| Tag | Content |
|---|---|
| Uniprot ID | Q6DYE7 |
| Entrez ID | 403838 |
| Genbank protein ID | AAT68959.1 |
| Genbank nucleotide ID | NM_001003194.2 |
| Ensembl protein ID | ENSCAFP00040022078; ENSCAFP00030019403; ENSCAFP00000014146; |
| Ensembl nucleotide ID | ENSCAFG00040013534; ENSCAFG00030011832; ENSCAFG00000009623; |
| Gene name | Renin |
| Gene symbol | REN |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Sequence | MARCRMPRWG LLLVLWGSCT FGLPADTGAF RRIFLKKMPS IRESLKERGV DVAGLGAEWN 60 QFTKRLSSGN STSPVVLTNY LDTQYYGEIG IGTPPQTFKV VFDTGSANLW VPSTRCSPLY 120 TACEIHCLYD SSESSSYMEN GTTFTIRYGS GKVKGFLSQD MVTVGGITVT QTFGEVTELP 180 LIPFMLAKFD GVLGMGFPAQ AVGGVTPVFD HILSQGVLKE EVFSVYYSRN SHLLGGEVVL 240 GGSDPQYYQG NFHYVSISKT GSWQIKMKGV SVRSATLVCE EGCMVVVDTG ASYISGPTSS 300 LRLLMDTLGA QELSTNEYVV NCNQVPTLPD ISFHLGGRAY TLTSKDYVLQ DPYGNEDLCT 360 LALHGLDVPP PTGPVWVLGA SFIRKFYTEF DRHNNRIGFA LAR 403 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | REN | 403838 | Q6DYE7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | REN | A0A452ERZ4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | REN | 5972 | P00797 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Ren1 | 19701 | P06281 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | REN | 469651 | H2R877 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | REN | A0A287APG1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ren1 | 24715 | P08424 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ren | Q6XQJ0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0004190 | aspartic-type endopeptidase activity |
| GO:0002003 | angiotensin maturation |
| GO:0006508 | proteolysis |