmic
rs151265393	p.Arg119Cys	missense variant	-	NC_000001.11:g.204161310G>A	ESP,ExAC,gnomAD
rs376156157	p.Arg119His	missense variant	-	NC_000001.11:g.204161309C>T	ESP,ExAC,TOPMed,gnomAD
rs1352971146	p.Leu120Pro	missense variant	-	NC_000001.11:g.204161306A>G	gnomAD
rs1410855329	p.Tyr121Cys	missense variant	-	NC_000001.11:g.204161303T>C	gnomAD
rs1170054174	p.Tyr121His	missense variant	-	NC_000001.11:g.204161304A>G	gnomAD
rs778261055	p.Thr122Ala	missense variant	-	NC_000001.11:g.204161301T>C	ExAC,gnomAD
rs1186374117	p.Ala123Thr	missense variant	-	NC_000001.11:g.204161298C>T	gnomAD
rs1440602112	p.Val125Ala	missense variant	-	NC_000001.11:g.204160678A>G	gnomAD
rs779295984	p.His127Arg	missense variant	-	NC_000001.11:g.204160672T>C	ExAC,gnomAD
COSM3481954	p.Leu129His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204160666A>T	NCI-TCGA Cosmic
rs1422936644	p.Asp131Asn	missense variant	-	NC_000001.11:g.204160661C>T	NCI-TCGA Cosmic
rs1422936644	p.Asp131Asn	missense variant	-	NC_000001.11:g.204160661C>T	TOPMed
rs144089286	p.Asp131Glu	missense variant	-	NC_000001.11:g.204160659A>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1159183586	p.Ala132Pro	missense variant	-	NC_000001.11:g.204160658C>G	gnomAD
RCV000408106	p.Ser133Leu	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204160654G>A	ClinVar
RCV000312491	p.Ser133Leu	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204160654G>A	ClinVar
rs756122840	p.Ser133Leu	missense variant	-	NC_000001.11:g.204160654G>A	ExAC,TOPMed,gnomAD
RCV000043473	p.Ser135Tyr	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204160648G>T	ClinVar
rs397514691	p.Ser135Tyr	missense variant	-	NC_000001.11:g.204160648G>T	-
rs762758270	p.Ser136Pro	missense variant	-	NC_000001.11:g.204160646A>G	ExAC,gnomAD
rs764873149	p.Lys139Ter	stop gained	-	NC_000001.11:g.204160637T>A	ExAC,TOPMed,gnomAD
rs776126542	p.Asn141Ser	missense variant	-	NC_000001.11:g.204160630T>C	ExAC,TOPMed,gnomAD
COSM3481952	p.Gly142Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204160627C>T	NCI-TCGA Cosmic
COSM1689657	p.Gly142Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204160628C>T	NCI-TCGA Cosmic
rs1356009355	p.Thr143Arg	missense variant	-	NC_000001.11:g.204160624G>C	gnomAD
COSM1223533	p.Glu144Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.204160622C>A	NCI-TCGA Cosmic
rs770516061	p.Glu144Gln	missense variant	-	NC_000001.11:g.204160622C>G	ExAC,gnomAD
rs746464358	p.Thr146Pro	missense variant	-	NC_000001.11:g.204160616T>G	ExAC,gnomAD
rs371704012	p.Arg148His	missense variant	-	NC_000001.11:g.204160609C>T	NCI-TCGA
rs191049685	p.Arg148Cys	missense variant	-	NC_000001.11:g.204160610G>A	NCI-TCGA,NCI-TCGA Cosmic
rs371704012	p.Arg148His	missense variant	-	NC_000001.11:g.204160609C>T	ESP,ExAC,TOPMed,gnomAD
rs191049685	p.Arg148Cys	missense variant	-	NC_000001.11:g.204160610G>A	1000Genomes,ExAC,TOPMed,gnomAD
COSM1320563	p.Thr151Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204160601T>C	NCI-TCGA Cosmic
rs1229083474	p.Thr151Ile	missense variant	-	NC_000001.11:g.204160600G>A	TOPMed
rs1384871999	p.Val154Ile	missense variant	-	NC_000001.11:g.204160592C>T	gnomAD
NCI-TCGA novel	p.Ser159Ile	missense variant	-	NC_000001.11:g.204160576C>A	NCI-TCGA
rs367805555	p.Gln160Arg	missense variant	-	NC_000001.11:g.204160573T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln160His	missense variant	-	NC_000001.11:g.204160572C>A	NCI-TCGA
rs755377881	p.Asp161Gly	missense variant	-	NC_000001.11:g.204160570T>C	ExAC,gnomAD
rs749571526	p.Ile162Thr	missense variant	-	NC_000001.11:g.204160567A>G	ExAC,gnomAD
rs780104854	p.Thr164Asn	missense variant	-	NC_000001.11:g.204160561G>T	ExAC,TOPMed,gnomAD
rs1276829651	p.Val165Met	missense variant	-	NC_000001.11:g.204159595C>T	TOPMed
rs1326333821	p.Gly167Arg	missense variant	-	NC_000001.11:g.204159589C>T	TOPMed
rs1166573542	p.Thr169Ala	missense variant	-	NC_000001.11:g.204159583T>C	gnomAD
rs776576517	p.Thr169Met	missense variant	-	NC_000001.11:g.204159582G>A	TOPMed,gnomAD
rs139795475	p.Gln172Ter	stop gained	-	NC_000001.11:g.204159574G>A	ESP,TOPMed,gnomAD
rs139795475	p.Gln172Glu	missense variant	-	NC_000001.11:g.204159574G>C	ESP,TOPMed,gnomAD
rs985476332	p.Gly175Val	missense variant	-	NC_000001.11:g.204159564C>A	TOPMed,gnomAD
rs147436851	p.Thr178Met	missense variant	-	NC_000001.11:g.204159555G>A	ESP,ExAC,TOPMed,gnomAD
rs775027150	p.Met180Thr	missense variant	-	NC_000001.11:g.204159549A>G	ExAC,gnomAD
COSM902565	p.Ala182Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204159543G>A	NCI-TCGA Cosmic
rs1457497079	p.Ala182Thr	missense variant	-	NC_000001.11:g.204159544C>T	TOPMed,gnomAD
rs1239082918	p.Pro184Leu	missense variant	-	NC_000001.11:g.204159537G>A	gnomAD
rs775650368	p.Met186Ile	missense variant	-	NC_000001.11:g.204159530C>T	ExAC,TOPMed,gnomAD
rs770190833	p.Ala188Val	missense variant	-	NC_000001.11:g.204159525G>A	ExAC,gnomAD
rs1273084088	p.Ala188Thr	missense variant	-	NC_000001.11:g.204159526C>T	gnomAD
COSM1338054	p.Glu189Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204159521C>A	NCI-TCGA Cosmic
rs771032027	p.Glu189Lys	missense variant	-	NC_000001.11:g.204159523C>T	ExAC,TOPMed,gnomAD
rs1332995811	p.Val193Phe	missense variant	-	NC_000001.11:g.204159511C>A	gnomAD
rs778838428	p.Gly195Asp	missense variant	-	NC_000001.11:g.204159504C>T	ExAC,gnomAD
rs754808366	p.Ile199Thr	missense variant	-	NC_000001.11:g.204159492A>G	ExAC,TOPMed,gnomAD
COSM463791	p.Gln201Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204159486T>A	NCI-TCGA Cosmic
rs138385183	p.Ala202Thr	missense variant	-	NC_000001.11:g.204159484C>T	ESP,ExAC,TOPMed,gnomAD
rs1415983248	p.Ile203Thr	missense variant	-	NC_000001.11:g.204159480A>G	gnomAD
rs1301192173	p.Gly204Cys	missense variant	-	NC_000001.11:g.204159478C>A	TOPMed
rs1156882578	p.Arg205Lys	missense variant	-	NC_000001.11:g.204159474C>T	gnomAD
rs750220974	p.Val206Ile	missense variant	-	NC_000001.11:g.204159472C>T	ExAC,gnomAD
rs1381119367	p.Val206Gly	missense variant	-	NC_000001.11:g.204159471A>C	TOPMed,gnomAD
rs750220974	p.Val206Phe	missense variant	-	NC_000001.11:g.204159472C>A	ExAC,gnomAD
rs1381119367	p.Val206Asp	missense variant	-	NC_000001.11:g.204159471A>T	TOPMed,gnomAD
NCI-TCGA novel	p.Thr207Ala	missense variant	-	NC_000001.11:g.204159469T>C	NCI-TCGA
rs544315427	p.Pro208Ser	missense variant	-	NC_000001.11:g.204159466G>A	NCI-TCGA
rs544315427	p.Pro208Ser	missense variant	-	NC_000001.11:g.204159466G>A	1000Genomes,ExAC,gnomAD
rs764665629	p.Asp211His	missense variant	-	NC_000001.11:g.204159457C>G	ExAC,TOPMed,gnomAD
rs764665629	p.Asp211Asn	missense variant	-	NC_000001.11:g.204159457C>T	ExAC,TOPMed,gnomAD
rs763435711	p.Asn212Ser	missense variant	-	NC_000001.11:g.204159453T>C	ExAC,TOPMed,gnomAD
rs763435711	p.Asn212Ile	missense variant	-	NC_000001.11:g.204159453T>A	ExAC,TOPMed,gnomAD
rs1022198711	p.Ile213Val	missense variant	-	NC_000001.11:g.204159451T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Ile214Ser	missense variant	-	NC_000001.11:g.204159447A>C	NCI-TCGA
rs369647339	p.Ile214Val	missense variant	-	NC_000001.11:g.204159448T>C	ESP,ExAC,TOPMed,gnomAD
rs765560519	p.Ser215Tyr	missense variant	-	NC_000001.11:g.204159444G>T	ExAC,gnomAD
RCV000320838	p.Gly217Arg	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204159439C>T	ClinVar
RCV000286923	p.Gly217Arg	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204159439C>T	ClinVar
rs11571117	p.Gly217Arg	missense variant	-	NC_000001.11:g.204159439C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs11571117	p.Gly217Arg	missense variant	-	NC_000001.11:g.204159439C>T	UniProt,dbSNP
VAR_020376	p.Gly217Arg	missense variant	-	NC_000001.11:g.204159439C>T	UniProt
rs776861775	p.Val218Met	missense variant	-	NC_000001.11:g.204159436C>T	ExAC,gnomAD
rs776861775	p.Val218Leu	missense variant	-	NC_000001.11:g.204159436C>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu221Gln	missense variant	-	NC_000001.11:g.204159427C>G	NCI-TCGA
rs773236366	p.Asp222Glu	missense variant	-	NC_000001.11:g.204159422G>T	ExAC,TOPMed,gnomAD
rs1419147995	p.Val223Ile	missense variant	-	NC_000001.11:g.204159421C>T	NCI-TCGA
rs1419147995	p.Val223Ile	missense variant	-	NC_000001.11:g.204159421C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Ser225Phe	missense variant	-	NC_000001.11:g.204159414G>A	NCI-TCGA
NCI-TCGA novel	p.Ser225Tyr	missense variant	-	NC_000001.11:g.204159414G>T	NCI-TCGA
NCI-TCGA novel	p.Tyr227Ter	stop gained	-	NC_000001.11:g.204159407G>T	NCI-TCGA
rs749227987	p.Asn229Asp	missense variant	-	NC_000001.11:g.204159403T>C	ExAC,gnomAD
rs755890508	p.Asn229Lys	missense variant	-	NC_000001.11:g.204159401G>C	ExAC,TOPMed,gnomAD
rs749227987	p.Asn229Tyr	missense variant	-	NC_000001.11:g.204159403T>A	ExAC,gnomAD
RCV000014004	p.Arg230Lys	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204159399C>T	ClinVar
rs121917742	p.Arg230Lys	missense variant	-	NC_000001.11:g.204159399C>T	ExAC,gnomAD
rs121917742	p.Arg230Lys	missense variant	Renal tubular dysgenesis (RTD)	NC_000001.11:g.204159399C>T	UniProt,dbSNP
VAR_035087	p.Arg230Lys	missense variant	Renal tubular dysgenesis (RTD)	NC_000001.11:g.204159399C>T	UniProt
rs755548418	p.Asp231Val	missense variant	-	NC_000001.11:g.204157367T>A	ExAC,gnomAD
rs759698625	p.Asp231Asn	missense variant	-	NC_000001.11:g.204157368C>T	TOPMed
rs766783107	p.Glu233Ter	stop gained	-	NC_000001.11:g.204157362C>A	ExAC,TOPMed,gnomAD
rs766783107	p.Glu233Lys	missense variant	-	NC_000001.11:g.204157362C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser235Tyr	missense variant	-	NC_000001.11:g.204156791G>T	NCI-TCGA
COSM3481943	p.Ser235Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204156791G>A	NCI-TCGA Cosmic
rs140468858	p.Gln236Pro	missense variant	-	NC_000001.11:g.204156788T>G	ESP,ExAC,gnomAD
rs751716365	p.Gln236His	missense variant	-	NC_000001.11:g.204156787T>A	ExAC,TOPMed,gnomAD
rs916130088	p.Gln236Ter	stop gained	-	NC_000001.11:g.204156789G>A	TOPMed,gnomAD
rs916130088	p.Gln236Lys	missense variant	-	NC_000001.11:g.204156789G>T	TOPMed,gnomAD
rs140771210	p.Ser237Leu	missense variant	-	NC_000001.11:g.204156785G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs140771210	p.Ser237Ter	stop gained	-	NC_000001.11:g.204156785G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1308738937	p.Gly239Ala	missense variant	-	NC_000001.11:g.204156779C>G	gnomAD
rs776733175	p.Gly240Arg	missense variant	-	NC_000001.11:g.204156777C>T	ExAC,TOPMed,gnomAD
rs1027055859	p.Val243Ala	missense variant	-	NC_000001.11:g.204156767A>G	TOPMed,gnomAD
rs1386629048	p.Leu244Pro	missense variant	-	NC_000001.11:g.204156764A>G	gnomAD
NCI-TCGA novel	p.Gly245Glu	missense variant	-	NC_000001.11:g.204156761C>T	NCI-TCGA
rs1295851016	p.Ser247Arg	missense variant	-	NC_000001.11:g.204156754G>T	TOPMed,gnomAD
RCV000366015	p.Asp248Glu	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204156751G>T	ClinVar
rs1417265415	p.Asp248Asn	missense variant	-	NC_000001.11:g.204156753C>T	gnomAD
RCV000269070	p.Asp248Glu	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204156751G>T	ClinVar
rs747881047	p.Asp248Glu	missense variant	-	NC_000001.11:g.204156751G>T	ExAC,TOPMed,gnomAD
rs747881047	p.Asp248Glu	missense variant	-	NC_000001.11:g.204156751G>C	ExAC,TOPMed,gnomAD
rs1438634698	p.Gln250Pro	missense variant	-	NC_000001.11:g.204156746T>G	TOPMed
NCI-TCGA novel	p.Gln250His	missense variant	-	NC_000001.11:g.204156745C>G	NCI-TCGA
rs778501632	p.Tyr252His	missense variant	-	NC_000001.11:g.204156741A>G	ExAC,gnomAD
rs267598319	p.Glu253Lys	missense variant	-	NC_000001.11:g.204156738C>T	1000Genomes,ExAC,TOPMed,gnomAD
COSM3481942	p.Gly254Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204156734C>T	NCI-TCGA Cosmic
rs780556396	p.Phe256Leu	missense variant	-	NC_000001.11:g.204156727G>T	ExAC,gnomAD
rs756580059	p.His257Arg	missense variant	-	NC_000001.11:g.204156725T>C	ExAC,gnomAD
rs750891717	p.His257Gln	missense variant	-	NC_000001.11:g.204156724G>C	ExAC,gnomAD
rs781664088	p.Tyr258Ser	missense variant	-	NC_000001.11:g.204156722T>G	ExAC,gnomAD
rs781664088	p.Tyr258Phe	missense variant	-	NC_000001.11:g.204156722T>A	ExAC,gnomAD
NCI-TCGA novel	p.Ile259Val	missense variant	-	NC_000001.11:g.204156720T>C	NCI-TCGA
rs1476114991	p.Leu261Phe	missense variant	-	NC_000001.11:g.204156714G>A	TOPMed
NCI-TCGA novel	p.Leu261Pro	missense variant	-	NC_000001.11:g.204156713A>G	NCI-TCGA
rs757540389	p.Ile262Thr	missense variant	-	NC_000001.11:g.204156710A>G	ExAC
rs751871530	p.Lys263Arg	missense variant	-	NC_000001.11:g.204156707T>C	ExAC,gnomAD
rs1217546699	p.Gly265Ser	missense variant	-	NC_000001.11:g.204156702C>T	gnomAD
NCI-TCGA novel	p.Trp267Ter	stop gained	-	NC_000001.11:g.204156695C>T	NCI-TCGA
rs1356116794	p.Gln268Lys	missense variant	-	NC_000001.11:g.204156693G>T	gnomAD
rs1188646679	p.Gln268His	missense variant	-	NC_000001.11:g.204156691C>G	TOPMed
rs1254527179	p.Ile269Met	missense variant	-	NC_000001.11:g.204156688A>C	gnomAD
rs758564400	p.Met271Thr	missense variant	-	NC_000001.11:g.204156683A>G	ExAC,gnomAD
RCV000274832	p.Gly273Arg	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204156678C>G	ClinVar
RCV000327573	p.Gly273Arg	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204156678C>G	ClinVar
rs752756662	p.Gly273Arg	missense variant	-	NC_000001.11:g.204156678C>G	ExAC,TOPMed,gnomAD
rs752756662	p.Gly273Arg	missense variant	-	NC_000001.11:g.204156678C>T	ExAC,TOPMed,gnomAD
rs1474446793	p.Gly273Ala	missense variant	-	NC_000001.11:g.204156677C>G	gnomAD
rs745330782	p.Val274Leu	missense variant	-	NC_000001.11:g.204156318C>A	ExAC,TOPMed,gnomAD
rs745330782	p.Val274Met	missense variant	-	NC_000001.11:g.204156318C>T	ExAC,TOPMed,gnomAD
COSM3803553	p.Ser278Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.204156305G>T	NCI-TCGA Cosmic
rs1221041856	p.Ser279Thr	missense variant	-	NC_000001.11:g.204156303A>T	gnomAD
rs1263363751	p.Thr280Ile	missense variant	-	NC_000001.11:g.204156299G>A	TOPMed
rs778337508	p.Leu281Phe	missense variant	-	NC_000001.11:g.204156295C>A	ExAC,gnomAD
rs758810616	p.Leu282Phe	missense variant	-	NC_000001.11:g.204156294G>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu284Lys	missense variant	-	NC_000001.11:g.204156288C>T	NCI-TCGA
rs755102880	p.Gly286Ser	missense variant	-	NC_000001.11:g.204156282C>T	ExAC,TOPMed,gnomAD
COSM1338053	p.Cys287Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204156278C>A	NCI-TCGA Cosmic
rs1400212560	p.Cys287Tyr	missense variant	-	NC_000001.11:g.204156278C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Ala289Thr	missense variant	-	NC_000001.11:g.204156273C>T	NCI-TCGA
rs375015351	p.Thr293Asn	missense variant	-	NC_000001.11:g.204156260G>T	ESP,TOPMed,gnomAD
rs375015351	p.Thr293Ile	missense variant	-	NC_000001.11:g.204156260G>A	ESP,TOPMed,gnomAD
COSM1264002	p.Gly294Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204156258C>T	NCI-TCGA Cosmic
rs1162730926	p.Gly294Asp	missense variant	-	NC_000001.11:g.204156257C>T	gnomAD
rs1387291672	p.Ser301Pro	missense variant	-	NC_000001.11:g.204156237A>G	gnomAD
rs1177030641	p.Ser301Phe	missense variant	-	NC_000001.11:g.204156236G>A	gnomAD
NCI-TCGA novel	p.Thr302ProPheSerTerUnk	frameshift	-	NC_000001.11:g.204156234T>-	NCI-TCGA
rs567503598	p.Thr302Ser	missense variant	-	NC_000001.11:g.204156233G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs567503598	p.Thr302Ile	missense variant	-	NC_000001.11:g.204156233G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1207171046	p.Ser304Phe	missense variant	-	NC_000001.11:g.204156227G>A	gnomAD
rs1450384138	p.Ile305Thr	missense variant	-	NC_000001.11:g.204156224A>G	gnomAD
rs757255143	p.Leu308Ile	missense variant	-	NC_000001.11:g.204156216G>T	ExAC,gnomAD
rs1463746540	p.Met309Thr	missense variant	-	NC_000001.11:g.204156212A>G	TOPMed
rs1306579692	p.Glu310Gly	missense variant	-	NC_000001.11:g.204156209T>C	gnomAD
rs763928168	p.Glu310Gln	missense variant	-	NC_000001.11:g.204156210C>G	ExAC,TOPMed,gnomAD
rs763928168	p.Glu310Lys	missense variant	-	NC_000001.11:g.204156210C>T	ExAC,TOPMed,gnomAD
rs1238980420	p.Glu310Asp	missense variant	-	NC_000001.11:g.204156208C>G	gnomAD
rs1377284248	p.Ala311Val	missense variant	-	NC_000001.11:g.204156206G>A	gnomAD
NCI-TCGA novel	p.Lys315Asn	missense variant	-	NC_000001.11:g.204156193C>A	NCI-TCGA
rs1311159103	p.Lys316Asn	missense variant	-	NC_000001.11:g.204156190C>A	TOPMed,gnomAD
rs1311159103	p.Lys316Asn	missense variant	-	NC_000001.11:g.204156190C>G	TOPMed,gnomAD
rs752426689	p.Leu318Arg	missense variant	-	NC_000001.11:g.204156185A>C	ExAC,gnomAD
rs201922371	p.Phe319Val	missense variant	-	NC_000001.11:g.204156183A>C	TOPMed,gnomAD
rs201922371	p.Phe319Leu	missense variant	-	NC_000001.11:g.204156183A>G	TOPMed,gnomAD
rs776071450	p.Asp320His	missense variant	-	NC_000001.11:g.204156180C>G	ExAC
rs780294356	p.Tyr321Ter	stop gained	-	NC_000001.11:g.204155916A>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr321Ter	stop gained	-	NC_000001.11:g.204155917_204155918insC	NCI-TCGA
rs1320434543	p.Val322Phe	missense variant	-	NC_000001.11:g.204155915C>A	gnomAD
rs745900131	p.Val323Met	missense variant	-	NC_000001.11:g.204155912C>T	ExAC,gnomAD
rs777701286	p.Lys324Arg	missense variant	-	NC_000001.11:g.204155908T>C	ExAC,gnomAD
rs144517174	p.Asn326Lys	missense variant	-	NC_000001.11:g.204155901G>T	ESP,ExAC,TOPMed,gnomAD
rs758396335	p.Asn326Asp	missense variant	-	NC_000001.11:g.204155903T>C	ExAC,gnomAD
rs920158144	p.Glu327Lys	missense variant	-	NC_000001.11:g.204155900C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Gly328Arg	missense variant	-	NC_000001.11:g.204155897C>G	NCI-TCGA
rs1358862852	p.Thr330Ile	missense variant	-	NC_000001.11:g.204155890G>A	gnomAD
rs766077533	p.Asp333Asn	missense variant	-	NC_000001.11:g.204155882C>T	ExAC,gnomAD
rs1170619535	p.Ile334Val	missense variant	-	NC_000001.11:g.204155879T>C	gnomAD
rs536704856	p.His337Tyr	missense variant	-	NC_000001.11:g.204155870G>A	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu338Pro	missense variant	-	NC_000001.11:g.204155866A>G	NCI-TCGA
NCI-TCGA novel	p.Gly339Arg	missense variant	-	NC_000001.11:g.204155864C>T	NCI-TCGA
rs567667202	p.Gly340Val	missense variant	-	NC_000001.11:g.204155860C>A	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Thr344Ala	missense variant	-	NC_000001.11:g.204155849T>C	NCI-TCGA
rs547448871	p.Thr344Met	missense variant	-	NC_000001.11:g.204155848G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs774903315	p.Leu345Phe	missense variant	-	NC_000001.11:g.204155846G>A	ExAC,gnomAD
rs1257300615	p.Ser347Arg	missense variant	-	NC_000001.11:g.204155838G>T	TOPMed,gnomAD
rs1412575410	p.Ala348Thr	missense variant	-	NC_000001.11:g.204155837C>T	TOPMed
rs1199197464	p.Ala348Val	missense variant	-	NC_000001.11:g.204155836G>A	gnomAD
NCI-TCGA novel	p.Asp349Gly	missense variant	-	NC_000001.11:g.204155833T>C	NCI-TCGA
NCI-TCGA novel	p.Tyr350CysPheSerTerUnk	frameshift	-	NC_000001.11:g.204155829_204155830AT>-	NCI-TCGA
rs763339055	p.Phe352Ile	missense variant	-	NC_000001.11:g.204155825A>T	ExAC,TOPMed,gnomAD
rs146220838	p.Glu354Gly	missense variant	-	NC_000001.11:g.204155176T>C	ESP,gnomAD
rs1443433955	p.Tyr356Cys	missense variant	-	NC_000001.11:g.204155170T>C	gnomAD
COSM6124117	p.Ser357Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204155167C>A	NCI-TCGA Cosmic
rs770946516	p.Ser358Ile	missense variant	-	NC_000001.11:g.204155164C>A	ExAC,gnomAD
rs774166976	p.Lys359Ile	missense variant	-	NC_000001.11:g.204155161T>A	ExAC,TOPMed,gnomAD
rs774166976	p.Lys359Arg	missense variant	-	NC_000001.11:g.204155161T>C	ExAC,TOPMed,gnomAD
RCV000296847	p.Lys359Ile	missense variant	Familial juvenile hyperuricemic nephropathy	NC_000001.11:g.204155161T>A	ClinVar
RCV000402439	p.Lys359Ile	missense variant	Renal dysplasia (RTD)	NC_000001.11:g.204155161T>A	ClinVar
NCI-TCGA novel	p.Lys360Met	missense variant	-	NC_000001.11:g.204155158T>A	NCI-TCGA
NCI-TCGA novel	p.Leu361Gln	missense variant	-	NC_000001.11:g.204155155A>T	NCI-TCGA
rs1420701887	p.Thr363Ile	missense variant	-	NC_000001.11:g.204155149G>A	gnomAD
rs768567227	p.Leu364Pro	missense variant	-	NC_000001.11:g.204155146A>G	ExAC,gnomAD
COSM3864174	p.Ala365Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204155143G>A	NCI-TCGA Cosmic
rs1190577198	p.Ile366Phe	missense variant	-	NC_000001.11:g.204155141T>A	gnomAD
rs760985112	p.Ala368Pro	missense variant	-	NC_000001.11:g.204155135C>G	ExAC,TOPMed,gnomAD
rs760985112	p.Ala368Thr	missense variant	-	NC_000001.11:g.204155135C>T	ExAC,TOPMed,gnomAD
rs780953687	p.Pro372Leu	missense variant	-	NC_000001.11:g.204155122G>A	ExAC,TOPMed,gnomAD
rs529829189	p.Pro373Leu	missense variant	-	NC_000001.11:g.204155119G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs368598464	p.Thr375Asn	missense variant	-	NC_000001.11:g.204155113G>T	ESP,ExAC,TOPMed,gnomAD
COSM902561	p.Gly376Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204155111C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Pro377His	missense variant	-	NC_000001.11:g.204155107G>T	NCI-TCGA
rs1342001156	p.Ala380Thr	missense variant	-	NC_000001.11:g.204155099C>T	TOPMed
rs1304427544	p.Ala383Thr	missense variant	-	NC_000001.11:g.204155090C>T	gnomAD
rs753179547	p.Thr384Ala	missense variant	-	NC_000001.11:g.204155087T>C	ExAC
rs765628670	p.Thr384Asn	missense variant	-	NC_000001.11:g.204155086G>T	ExAC,gnomAD
COSM4027218	p.Phe385Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204155084A>T	NCI-TCGA Cosmic
rs1053589414	p.Ile386Val	missense variant	-	NC_000001.11:g.204155081T>C	TOPMed
rs759852484	p.Ile386Thr	missense variant	-	NC_000001.11:g.204155080A>G	ExAC,TOPMed,gnomAD
rs371478505	p.Arg387Gln	missense variant	-	NC_000001.11:g.204155077C>T	ESP,ExAC,TOPMed,gnomAD
RCV000014002	p.Arg387Ter	nonsense	Hyperproreninemia, familial	NC_000001.11:g.204155078G>A	ClinVar
rs121917740	p.Arg387Ter	stop gained	-	NC_000001.11:g.204155078G>A	-
rs376188623	p.Tyr390His	missense variant	-	NC_000001.11:g.204155069A>G	ESP,TOPMed,gnomAD
rs766563216	p.Thr391Pro	missense variant	-	NC_000001.11:g.204155066T>G	ExAC,gnomAD
rs766563216	p.Thr391Ala	missense variant	-	NC_000001.11:g.204155066T>C	ExAC,gnomAD
rs773404995	p.Arg395Trp	missense variant	-	NC_000001.11:g.204155054G>A	ExAC,TOPMed,gnomAD
rs772034401	p.Arg395Leu	missense variant	-	NC_000001.11:g.204155053C>A	ExAC,gnomAD
rs769746703	p.Arg396His	missense variant	-	NC_000001.11:g.204155050C>T	ExAC,TOPMed,gnomAD
rs763037834	p.Arg396Cys	missense variant	-	NC_000001.11:g.204155051G>A	ExAC,gnomAD
rs769746703	p.Arg396Pro	missense variant	-	NC_000001.11:g.204155050C>G	ExAC,TOPMed,gnomAD
rs745611329	p.Asn398Asp	missense variant	-	NC_000001.11:g.204155045T>C	ExAC,gnomAD
rs145852603	p.Arg399His	missense variant	-	NC_000001.11:g.204155041C>T	ESP,ExAC,TOPMed,gnomAD
rs780723377	p.Arg399Cys	missense variant	-	NC_000001.11:g.204155042G>A	ExAC,TOPMed,gnomAD
rs6704321	p.Ala403Thr	missense variant	-	NC_000001.11:g.204155030C>T	TOPMed,gnomAD
rs6704321	p.Ala403Pro	missense variant	-	NC_000001.11:g.204155030C>G	TOPMed,gnomAD
COSM1295733	p.Ala405Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.204155024C>T	NCI-TCGA Cosmic
rs547414447	p.Arg406Cys	missense variant	-	NC_000001.11:g.204155021G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs527291298	p.Arg406His	missense variant	-	NC_000001.11:g.204155020C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs200760827	p.Ter407Leu	stop lost	-	NC_000001.11:g.204155017C>A	1000Genomes,ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000768	Congenital Abnormality	group	BEFREE
C0001206	Acromegaly	disease	BEFREE
C0001339	Acute pancreatitis	disease	BEFREE
C0001403	Addison Disease	disease	BEFREE
C0001430	Adenoma	group	BEFREE
C0001623	Adrenal gland hypofunction	phenotype	BEFREE
C0001624	Adrenal Gland Neoplasms	group	BEFREE
C0001787	Osteoporosis, Age-Related	disease	CTD_human
C0001925	Albuminuria	phenotype	CTD_human
C0001969	Alcoholic Intoxication	disease	PSYGENET
C0001973	Alcoholic Intoxication, Chronic	disease	PSYGENET
C0002152	Alloxan Diabetes	disease	CTD_human
C0002395	Alzheimer's Disease	disease	BEFREE
C0002726	Amyloidosis	disease	BEFREE
C0002871	Anemia	disease	BEFREE;CTD_human;HPO
C0002940	Aneurysm	phenotype	BEFREE
C0002965	Angina, Unstable	disease	BEFREE
C0003460	Anuria	phenotype	HPO
C0003469	Anxiety Disorders	group	BEFREE
C0003504	Aortic Valve Insufficiency	disease	BEFREE
C0003507	Aortic Valve Stenosis	disease	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE
C0004238	Atrial Fibrillation	disease	BEFREE
C0004352	Autistic Disorder	group	BEFREE
C0004775	Bartter Disease	disease	BEFREE;CTD_human
C0005586	Bipolar Disorder	disease	BEFREE;PSYGENET
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0006287	Bronchopulmonary Dysplasia	disease	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007193	Cardiomyopathy, Dilated	group	BEFREE
C0007194	Hypertrophic Cardiomyopathy	disease	BEFREE
C0007222	Cardiovascular Diseases	group	BEFREE
C0007282	Carotid Stenosis	disease	BEFREE
C0007766	Intracranial Aneurysm	disease	BEFREE
C0007785	Cerebral Infarction	disease	BEFREE
C0007820	Cerebrovascular Disorders	group	BEFREE
C0008312	Primary biliary cirrhosis	disease	RGD
C0009319	Colitis	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0010054	Coronary Arteriosclerosis	disease	BEFREE
C0010068	Coronary heart disease	disease	BEFREE
C0010072	Coronary Thrombosis	disease	BEFREE
C0010200	Coughing	phenotype	BEFREE
C0010481	Cushing Syndrome	disease	BEFREE
C0010709	Cyst	phenotype	BEFREE
C0011265	Presenile dementia	disease	BEFREE
C0011570	Mental Depression	disease	BEFREE;PSYGENET
C0011581	Depressive disorder	disease	BEFREE;PSYGENET
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011853	Diabetes Mellitus, Experimental	disease	CTD_human
C0011854	Diabetes Mellitus, Insulin-Dependent	disease	BEFREE
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE
C0011875	Diabetic Angiopathies	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE;LHGDN
C0011884	Diabetic Retinopathy	disease	BEFREE
C0013221	Drug toxicity	group	CTD_human
C0013336	Dwarfism	disease	BEFREE
C0014038	Encephalitis	disease	BEFREE
C0014130	Endocrine System Diseases	group	BEFREE
C0014544	Epilepsy	disease	BEFREE
C0014599	Epithelial hyperplasia	disease	BEFREE
C0015544	Failure to Thrive	disease	BEFREE
C0015934	Fetal Growth Retardation	phenotype	CTD_human
C0016052	Fibromuscular Dysplasia	disease	BEFREE
C0016059	Fibrosis	phenotype	CTD_human
C0017636	Glioblastoma	disease	BEFREE
C0017658	Glomerulonephritis	disease	BEFREE
C0017661	IGA Glomerulonephritis	disease	BEFREE
C0017665	Membranous glomerulonephritis	disease	BEFREE
C0017667	Nodular glomerulosclerosis	disease	BEFREE
C0017668	Focal glomerulosclerosis	disease	BEFREE;HPO
C0018798	Congenital Heart Defects	group	BEFREE
C0018799	Heart Diseases	group	BEFREE;LHGDN
C0018800	Cardiomegaly	phenotype	CTD_human
C0018801	Heart failure	disease	BEFREE;CTD_human
C0018802	Congestive heart failure	disease	BEFREE;CTD_human
C0019061	Hemolytic-Uremic Syndrome	disease	BEFREE
C0019080	Hemorrhage	phenotype	CTD_human
C0020428	Hyperaldosteronism	disease	BEFREE
C0020443	Hypercholesterolemia	disease	BEFREE
C0020445	Hypercholesterolemia, Familial	disease	BEFREE
C0020456	Hyperglycemia	disease	BEFREE;LHGDN
C0020459	Hyperinsulinism	disease	LHGDN
C0020473	Hyperlipidemia	disease	LHGDN
C0020488	Hypernatremia	disease	BEFREE
C0020538	Hypertensive disease	group	BEFREE;CTD_human;LHGDN;RGD
C0020540	Malignant Hypertension	disease	BEFREE;CTD_human
C0020541	Hypertension, Portal	disease	BEFREE
C0020545	Hypertension, Renovascular	disease	BEFREE
C0020595	Hypoaldosteronism	disease	BEFREE
C0020615	Hypoglycemia	disease	BEFREE
C0020625	Hyponatremia	phenotype	BEFREE
C0020649	Hypotension	phenotype	CTD_human;HPO
C0022116	Ischemia	phenotype	CTD_human
C0022548	Keloid	phenotype	BEFREE
C0022658	Kidney Diseases	group	BEFREE;CTD_human
C0022660	Kidney Failure, Acute	disease	BEFREE
C0022661	Kidney Failure, Chronic	disease	BEFREE
C0022679	Cystic kidney	disease	BEFREE
C0022680	Polycystic Kidney Diseases	group	BEFREE
C0022876	Premature Obstetric Labor	phenotype	LHGDN
C0023212	Left-Sided Heart Failure	disease	CTD_human
C0023418	leukemia	disease	BEFREE;LHGDN
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE;LHGDN
C0023473	Myeloid Leukemia, Chronic	disease	BEFREE
C0023787	Lipodystrophy	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE;CTD_human
C0023892	Biliary cirrhosis	disease	RGD
C0023895	Liver diseases	group	BEFREE
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE
C0024141	Lupus Erythematosus, Systemic	disease	BEFREE
C0024299	Lymphoma	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0025048	Meconium Aspiration Syndrome	phenotype	BEFREE
C0025149	Medulloblastoma	disease	BEFREE
C0025500	Mesothelioma	disease	BEFREE
C0025517	Metabolic Diseases	group	BEFREE
C0026267	Mitral Valve Prolapse Syndrome	disease	BEFREE
C0026850	Muscular Dystrophy	disease	BEFREE
C0027051	Myocardial Infarction	disease	BEFREE;CTD_human;LHGDN
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027708	Nephroblastoma	disease	BEFREE
C0027719	Nephrosclerosis	disease	BEFREE
C0027720	Nephrosis	disease	CTD_human
C0027765	nervous system disorder	group	BEFREE
C0028259	Nodule	phenotype	BEFREE
C0028754	Obesity	disease	BEFREE
C0029456	Osteoporosis	disease	BEFREE;CTD_human
C0029458	Osteoporosis, Postmenopausal	disease	BEFREE
C0029459	Osteoporosis, Senile	disease	CTD_human
C0030246	Pustulosis of Palms and Soles	disease	CTD_human
C0030552	Paresis	phenotype	BEFREE
C0030779	Pelger-Huet Anomaly	disease	BEFREE
C0031117	Peripheral Neuropathy	group	BEFREE
C0031269	Peutz-Jeghers Syndrome	disease	BEFREE
C0031511	Pheochromocytoma	disease	BEFREE
C0032019	Pituitary Neoplasms	group	BEFREE
C0032463	Polycythemia Vera	disease	BEFREE
C0032914	Pre-Eclampsia	phenotype	LHGDN
C0032969	Pregnancy in Diabetics	phenotype	BEFREE
C0033626	Protein Deficiency	disease	BEFREE
C0033687	Proteinuria	phenotype	CTD_human
C0033805	Pseudohypoaldosteronism	disease	BEFREE
C0033860	Psoriasis	disease	BEFREE;CTD_human
C0035067	Renal Artery Stenosis	disease	BEFREE
C0035078	Kidney Failure	disease	BEFREE
C0035222	Respiratory Distress Syndrome, Adult	disease	BEFREE
C0035229	Respiratory Insufficiency	phenotype	HPO
C0035309	Retinal Diseases	group	BEFREE
C0036421	Systemic Scleroderma	disease	BEFREE
C0037090	Signs and Symptoms, Respiratory	group	BEFREE
C0038358	Gastric ulcer	disease	BEFREE
C0038433	Streptozotocin Diabetes	disease	CTD_human
C0038454	Cerebrovascular accident	group	BEFREE
C0038587	Substance Withdrawal Syndrome	disease	CTD_human
C0039235	Tachycardia, Ectopic Junctional	disease	BEFREE
C0040028	Thrombocythemia, Essential	disease	BEFREE
C0041408	Turner Syndrome	disease	BEFREE
C0041696	Unipolar Depression	disease	BEFREE;PSYGENET
C0041755	Adverse reaction to drug	group	CTD_human
C0041956	Ureteral obstruction	phenotype	BEFREE
C0042075	Urologic Diseases	group	BEFREE
C0042373	Vascular Diseases	group	BEFREE
C0042514	Tachycardia, Ventricular	disease	LHGDN
C0042580	Vesico-Ureteral Reflux	disease	BEFREE
C0042721	Viral hepatitis	group	BEFREE
C0042769	Virus Diseases	group	BEFREE
C0042870	Vitamin D Deficiency	disease	BEFREE
C0079924	Oligohydramnios	phenotype	HPO
C0085083	Ovarian Hyperstimulation Syndrome	disease	BEFREE
C0085215	Ovarian Failure, Premature	disease	BEFREE
C0085413	Polycystic Kidney, Autosomal Dominant	disease	BEFREE
C0085569	Metabolic acidosis, NAG, acidifying salts	disease	BEFREE
C0085580	Essential Hypertension	disease	BEFREE
C0085679	Hyperchloremia	disease	BEFREE
C0086189	Drug Withdrawal Symptoms	phenotype	CTD_human
C0087169	Withdrawal Symptoms	phenotype	CTD_human
C0149721	Left Ventricular Hypertrophy	disease	BEFREE;CTD_human
C0149871	Deep Vein Thrombosis	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0149931	Migraine Disorders	group	BEFREE
C0149939	Obstructive nephropathy	disease	BEFREE
C0151744	Myocardial Ischemia	disease	BEFREE
C0151786	Muscle Weakness	phenotype	BEFREE
C0152136	Low Tension Glaucoma	disease	BEFREE
C0152424	Common ventricle	disease	BEFREE
C0155616	Secondary hypertension	disease	BEFREE
C0155626	Acute myocardial infarction	disease	BEFREE
C0155668	Old myocardial infarction	phenotype	BEFREE
C0155800	Chronic hypotension	disease	BEFREE
C0162119	Hemoglobin low	phenotype	HPO
C0162770	Right Ventricular Hypertrophy	disease	BEFREE
C0162871	Aortic Aneurysm, Abdominal	disease	BEFREE
C0175697	Van der Woude syndrome	disease	BEFREE
C0178664	Glomerulosclerosis (disorder)	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0202236	Triglycerides measurement	phenotype	GWASDB
C0205944	Sarcoma, Epithelioid	disease	BEFREE
C0206093	Neuroectodermal Tumors	disease	BEFREE
C0206663	Neuroectodermal Tumor, Primitive	disease	BEFREE
C0206667	Adrenal Cortical Adenoma	disease	BEFREE
C0206686	Adrenocortical carcinoma	disease	BEFREE
C0206733	Strawberry nevus of skin	disease	BEFREE
C0220666	ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA	disease	BEFREE
C0220983	Metabolic alkalosis	disease	BEFREE
C0221043	Liddle Syndrome	disease	BEFREE;CTD_human
C0221155	Systolic hypertension	disease	BEFREE
C0233532	Maladaptive behavior associated with physical illness	phenotype	BEFREE
C0233629	Thinking and speaking disturbances	phenotype	BEFREE
C0235031	Neurologic Symptoms	group	BEFREE
C0235222	Diastolic hypertension	disease	BEFREE
C0235394	Wasting	disease	BEFREE
C0235527	Heart Failure, Right-Sided	disease	CTD_human
C0238288	Muscular Dystrophy, Facioscapulohumeral	disease	BEFREE
C0238506	Congenital posterior urethral valves	disease	BEFREE
C0239946	Fibrosis, Liver	disease	BEFREE;CTD_human
C0242129	Thrombotic stroke	disease	BEFREE
C0242231	Coronary Stenosis	disease	BEFREE
C0242528	Azotemia	disease	CTD_human
C0264638	Low-renin essential hypertension	disease	BEFREE
C0264639	High-renin essential hypertension	disease	BEFREE
C0264641	Endocrine hypertension	disease	BEFREE
C0264716	Chronic heart failure	disease	BEFREE
C0264733	Ventricular dilatation (disorder)	disease	BEFREE
C0265293	Frontometaphyseal dysplasia	disease	BEFREE
C0265783	Congenital hypoplasia of lung	disease	BEFREE;HPO
C0266295	Congenital hypoplasia of kidney	disease	HPO
C0266313	Allanson Pantzar McLeod syndrome	disease	BEFREE;CLINVAR;CTD_human;HPO;ORPHANET;UNIPROT
C0266619	Potter's facies	disease	HPO
C0266929	Chronic Periodontitis	disease	BEFREE
C0268016	Chronic hypokalemia	disease	BEFREE
C0268436	Pseudohypoaldosteronism, Type I	disease	BEFREE
C0268450	Gitelman Syndrome	disease	BEFREE
C0268731	Renal glomerular disease	group	BEFREE
C0268790	Renal vascular disorder	group	BEFREE
C0271650	Impaired glucose tolerance	phenotype	BEFREE
C0333186	Restenosis	phenotype	BEFREE
C0333559	Infarction, Lacunar	disease	BEFREE
C0338656	Impaired cognition	disease	BEFREE
C0338908	Mixed anxiety and depressive disorder	disease	BEFREE
C0339467	Proliferative retinopathy	disease	BEFREE
C0340100	High altitude pulmonary edema	disease	BEFREE
C0340288	Stable angina	disease	BEFREE
C0340427	Familial dilated cardiomyopathy	disease	BEFREE
C0340908	Arteriovenous fistula stenosis	disease	BEFREE
C0342443	Adrenal Cushing's syndrome	disease	BEFREE
C0342488	Mineralocorticoid Excess Syndrome, Apparent	disease	BEFREE
C0345967	Malignant mesothelioma	disease	BEFREE
C0349649	Pulmonary lymphangioleiomyomatosis	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0376545	Hematologic Neoplasms	group	BEFREE
C0392885	High density lipoprotein measurement	phenotype	GWASDB
C0393561	Subcortical Vascular Dementia	disease	BEFREE
C0398623	Thrombophilia	disease	BEFREE
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE
C0403440	Thin basement membrane disease	disease	BEFREE
C0403447	Chronic Kidney Insufficiency	disease	BEFREE
C0424295	Hyperactive behavior	phenotype	BEFREE
C0424688	Small head	phenotype	HPO
C0442874	Neuropathy	group	BEFREE
C0451819	Simple obesity	disease	BEFREE
C0497327	Dementia	disease	BEFREE
C0520679	Sleep Apnea, Obstructive	disease	BEFREE
C0524620	Metabolic Syndrome X	disease	BEFREE
C0524851	Neurodegenerative Disorders	group	BEFREE
C0524910	Hepatitis C, Chronic	disease	BEFREE
C0546817	Fluid overload	phenotype	BEFREE
C0565599	Maternal hypertension	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0597048	Neurogenic hypertension	disease	BEFREE
C0598428	genetic hypertension	disease	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0740394	Hyperuricemia	disease	BEFREE;HPO
C0741949	Cardiovascular Pathology	disease	BEFREE
C0745103	Hyperlipoproteinemia Type IIa	disease	BEFREE
C0745136	Hypertensive emergency	disease	BEFREE
C0745138	Hypertensive urgency	disease	BEFREE
C0747845	early pregnancy	phenotype	BEFREE
C0748318	Progressive renal failure	phenotype	HPO
C0751406	Post-Traumatic Osteoporosis	disease	CTD_human
C0751674	Lymphangioleiomyomatosis	disease	BEFREE
C0751955	Brain Infarction	disease	BEFREE
C0812413	Malignant Pleural Mesothelioma	disease	BEFREE
C0848548	hypertensive nephropathy	disease	BEFREE
C0852733	Completed Suicide	phenotype	BEFREE
C0853897	Diabetic Cardiomyopathies	disease	BEFREE
C0856169	Endothelial dysfunction	phenotype	BEFREE
C0857122	Hyponatraemic	disease	BEFREE
C0872084	Sarcopenia	phenotype	BEFREE
C0878544	Cardiomyopathies	group	BEFREE
C0878787	Growth failure	phenotype	BEFREE
C0917798	Cerebral Ischemia	disease	BEFREE
C0917996	Cerebral Aneurysm	disease	BEFREE
C0920646	Ischemia of kidney	disease	BEFREE
C0948008	Ischemic stroke	disease	BEFREE
C0948896	Primary hypogonadism	disease	BEFREE
C1096293	Macroangiopathy	disease	BEFREE
C1135196	Heart Failure, Diastolic	disease	BEFREE
C1145628	Autonomic nervous system disorders	group	BEFREE
C1260386	Glucocorticoid-remediable aldosteronism	disease	BEFREE
C1260873	Aortic valve disorder	group	BEFREE
C1269683	Major Depressive Disorder	disease	BEFREE
C1290398	Cerebral arterial aneurysm	disease	BEFREE
C1301700	Cardiovascular morbidity	phenotype	BEFREE
C1328479	Pancreatic Endocrine Carcinoma	disease	BEFREE
C1328504	Hormone refractory prostate cancer	disease	BEFREE
C1334274	Invasive Carcinoma	phenotype	BEFREE
C1383860	Cardiac Hypertrophy	phenotype	CTD_human
C1384514	Conn Syndrome	disease	BEFREE
C1397307	Cardiac fibrosis	disease	BEFREE
C1445957	Serum total cholesterol measurement	phenotype	GWASDB
C1449842	Pseudohypoaldosteronism, Type I, Autosomal Dominant	disease	BEFREE
C1449844	Pseudohypoaldosteronism, Type II	disease	BEFREE
C1504438	Cerebral artery stenosis	disease	BEFREE
C1519670	Tumor Angiogenesis	phenotype	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1536220	ST segment elevation myocardial infarction	disease	BEFREE
C1561643	Chronic Kidney Diseases	group	BEFREE;HPO
C1565489	Renal Insufficiency	disease	BEFREE
C1567435	Polycystic Kidney - body part	phenotype	BEFREE
C1567741	Alport Syndrome	disease	BEFREE
C1567742	Alport Syndrome, X-Linked	disease	BEFREE
C1611743	Familial (FPAH)	disease	BEFREE
C1623038	Cirrhosis	disease	BEFREE;CTD_human
C1696708	Prehypertension	disease	BEFREE
C1704272	Benign Prostatic Hyperplasia	disease	BEFREE
C1849300	Widely patent fontanelles and sutures	phenotype	HPO
C1857276	Trichohepatoenteric Syndrome	disease	BEFREE
C1858395	Tubular atrophy	phenotype	HPO
C1861861	CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder)	disease	BEFREE
C1862170	Brachydactyly with hypertension	disease	BEFREE
C1864100	PSEUDOHYPOPARATHYROIDISM, TYPE IB	disease	BEFREE
C1868112	Crossed Polydactyly, Type I	disease	BEFREE
C1868682	Paroxysmal kinesigenic choreoathetosis	disease	BEFREE
C1955743	Mineralocorticoid deficiency	disease	BEFREE
C1956346	Coronary Artery Disease	disease	BEFREE
C1959583	Myocardial Failure	disease	CTD_human
C1961112	Heart Decompensation	phenotype	CTD_human
C1968949	Cakut	disease	GENOMICS_ENGLAND
C1969372	Tubulointerstitial fibrosis	disease	HPO
C2062372	Adrenal hyperplasia, bilateral	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE
C2242703	Cardio-Renal Syndrome	disease	BEFREE
C2316810	Chronic kidney disease stage 5	disease	BEFREE
C2678367	Renal Tubular Dysgenesis With Choanal Atresia And Athelia	disease	CTD_human;ORPHANET;UNIPROT
C2733158	Cerebral Small Vessel Diseases	group	BEFREE
C2751310	Hyperuricemic Nephropathy, Familial Juvenile 2	disease	BEFREE;CLINVAR;CTD_human;ORPHANET;UNIPROT
C2960127	Heart failure with normal ejection fraction	disease	BEFREE
C3274516	Single Ventricle Defect	disease	BEFREE
C3275899	Hyperechogenic kidneys	phenotype	HPO
C3550658	Maternal oligohydramnios	phenotype	HPO
C3713420	Familial Hyperaldosteronism	disease	BEFREE
C3714581	Multicystic Dysplastic Kidney	disease	BEFREE
C3854315	Pseudoprimary hyperaldosteronism	disease	BEFREE
C3887486	Interstitial lung fibrosis	phenotype	BEFREE
C3887499	Renal cyst	phenotype	BEFREE
C3887896	Primary Adrenal Insufficiency	disease	BEFREE
C3887949	Apparent mineralocorticoid excess	disease	BEFREE
C4016362	HYPERPRORENINEMIA, FAMILIAL	phenotype	CLINVAR
C4020855	Respiratory function loss	phenotype	HPO
C4020969	Inflammatory abnormality of the eye	disease	BEFREE
C4021790	Abnormality of the skeletal system	phenotype	BEFREE
C4049702	Focal Segmental Glomerulosclerosis, Not Otherwise Specified	disease	BEFREE
C4476544	Tubulointerstitial scarring	phenotype	HPO
C4511620	Autosomal dominant tubulointerstitial kidney disease	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0004190	aspartic-type endopeptidase activity	EXP
GO:0004190	aspartic-type endopeptidase activity	IDA
GO:0004190	aspartic-type endopeptidase activity	IBA
GO:0005102	signaling receptor binding	IPI
GO:0005159	insulin-like growth factor receptor binding	IEA
GO:0005515	protein binding	IPI
GO:0008233	peptidase activity	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001822	kidney development	IMP
GO:0001823	mesonephros development	IEA
GO:0002003	angiotensin maturation	IDA
GO:0002003	angiotensin maturation	IBA
GO:0002003	angiotensin maturation	TAS
GO:0002018	renin-angiotensin regulation of aldosterone production	IEA
GO:0006508	proteolysis	IDA
GO:0006508	proteolysis	IBA
GO:0008217	regulation of blood pressure	TAS
GO:0008584	male gonad development	IEA
GO:0009755	hormone-mediated signaling pathway	IEA
GO:0032496	response to lipopolysaccharide	IEA
GO:0035690	cellular response to drug	IEA
GO:0035902	response to immobilization stress	IEA
GO:0042756	drinking behavior	IEA
GO:0043408	regulation of MAPK cascade	IDA
GO:0048469	cell maturation	IEA
GO:0050435	amyloid-beta metabolic process	IEA
GO:0051591	response to cAMP	IEA
GO:0070305	response to cGMP	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005615	extracellular space	IBA
GO:0005737	cytoplasm	IEA
GO:0005886	plasma membrane	TAS
GO:0045177	apical part of cell	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-392499	Metabolism of proteins	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
D015056	1-Methyl-3-isobutylxanthine	[Sodium, Dietary deficiency results in increased susceptibility to 1-Methyl-3-isobutylxanthine] which results in increased secretion of REN protein	10432392
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of REN mRNA	30723492
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of REN mRNA	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of REN mRNA	19114083
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein	9300315
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]	9300315
C004504	2-bromoethylamine	2-bromoethylamine results in increased expression of REN protein	19463747
C076864	2-hexynyladenosine-5'-N-ethylcarboxamide	2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein	9300315
C076864	2-hexynyladenosine-5'-N-ethylcarboxamide	Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
C076864	2-hexynyladenosine-5'-N-ethylcarboxamide	spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
C585004	2-monochloropropanediol	2-monochloropropanediol results in increased expression of REN mRNA	28522335
C026708	2-phenylaminoadenosine	2-phenylaminoadenosine results in increased activity of REN protein	2203898
D012368	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D012368	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in increased secretion of REN protein	9256163
D000070	Acebutolol	Acebutolol results in decreased activity of REN protein	6118215
D000070	Acebutolol	Acebutolol results in decreased activity of REN protein	6110712
D000079	Acetaldehyde	[Acetaldehyde co-treated with Cyanamide] results in increased activity of REN protein	26298003
D000082	Acetaminophen	Acetaminophen results in increased activity of REN protein	1825077
D000082	Acetaminophen	Acetaminophen results in increased expression of REN protein	455818
D000082	Acetaminophen	ALB protein inhibits the reaction [Acetaminophen results in increased activity of REN protein]	1825077
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
D000241	Adenosine	Adenosine results in decreased secretion of REN protein	3044993
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of REN gene	27153756
D000420	Albuterol	Albuterol results in increased expression of REN protein	2829953
D000450	Aldosterone	[AGT co-treated with REN] results in increased abundance of Aldosterone	18679781
D000450	Aldosterone	candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
D000450	Aldosterone	Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
C446481	aliskiren	[aliskiren co-treated with Atenolol] results in decreased activity of REN protein	18957387
C446481	aliskiren	aliskiren results in decreased activity of REN protein	18957387
C446481	aliskiren	aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]	27645307
C446481	aliskiren	aliskiren results in decreased activity of REN protein	15662231; 18802783;
D000526	Alprenolol	Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]	923630
D000526	Alprenolol	Alprenolol results in decreased expression of REN protein	923630
D000527	Alprostadil	Alprostadil results in increased expression of REN protein	9195357
C001864	aluminum phosphide	aluminum phosphide results in increased activity of REN protein	2200784
D017311	Amlodipine	Amlodipine results in increased expression of REN protein	10218729
D017311	Amlodipine	[Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein	11078175
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of REN mRNA	16483693
D000666	Amphotericin B	Amphotericin B results in decreased secretion of REN protein	7391978
D019162	Anesthetics, Combined	Anesthetics, Combined results in increased activity of REN protein	453612; 7020487;
D019162	Anesthetics, Combined	Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]	453612; 7020487;
D019162	Anesthetics, Combined	Propranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]	7020487
D019162	Anesthetics, Combined	Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]	7020487
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	6257882
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein	6185789
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]	3326920
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	1647690; 3071592; 3152422; 3326920; 6280486; 6290435; 6324834;
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of and affects the activity of REN protein	7000102
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of and results in increased activity of REN protein	6105291
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN protein	1668233; 6168412; 6388325;
D000806	Angiotensin-Converting Enzyme Inhibitors	Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	3326920
D000806	Angiotensin-Converting Enzyme Inhibitors	AGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]	3078272
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	231700; 9140837; 9201321;
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN mRNA	1330361; 9533614;
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN protein	1330361; 9533614;
D000806	Angiotensin-Converting Enzyme Inhibitors	Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	6753910
D000959	Antihypertensive Agents	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D001241	Aspirin	Aspirin results in decreased activity of REN protein	19805643; 7994448;
D001262	Atenolol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D001262	Atenolol	[aliskiren co-treated with Atenolol] results in decreased activity of REN protein	18957387
D001262	Atenolol	Atenolol results in decreased activity of REN protein	18957387; 3333524;
D001262	Atenolol	Atenolol results in decreased expression of REN protein	14639093
D001262	Atenolol	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D001262	Atenolol	Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]	9300315
D001262	Atenolol	Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
D001262	Atenolol	Atenolol results in decreased expression of REN protein	9300315
D001262	Atenolol	Atenolol results in decreased activity of REN protein	6756707
C044946	benazepril	[benazepril co-treated with Valsartan] results in increased activity of REN protein	10836730
C044946	benazepril	benazepril results in increased expression of REN protein	1316404
C044946	benazepril	[benazepril co-treated with Valsartan] results in increased activity of REN protein	11501062
C044946	benazepril	benazepril results in increased activity of REN protein	11501062
D001539	Bendroflumethiazide	Bendroflumethiazide results in increased expression of REN protein	62162
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of REN gene	28505145
C006780	bisphenol A	bisphenol A results in increased expression of REN mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of REN gene	28505145
C014926	BQ 22-708	BQ 22-708 results in increased activity of REN protein	7018762
D003994	Bucladesine	Bucladesine results in increased expression of REN mRNA	9256163
D003994	Bucladesine	Bucladesine results in increased secretion of REN protein	9256163
D002034	Bumetanide	[Bumetanide co-treated with trandolapril] results in increased expression of REN protein	16635047
D002034	Bumetanide	Bumetanide results in increased expression of REN protein	16635047
D002034	Bumetanide	Bumetanide results in increased secretion of REN protein	7040495
D002034	Bumetanide	Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]	6756707
D002034	Bumetanide	Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]	7040495
D002034	Bumetanide	Bumetanide results in increased expression of REN mRNA	14504926
C084811	bunitrolol	bunitrolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6113146
C059042	BW 175	BW 175 binds to and results in decreased activity of REN protein	8149456
D002110	Caffeine	Caffeine results in increased activity of REN protein	8244516
D002110	Caffeine	Caffeine results in increased activity of REN protein	1860718; 3020089;
D002110	Caffeine	Caffeine results in increased expression of REN protein	3044993
D002110	Caffeine	Caffeine results in increased secretion of REN protein	10803761
D002117	Calcitriol	Calcitriol results in decreased activity of REN protein	10052739
D002118	Calcium	Calcium results in decreased secretion of REN protein	9618396
D002118	Calcium	[[Calcium results in increased activity of MYLK protein] which results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein	9618396
D002118	Calcium	ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein]	9618396
C059041	calyculin A	calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]	9618396
C059041	calyculin A	[calyculin A results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein	9618396
C081643	candesartan	candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
C081643	candesartan	candesartan results in decreased activity of REN protein	18679781
C081643	candesartan	candesartan results in increased expression of REN mRNA	18796534; 19047581;
D000077261	Carvedilol	Carvedilol results in decreased expression of REN protein	2454358
D000077261	Carvedilol	Carvedilol results in decreased activity of REN protein	1974513
D000077261	Carvedilol	Carvedilol results in decreased expression of REN protein	2454359
D000068579	Celecoxib	Celecoxib results in decreased expression of REN protein	10742298
D002714	Chlorisondamine	Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D002752	Chlorthalidone	Chlorthalidone results in increased activity of REN protein	1116335; 3319646;
D002752	Chlorthalidone	Chlorthalidone results in increased expression of REN protein modified form	796642
D017315	Cilazapril	Cilazapril results in increased activity of REN protein	2419701
D017315	Cilazapril	Cilazapril results in increased activity of REN protein	2425185
D003000	Clonidine	Clonidine results in decreased activity of REN protein	6991409
D003000	Clonidine	Clonidine results in decreased secretion of and results in decreased activity of REN protein	6248808
D003000	Clonidine	[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein	12014310
D003000	Clonidine	Clonidine results in decreased activity of REN protein	238481; 6337028; 998518;
D003000	Clonidine	Clonidine results in decreased expression of REN protein	20833658; 3913757;
D003000	Clonidine	Clonidine results in increased activity of REN protein	3007707; 7837211;
D005576	Colforsin	Colforsin results in increased expression of REN mRNA	9256163
D005576	Colforsin	Colforsin results in increased secretion of REN protein	9256163
D005576	Colforsin	[Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein	10432392
D003276	Contraceptives, Oral	Contraceptives, Oral results in increased activity of REN protein	1122661; 45830;
D003471	Cuprizone	Cuprizone affects the expression of REN mRNA	27523638
D003484	Cyanamide	[Acetaldehyde co-treated with Cyanamide] results in increased activity of REN protein	26298003
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D016572	Cyclosporine	Cyclosporine affects the expression of REN protein	1851318
D016572	Cyclosporine	Cyclosporine results in decreased activity of REN protein	3300326
D016572	Cyclosporine	Cyclosporine results in increased expression of REN mRNA	21865292
D016572	Cyclosporine	Cyclosporine results in increased expression of REN protein	21865292; 7532090;
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D000077335	Desflurane	[Propofol co-treated with Desflurane] results in increased expression of REN protein	8017643
D003900	Desoxycorticosterone	[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein	11039
D003907	Dexamethasone	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D003907	Dexamethasone	Dexamethasone results in increased activity of REN protein	174842
D003907	Dexamethasone	Dexamethasone results in increased secretion of REN protein	3074918
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of REN mRNA	26924002
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of REN protein	22677342
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased activity of REN protein	45830
D004078	Dihydralazine	Dihydralazine results in increased activity of REN protein	3383316
D004110	Diltiazem	Diltiazem results in increased expression of REN protein	2222951
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of REN mRNA	26924002
D015232	Dinoprostone	Dinoprostone results in increased expression of REN protein	495730
D015232	Dinoprostone	[Sodium, Dietary deficiency results in increased susceptibility to Dinoprostone] which results in increased secretion of REN protein	10432392
D004232	Diuretics	Diuretics results in increased expression of REN protein	62162
D004280	Dobutamine	Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D004280	Dobutamine	Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D004280	Dobutamine	Dobutamine results in increased activity of REN protein	9209250
D004280	Dobutamine	Dobutamine results in increased expression of REN mRNA	9203624
D004280	Dobutamine	Dobutamine results in increased secretion of REN protein	9203624
D017292	Doxazosin	Doxazosin results in increased expression of REN protein	7818152
D013759	Dronabinol	Dronabinol affects the methylation of REN gene	26044905
D004656	Enalapril	[Enalapril co-treated with FR 173657] results in increased activity of REN protein	12019275
D004656	Enalapril	Enalapril results in increased activity of REN protein	12019275
D004656	Enalapril	Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
D004656	Enalapril	Enalapril results in decreased activity of REN protein	18679781
D004656	Enalapril	Enalapril results in increased expression of REN protein	2994932
D004656	Enalapril	[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein	11078175
D004656	Enalapril	Enalapril results in increased expression of REN mRNA	19536436; 19767874; 21424707;
D004656	Enalapril	Enalapril results in increased expression of REN protein	19536436; 19767874;
D004656	Enalapril	Enalapril results in increased secretion of REN protein	19109587; 19536436;
D004656	Enalapril	GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]	19109587
D004656	Enalapril	GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]	19109587
D004656	Enalapril	REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]	17846348
D004656	Enalapril	[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA	17846348
D004656	Enalapril	Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]	19536436
D004656	Enalapril	Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]	19536436
D004656	Enalapril	Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]	19536436
D004656	Enalapril	Enalapril results in increased activity of REN protein	6094050
D004656	Enalapril	Enalapril results in increased expression of REN mRNA	12434137; 1330361; 18796534; 21423293;
D004656	Enalapril	Enalapril results in increased expression of REN protein	12434137; 1330361;
D015773	Enalaprilat	Enalaprilat results in increased expression of REN mRNA	21795644
D004837	Epinephrine	Epinephrine results in increased activity of REN protein	6314140; 8592096;
D004837	Epinephrine	ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein]	6314140
C036604	esmolol	esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	2569849
D004967	Estrogens	Estrogens results in decreased expression of REN protein	185040
D004966	Estrogens, Conjugated (USP)	Estrogens, Conjugated (USP) results in increased activity of REN protein	45830
D000431	Ethanol	Ethanol results in increased activity of REN protein	22982071
D000431	Ethanol	Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]	22982071
D004997	Ethinyl Estradiol	AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased activity of REN protein]	11095476
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased activity of REN protein	11095476
D004997	Ethinyl Estradiol	Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]	11095476
D005280	Fenoterol	Fenoterol results in increased activity of REN protein	9209250
D005280	Fenoterol	Fenoterol results in increased expression of REN protein	2829953
D005283	Fentanyl	[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein	3284271
C105311	FR 173657	[Enalapril co-treated with FR 173657] results in increased activity of REN protein	12019275
D005665	Furosemide	Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]	11095476
D005665	Furosemide	Furosemide results in increased activity of REN protein	11046100; 1924052; 599795;
D005665	Furosemide	Furosemide results in increased expression of REN protein	3530574; 4028619;
D005665	Furosemide	Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]	3530574; 4028619;
D005665	Furosemide	Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]	1924052
D005665	Furosemide	Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]	4028619
D005665	Furosemide	Furosemide results in increased expression of REN mRNA	15976003
D005665	Furosemide	Furosemide results in increased expression of REN protein	15976003
D005665	Furosemide	PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]	15976003
D005665	Furosemide	PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]	15976003
D005665	Furosemide	Furosemide results in increased activity of REN protein	10604960; 11135058;
D005665	Furosemide	Furosemide results in increased expression of REN mRNA	11135058; 8418022;
D005665	Furosemide	Furosemide results in increased expression of REN protein	7954537
D005665	Furosemide	Furosemide results in increased secretion of REN protein	8418022
D005665	Furosemide	Furosemide results in increased activity of REN protein	3893163
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of REN gene	28505145
D019833	Genistein	Genistein inhibits the reaction [EGF protein results in decreased secretion of REN protein]	8491500
D005839	Gentamicins	Gentamicins results in increased expression of REN protein	8160791
D005947	Glucose	Glucose results in increased expression of REN mRNA	19861503
D005947	Glucose	Glucose results in increased expression of REN protein	19861503
C004312	glycidol	glycidol results in decreased expression of REN mRNA	24915197
D006034	Glycyrrhetinic Acid	Glycyrrhetinic Acid results in decreased activity of REN protein	20460744
D019695	Glycyrrhizic Acid	Glycyrrhizic Acid results in decreased activity of REN protein	20460744
D016316	Guanfacine	Guanfacine results in decreased activity of REN protein	1305723; 3520085;
D006221	Halothane	[Halothane co-treated with Nitroprusside] results in increased activity of REN protein	3281763
D006830	Hydralazine	Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]	923630
D006830	Hydralazine	Hydralazine results in increased activity of REN protein	3154321
D006830	Hydralazine	Hydralazine results in increased expression of REN protein	2953239; 923630;
D006830	Hydralazine	Hydralazine results in increased activity of REN protein	2203898; 231700;
D006852	Hydrochlorothiazide	Hydrochlorothiazide results in increased activity of REN protein	1930859; 2920503;
D006852	Hydrochlorothiazide	Hydrochlorothiazide results in increased expression of REN protein	12569265
D006852	Hydrochlorothiazide	Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]	12569265
D006852	Hydrochlorothiazide	Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]	1930859
D006852	Hydrochlorothiazide	Hydrochlorothiazide results in increased activity of REN protein	11135058
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of REN protein	15743397; 7473517;
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of REN protein]	28578904
C026777	ICI 118551	ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein]	6314140
D007190	Indapamide	Indapamide results in increased expression of REN protein	6578003
D007200	Indican	Indican results in increased expression of REN mRNA	25056788
D007213	Indomethacin	[Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein	11078175
D007213	Indomethacin	[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein	11078175
D007213	Indomethacin	Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]	6756707
D007213	Indomethacin	Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]	3530574; 4028619;
D007213	Indomethacin	Indomethacin results in decreased activity of REN protein	3884224; 7035040; 7049707; 929154;
D007213	Indomethacin	Indomethacin results in decreased expression of and results in decreased activity of REN protein	6756707
D007213	Indomethacin	Indomethacin results in decreased expression of REN protein	119300; 3530574; 4028619; 6758745;
D007213	Indomethacin	[Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein	7049707
D007213	Indomethacin	aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]	27645307
D007213	Indomethacin	Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	6753910
D007213	Indomethacin	Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D007213	Indomethacin	Indomethacin results in decreased activity of REN protein	439781
D007213	Indomethacin	Indomethacin results in increased expression of REN protein	27645307
C002587	ioxitalamic acid	Acetylcysteine inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
C002587	ioxitalamic acid	ioxitalamic acid results in increased expression of REN protein	19945959
C002587	ioxitalamic acid	Propranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
D000077405	Irbesartan	Irbesartan results in increased expression of REN protein	14639093
D007530	Isoflurane	[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein	3284271
D007530	Isoflurane	Isoflurane affects the activity of REN protein	3281763
D007530	Isoflurane	[Labetalol co-treated with Isoflurane] results in increased expression of REN protein	1897344
D007545	Isoproterenol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	Isoproterenol results in increased activity of REN protein	6103674
D007545	Isoproterenol	Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	Isoproterenol results in increased activity of REN protein	6314140
D007545	Isoproterenol	Isoproterenol results in increased expression of REN protein	1653766
D007545	Isoproterenol	Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein]	1653766
D007545	Isoproterenol	Isoproterenol promotes the reaction [CD38 gene mutant form results in increased activity of REN protein]	23343681
D007545	Isoproterenol	Isoproterenol results in increased expression of REN mRNA	21424707
D007545	Isoproterenol	Isoproterenol results in increased secretion of REN protein	3515047
D007545	Isoproterenol	[Sodium, Dietary deficiency results in increased susceptibility to Isoproterenol] which results in increased secretion of REN protein	10432392
D007545	Isoproterenol	Isoproterenol results in increased expression of REN protein	11709406; 9539862;
D007545	Isoproterenol	Isoproterenol results in increased secretion of REN protein	3910304
D007545	Isoproterenol	Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D007545	Isoproterenol	Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D007545	Isoproterenol	Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]	9539862
D007545	Isoproterenol	Isoproterenol results in increased activity of REN protein	7804848
D007556	Isoxsuprine	Isoxsuprine results in increased activity of REN protein	31167
D017275	Isradipine	Isradipine results in increased activity of REN protein	2550243
D007649	Ketamine	Ketamine results in increased expression of REN protein	6349867
D007654	Ketoconazole	Ketoconazole results in decreased expression of REN protein	2632720
D007660	Ketoprofen	Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]	1924052
D007741	Labetalol	[Labetalol co-treated with Isoflurane] results in increased expression of REN protein	1897344
D007741	Labetalol	Labetalol results in decreased activity of REN protein	2524958; 7013770; 7988622;
D019344	Lactic Acid	Lactic Acid results in decreased expression of REN mRNA	30851411
D008070	Lipopolysaccharides	[IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D017706	Lisinopril	Lisinopril results in increased expression of REN protein	2550029
D017706	Lisinopril	Lisinopril results in increased expression of REN mRNA	8915971
D019808	Losartan	Losartan results in increased expression of REN protein	10483973
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]	28578904
D019808	Losartan	Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]	12569265
D019808	Losartan	[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein	9124547
D019808	Losartan	Losartan results in increased activity of REN protein	7965263; 8403307;
D019808	Losartan	Losartan results in increased expression of REN protein	8423551
D019808	Losartan	Losartan results in increased expression of REN protein	9245700
D019808	Losartan	Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]	22982071
D019808	Losartan	Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D019808	Losartan	Losartan results in increased activity of REN protein	9431853
D019808	Losartan	Losartan results in increased expression of REN mRNA	9431853; 9533614;
D019808	Losartan	Losartan results in increased expression of REN protein	12013499; 1387008; 8382237; 9533614;
C066026	losartan carboxylic acid	losartan carboxylic acid results in increased expression of REN protein	10483973
D008278	Magnesium Sulfate	Magnesium Sulfate results in increased activity of REN protein	1874207
D008469	Meclofenamic Acid	Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
C545385	Mequindox	Mequindox affects the expression of REN mRNA	20553828
D008731	Methoxychlor	Methoxychlor results in increased methylation of REN gene	23303685
D008750	Methyldopa	Methyldopa results in decreased activity of REN protein	145319
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of REN mRNA	23179753
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of REN protein	26612503
D008775	Methylprednisolone	Methylprednisolone results in increased activity of REN protein	235222; 6277579;
D008775	Methylprednisolone	Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]	235222
D008790	Metoprolol	Metoprolol results in decreased expression of REN protein	2454358
D008790	Metoprolol	Metoprolol results in decreased expression of REN mRNA	8203557
D008914	Minoxidil	Minoxidil affects the expression of REN protein	28811
D008914	Minoxidil	Minoxidil binds to and results in decreased activity of REN protein	790007
D008914	Minoxidil	Minoxidil results in increased activity of REN protein	145319
D008914	Minoxidil	Minoxidil results in increased expression of REN protein	8238566
C070571	ML 7	calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]	9618396
C070571	ML 7	ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein]	9618396
C070571	ML 7	[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein	9618396
C070571	ML 7	ML 7 results in increased secretion of REN protein	9618396
C470272	momordin II (Oleanolic Acid)	momordin II (Oleanolic Acid) results in decreased activity of REN protein	20460744
C408362	momordin I (Oleanolic Acid)	momordin I (Oleanolic Acid) results in decreased activity of REN protein	20460744
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of REN mRNA	26924002
D009270	Naloxone	Naloxone results in increased activity of REN protein	3157294
D009288	Naproxen	Naproxen results in decreased activity of REN protein	2203262
D000068577	Nebivolol	Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein]	12806161
D009529	Nicardipine	Nicardipine results in increased activity of REN protein	1867428
D009543	Nifedipine	Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]	3326920
D009543	Nifedipine	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D009543	Nifedipine	Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	3326920
D009543	Nifedipine	Nifedipine results in increased activity of REN protein	3326920; 6184561; 6354932;
D009543	Nifedipine	Nifedipine results in increased expression of REN protein	3313686
D009543	Nifedipine	Nifedipine results in increased activity of REN protein	3544790
C035100	nilvadipine	nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]	7533848
D009568	Nitrendipine	Nitrendipine results in increased activity of REN protein	2869952; 6734029;
D009569	Nitric Oxide	Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein]	12806161
D009569	Nitric Oxide	[Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein	7541960
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of REN protein	10679504; 15123544;
C007350	nitrofen	nitrofen results in decreased expression of REN mRNA	16292651
D005996	Nitroglycerin	Nitroglycerin results in decreased activity of REN protein	8640982
D005996	Nitroglycerin	Nitroglycerin results in increased activity of REN protein	9527094
D009599	Nitroprusside	Nitroprusside results in increased activity of REN protein	2434793; 6399253;
D009599	Nitroprusside	bunitrolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6113146
D009599	Nitroprusside	esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	2569849
D009599	Nitroprusside	[Halothane co-treated with Nitroprusside] results in increased activity of REN protein	3281763
D009599	Nitroprusside	Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]	453612; 7020487;
D009599	Nitroprusside	Nitroprusside results in increased activity of REN protein	1867428; 2413294; 2569849; 3152422; 6113146; 6434220; 7351115;
D009599	Nitroprusside	Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]	7020487
D009599	Nitroprusside	Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6434220
D009599	Nitroprusside	Nitroprusside affects the reaction [Sodium affects the activity of REN protein]	7009830
D009638	Norepinephrine	Norepinephrine results in increased activity of REN protein	8952593
D010042	Ouabain	Ouabain results in decreased secretion of REN protein	6093556
D010042	Ouabain	Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]	6093556
D010096	Oxprenolol	[Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein	7049707
D010096	Oxprenolol	Oxprenolol results in decreased activity of REN protein	6173514; 6344036; 7023672; 7049707;
D010424	Pentobarbital	Pentobarbital results in increased activity of REN protein	6348358
D010424	Pentobarbital	Pentobarbital results in increased activity of REN protein	3512818
D020913	Perindopril	Perindopril results in increased activity of REN protein	2549899; 2605800;
D020913	Perindopril	Perindopril results in increased expression of REN protein	9383173
D010646	Phentolamine	Phentolamine results in increased activity of REN protein	6173514
D010656	Phenylephrine	Phenylephrine results in increased secretion of REN protein	6347479
D010656	Phenylephrine	Phenylephrine results in decreased activity of REN protein	2847676
D010869	Pindolol	Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D010869	Pindolol	Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]	7104148
D010869	Pindolol	Pindolol results in decreased activity of REN protein	791319
D010869	Pindolol	Pindolol results in decreased expression of REN protein	973972
D010880	Piperidines	Piperidines analog results in decreased activity of REN protein	18679781
D010936	Plant Extracts	Plant Extracts results in decreased expression of REN mRNA	23557933
D011217	Practolol	Practolol results in decreased activity of REN protein	6110712
D011224	Prazosin	Prazosin results in decreased activity of REN protein	7023672
D011224	Prazosin	Prazosin results in increased activity of REN protein	6173514; 6258839; 7023672;
D011224	Prazosin	Prazosin results in increased transport of REN protein	3539430
D011224	Prazosin	Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]	3539430
D011339	Probenecid	Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]	7040495
D015742	Propofol	[Propofol co-treated with Desflurane] results in increased expression of REN protein	8017643
D011433	Propranolol	Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D011433	Propranolol	Propranolol results in decreased activity of REN protein	2566282
D011433	Propranolol	Propranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]	7020487
D011433	Propranolol	Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]	7020487
D011433	Propranolol	Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein]	1653766
D011433	Propranolol	Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6434220
D011433	Propranolol	Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]	7104148
D011433	Propranolol	Propranolol results in decreased activity of REN protein	1103606; 6346849; 637424; 791319; 7988622;
D011433	Propranolol	Propranolol results in decreased expression of REN protein	200433; 653302;
D011433	Propranolol	Propranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
D011433	Propranolol	Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]	3539430
D011433	Propranolol	Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D011433	Propranolol	Propranolol results in decreased activity of REN protein	145319; 6110712;
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein	8446257
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of REN protein	9171944
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN protein	2236972
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of REN protein	2267444
D011794	Quercetin	Quercetin inhibits the reaction [EGF protein results in decreased secretion of REN protein]	8491500
D000077583	Quinapril	Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D000077583	Quinapril	Quinapril results in increased expression of REN protein	10334802
D017257	Ramipril	Ramipril results in increased activity of REN protein	1327051
D017257	Ramipril	Ramipril results in increased expression of REN mRNA	14504926
D017257	Ramipril	Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]	9539862
D017257	Ramipril	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]	11832429
D017257	Ramipril	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]	11832429
D017257	Ramipril	Ramipril results in increased expression of REN protein	9179393
D011899	Ranitidine	Ranitidine affects the activity of REN protein	1972605
D000077593	Reboxetine	Reboxetine results in decreased activity of REN protein	16717144
C065581	remikiren	remikiren results in decreased activity of REN protein	15662231
C013672	riddelliine	riddelliine results in increased expression of REN mRNA	18047727
D000077769	Rilmenidine	Rilmenidine results in decreased activity of REN protein	2866274
D012312	Ritodrine	Ritodrine results in increased activity of REN protein	31167
D000068677	Sildenafil Citrate	Sildenafil Citrate results in increased activity of REN protein	15613622
D012834	Silver	Silver results in decreased expression of REN mRNA	26277626
D020123	Sirolimus	Sirolimus results in increased expression of REN mRNA	21865292
D012964	Sodium	Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]	1930859
D012964	Sodium	Sodium deficiency results in increased activity of REN protein	11299228
D012964	Sodium	Sodium deficiency results in increased expression of REN mRNA	19767874
D012964	Sodium	Sodium deficiency results in increased expression of REN protein	19767874
D012964	Sodium	Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]	19536436
D012964	Sodium	Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]	19536436
D012964	Sodium	Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]	19536436
D012964	Sodium	Sodium results in decreased expression of REN mRNA	19536436
D012964	Sodium	Sodium results in decreased expression of REN protein	19536436
D012964	Sodium	Sodium results in decreased secretion of REN protein	19536436
D012964	Sodium	Nitroprusside affects the reaction [Sodium affects the activity of REN protein]	7009830
D012964	Sodium	Sodium affects the activity of REN protein	7009830
D012964	Sodium	Sodium affects the expression of REN mRNA	12424424
D012965	Sodium Chloride	GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]	19474190
D012965	Sodium Chloride	REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]	17846348
D012965	Sodium Chloride	[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA	17846348
D012965	Sodium Chloride	Sodium Chloride deficiency results in increased expression of REN mRNA	19474190
D012965	Sodium Chloride	[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein	11039
D012965	Sodium Chloride	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]	11832429
D012965	Sodium Chloride	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]	11832429
D012965	Sodium Chloride	Sodium Chloride deficiency results in increased activity of REN protein	11832429
D012965	Sodium Chloride	Sodium Chloride deficiency results in increased expression of REN mRNA	11832429
D012965	Sodium Chloride	Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]	235222
D017673	Sodium Chloride, Dietary	[AGTR1A co-treated with Sodium Chloride, Dietary] results in decreased expression of REN mRNA	21424707
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary affects the expression of REN mRNA	14504926
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN mRNA]	26781276
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN protein]	26781276
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary results in decreased expression of REN mRNA	21424707
D017673	Sodium Chloride, Dietary	[Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein	7541960
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary deficiency results in increased activity of REN protein	10432392
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary results in decreased activity of REN protein	10432392
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary results in decreased expression of REN mRNA	18796534; 19211690;
D017673	Sodium Chloride, Dietary	Sodium Chloride, Dietary results in decreased expression of REN protein	19211690
D012982	Sodium, Dietary	CD38 gene mutant form promotes the reaction [Sodium, Dietary deficiency results in increased activity of REN protein]	23343681
D012982	Sodium, Dietary	Sodium, Dietary deficiency results in increased activity of REN protein	23343681
D012982	Sodium, Dietary	[Sodium, Dietary deficiency results in increased susceptibility to 1-Methyl-3-isobutylxanthine] which results in increased secretion of REN protein	10432392
D012982	Sodium, Dietary	[Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein	10432392
D012982	Sodium, Dietary	[Sodium, Dietary deficiency results in increased susceptibility to Dinoprostone] which results in increased secretion of REN protein	10432392
D012982	Sodium, Dietary	[Sodium, Dietary deficiency results in increased susceptibility to Isoproterenol] which results in increased secretion of REN protein	10432392
D012982	Sodium, Dietary	Sodium, Dietary results in decreased activity of REN protein	23343681
C056684	soyasaponin I	soyasaponin I results in decreased activity of REN protein	19060406; 20460744;
C106126	soyasaponin II	soyasaponin II results in decreased activity of REN protein	20460744
C052555	spirapril	spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
C052555	spirapril	spirapril results in increased expression of REN mRNA	1764812
C052555	spirapril	spirapril results in increased expression of REN protein	1764812; 9300315;
D013148	Spironolactone	[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein	12014310
D013148	Spironolactone	REN protein results in decreased susceptibility to Spironolactone	6998872
D013148	Spironolactone	Spironolactone results in increased expression of REN protein	20016520; 9595286;
D013467	Sulindac	Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]	4028619
D013467	Sulindac	Sulindac results in decreased activity of REN protein	2203262; 3884224;
D016559	Tacrolimus	nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]	7533848
D016559	Tacrolimus	Tacrolimus results in decreased activity of REN protein	7509514
D016559	Tacrolimus	Tacrolimus results in increased expression of REN mRNA	12469222; 21865292;
D016559	Tacrolimus	Tacrolimus results in increased expression of REN protein	7532090; 7533848;
D000077333	Telmisartan	Telmisartan results in increased expression of REN mRNA	9533614
D000077333	Telmisartan	Telmisartan results in increased expression of REN protein	9533614
D013726	Terbutaline	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D013726	Terbutaline	Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D013726	Terbutaline	Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D013726	Terbutaline	[IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D013726	Terbutaline	Terbutaline results in increased expression of REN mRNA	9203624
D013726	Terbutaline	Terbutaline results in increased secretion of REN protein	9203624; 9256163;
D013726	Terbutaline	TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D043343	Testosterone Propionate	Testosterone Propionate results in increased expression of REN mRNA	1568764
D043343	Testosterone Propionate	Testosterone Propionate results in increased expression of REN protein	1568764
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of REN mRNA	27914987
D013806	Theophylline	Theophylline affects the expression of REN protein	7743391
D013989	Ticrynafen	Ticrynafen results in increased activity of REN protein	6756707
C009495	titanium dioxide	titanium dioxide results in decreased expression of REN mRNA	26277626
C009495	titanium dioxide	titanium dioxide results in decreased expression of REN protein	26277626
D000077786	Torsemide	Torsemide results in increased expression of REN protein	7954537
C052035	trandolapril	[Bumetanide co-treated with trandolapril] results in increased expression of REN protein	16635047
C052035	trandolapril	trandolapril results in increased expression of REN protein	16635047
C052035	trandolapril	trandolapril results in increased expression of REN protein	27428043
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of REN gene	27618143
D014635	Valproic Acid	Valproic Acid results in increased methylation of REN gene	29154799
D000068756	Valsartan	[benazepril co-treated with Valsartan] results in increased activity of REN protein	10836730
D000068756	Valsartan	[benazepril co-treated with Valsartan] results in increased activity of REN protein	11501062
D000068756	Valsartan	Valsartan results in increased activity of REN protein	11501062
D000068756	Valsartan	Valsartan results in increased expression of REN protein	8505092
D014638	Vanadates	Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]	6093556
C006027	xibenolol	xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D015016	Yohimbine	Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Yohimbine results in increased expression of REN protein	6323192
C076903	zankiren hydrochloride	zankiren hydrochloride results in decreased activity of REN protein	15662231
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of REN mRNA	27504894

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0025	Alternative splicing
KW-0064	Aspartyl protease
KW-0165	Cleavage on pair of basic residues
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-1015	Disulfide bond
KW-0325	Glycoprotein
KW-0378	Hydrolase
KW-0472	Membrane
KW-0621	Polymorphism
KW-0645	Protease
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal
KW-0865	Zymogen

Interpro

InterPro ID	InterPro Term
IPR001461	Aspartic_peptidase_A1
IPR001969	Aspartic_peptidase_AS
IPR012848	Aspartic_peptidase_N
IPR033121	PEPTIDASE_A1
IPR021109	Peptidase_aspartic_dom_sf
IPR034135	Renin-like_dom

PROSITE

PROSITE ID	PROSITE Term
PS00141	ASP_PROTEASE
PS51767	PEPTIDASE_A1

Pfam

Pfam ID	Pfam Term
PF07966	A1_Propeptide
PF00026	Asp

Gene: REN

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction