Gene: REN

Basic information

Tag Content
Uniprot ID A0A452ERZ4
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000014875
Ensembl nucleotide ID ENSCHIG00000015702
Gene name Peptidase A1 domain-containing protein
Gene symbol REN
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
WGTLLLFLTP SWARIFLKKM PSVRESLKER GVDMAQLGAE WSQLTKTLSF GNRTSPVVLT 60
NYLDTQYYGE IGIGTPPQTF KVIFDTGSAN LWVPSTKCSP LYTACEIHSL YDSLESSSYV 120
ENGTEFTIYY GSGNVKGFLS QDLVTVGGIT VTQTFGEVTE LPLRPFMLAK FDGVLGMGFP 180
AQAVGGVTPV FDHILAQRVL TEDVFSVYYS RWAGNSHLLG GEIVLGGSDP QYYQENFHYV 240
SISKPGSWQI RMKGVSVRST TLLCEEGCMV VVDTGASYIS GPTSSLRLLM EALGAKELSI 300
DEYVVNCNQM PTLPDISFHL GGKAYTLTSA DYVLQDPYNN DDLCTLALHG MDIPPPTGPV 360
WVLGATFIRK FYTEFDRRNN RIGFALAR 388

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologREN403838Q6DYE7Canis lupus familiarisPredictionMore>>
1:1 orthologRENA0A452ERZ4Capra hircusPredictionMore>>
1:1 orthologREN5972P00797Homo sapiensPublicationMore>>
1:1 orthologRen119701P06281Mus musculusPredictionMore>>
1:1 orthologREN469651H2R877Pan troglodytesPredictionMore>>
1:1 orthologRENA0A287APG1Sus scrofaPredictionMore>>
1:1 orthologRen124715P08424Rattus norvegicusPredictionMore>>
1:1 orthologrenQ6XQJ0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0004190 aspartic-type endopeptidase activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0064 Aspartyl protease
KW-1015 Disulfide bond
KW-0378 Hydrolase
KW-0645 Protease
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR034135 Renin-like_dom

PROSITE

PROSITE ID PROSITE Term
PS00141 ASP_PROTEASE
PS51767 PEPTIDASE_A1

Pfam

Pfam ID Pfam Term
PF07966 A1_Propeptide
PF00026 Asp