Gene: ren

Basic information

Tag Content
Uniprot ID Q6XQJ0
Entrez ID
Genbank protein ID AAI62351.1; AAI62339.1; AAO41706.1;
Genbank nucleotide ID
Ensembl protein ID ENSDARP00000061335
Ensembl nucleotide ID ENSDARG00000041858
Gene name Angiotensinogenase
Gene symbol ren
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MKIHCLTLLI LSLSAISTKA LWRVKLKKMP SIRETLKEMS VTPAQVLSEI MPKYQEPSPT 60
NGTAPTPLIN YLDTQYFGEI SIGSPAQMFN VVFDTGSANL WVPSHSCSPL YTACFTHNRY 120
DASKSLTHIF NGTGFSIQYA SGNVRGFLSE DVVVVGGIPV VQVFAEATAL PAIPFIFAKF 180
DGVLGMGYPD VAIDGITPVF DRIMSQHVLK ENVFSVYYSR DPTHIPGGEL VLGGTDPNYH 240
TGPFHYINTK EQGKWEVIMK GVSVGADILF CKDGCTAVID TGSSYITGPA SSISILMKTI 300
GAVELAEGGY TVSCNVVRLL PTVAFHLGGQ EYSLTDEDYI LWQSEFGEDI CTVTFKALDV 360
PPPTGPVWIL GANFIARYYT EFDRGNNRIG FARAV 395

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologREN403838Q6DYE7Canis lupus familiarisPredictionMore>>
1:1 orthologRENA0A452ERZ4Capra hircusPredictionMore>>
1:1 orthologREN5972P00797Homo sapiensPublicationMore>>
1:1 orthologRen119701P06281Mus musculusPredictionMore>>
1:1 orthologREN469651H2R877Pan troglodytesPredictionMore>>
1:1 orthologRENA0A287APG1Sus scrofaPredictionMore>>
1:1 orthologRen124715P08424Rattus norvegicusPredictionMore>>
1:1 orthologrenQ6XQJ0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0004190 aspartic-type endopeptidase activity
GO:0002003 angiotensin maturation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0064 Aspartyl protease
KW-0378 Hydrolase
KW-0645 Protease
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR034135 Renin-like_dom

PROSITE

PROSITE ID PROSITE Term
PS00141 ASP_PROTEASE
PS51767 PEPTIDASE_A1

Pfam

Pfam ID Pfam Term
PF00026 Asp