| Tag | Content |
|---|---|
| Uniprot ID | P08424; Q63497; |
| Entrez ID | 24715 |
| Genbank protein ID | CAA30082.1; AAP13916.1; AAA42030.1; AAH78878.1; AAA42031.1; |
| Genbank nucleotide ID | NM_012642.4 |
| Ensembl protein ID | ENSRNOP00000003951 |
| Ensembl nucleotide ID | ENSRNOG00000002937 |
| Gene name | Renin |
| Gene symbol | Ren1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Sequence | MGGRRMPLWA LLLLWTSCSF SLPTDTASFG RILLKKMPSV REILEERGVD MTRISAEWGE 60 FIKKSSFTNV TSPVVLTNYL DTQYYGEIGI GTPSQTFKVI FDTGSANLWV PSTKCGPLYT 120 ACEIHNLYDS SESSSYMENG TEFTIHYGSG KVKGFLSQDV VTVGGIIVTQ TFGEVTELPL 180 IPFMLAKFDG VLGMGFPAQA VDGVIPVFDH ILSQRVLKEE VFSVYYSRES HLLGGEVVLG 240 GSDPQHYQGN FHYVSISKAG SWQITMKGVS VGPATLLCEE GCMAVVDTGT SYISGPTSSL 300 QLIMQALGVK EKRANNYVVN CSQVPTLPDI SFYLGGRTYT LSNMDYVQKN PFRNDDLCIL 360 ALQGLDIPPP TGPVWVLGAT FIRKFYTEFD RHNNRIGFAL AR 402 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | REN | 403838 | Q6DYE7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | REN | A0A452ERZ4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | REN | 5972 | P00797 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Ren1 | 19701 | P06281 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | REN | 469651 | H2R877 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | REN | A0A287APG1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ren1 | 24715 | P08424 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ren | Q6XQJ0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0045177 | apical part of cell |
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0004190 | aspartic-type endopeptidase activity |
| GO:0004175 | endopeptidase activity |
| GO:0005159 | insulin-like growth factor receptor binding |
| GO:0008233 | peptidase activity |
| GO:0005102 | signaling receptor binding |
| GO:0050435 | amyloid-beta metabolic process |
| GO:0002003 | angiotensin maturation |
| GO:0048469 | cell maturation |
| GO:0035690 | cellular response to drug |
| GO:0042756 | drinking behavior |
| GO:0009755 | hormone-mediated signaling pathway |
| GO:0001822 | kidney development |
| GO:0008584 | male gonad development |
| GO:0001823 | mesonephros development |
| GO:0006508 | proteolysis |
| GO:0008217 | regulation of blood pressure |
| GO:0002016 | regulation of blood volume by renin-angiotensin |
| GO:0043408 | regulation of MAPK cascade |
| GO:0002018 | renin-angiotensin regulation of aldosterone production |
| GO:0051591 | response to cAMP |
| GO:0070305 | response to cGMP |
| GO:0042493 | response to drug |
| GO:0035902 | response to immobilization stress |
| GO:0032496 | response to lipopolysaccharide |
| GO:0010033 | response to organic substance |
| Pfam ID | Pfam Term |
|---|---|
| PF00026 | Asp |