| Tag | Content |
|---|---|
| Uniprot ID | A0A287BRK5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000059139 |
| Ensembl nucleotide ID | ENSSSCG00000001832 |
| Gene name | Aggrecan core protein |
| Gene symbol | ACAN |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTTLLLVFVT LRVIAAAISV EVSEPDNSLS VSIPQPSPLR VLLGGSLTIP CYFIDPMHPV 60 TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGQVRVNSAY QDRVTLPNYP AIPSDATLEI 120 QNLRSNDSGI YRCEVMHGIE DSEATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA 180 IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 240 TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG 300 WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPEN 360 FFGVGGEEDI TIQTVTWPDV ELPLPRNITE GEARGTVILT VKPVFEFSPT APEPEEPFTF 420 APGTGATAFP EAENRTGEAT RPWAFPEEST PGLGAPTAFT SEDLVVQVTM APGATEFPGQ 480 PRLPGGVVFH YRPGSSRYSL TFEEAQQACL RTGAVIASPE QLQAAYEAGY EQCDAGWLQD 540 QTVRYPIVSP RTPCVGDKDS TPGVRTYGVR PPSETYDVYC YVDRLEGEVF FATRLEQFTF 600 REAQEFCESQ NATLASTGQL YAAWSRGLDK CYAGWLADGS LRYPIVTPRP ACGGDKPGVR 660 TVYLYPNQTG LLDPLSRHHA FCFRGVSAVA PSPGEEEGGT PTSLPDLEER IATQVGPGVA 720 AVPVGEETTE VAAFTTEPEN RTEWEFVYTP VGTSPLPGIP PTWPPTSAAT EEGTEGPSAT 780 EAPSTSEEPF PSEKPFPSEE PFPSEEPFPS EKPSASEEPF PSEQPSTLSA PVPSRTELPG 840 SGEVSGAPEV SGDFTGSGEV SGHLDYSGQP SGEIASGLPS EDLDSSGLTS AVGSGLPVES 900 GLASGDEDKI TWSSTSKVDR LPSGGEGPEG SVSGVEDLSG LPSGEGPEIS ASGVEDLSRL 960 PSGEGPEISA SGVEDLSRLP SGEGPEISAS GIEDISQLPS GEGPEISASG IEDLSRLPSG 1020 EGPEISASGV EDLSRLPSGE GPEISASGVE DISQLPSGEG PEISASGVED LSRLPSGEGP 1080 EISASGVEDI SQLPSGEGPE ISASGVEDLS RLPSGEGPEI SASGVEDLSR LPSGEGPEIS 1140 ASGVEDISQL PSGEGPEISA SGVEDLSRLP SGEGPEISAS GVEDISQLPS GEGPEISVSG 1200 VEDLSRLPSG EGPEISASGV EDLSRLPSGE GPEISASGVE DISQLPSGEG PEISASGVED 1260 LSRLPSGEGP EISASGVEDL SRLPSGEGPD ISASGVEDLS RLPSGEGPEI SASGIEDLSR 1320 LPSGEGPEIS ASGVEDLSRL PSGEGPEISA SGVEDISQLP SGEGPEISAS GVEDLSRLPS 1380 GEGPEISASG VEDISQLPSG EGPEISASGV EDLSRLPSGE GPEISASGVE DISQLPSGEG 1440 PEISASGVED LSRLPSGGEG HLETSASGVE DLSGIPSGGE DHLESSASGV GDLSGLPSGR 1500 EGLEIYASGA EDLSGLTSGK EDLAGSASGD LDVGRMPSGT LESGQAPEVS GLPSGFSGEY 1560 SGVDLGSGPS SGLPDFSELP SGFPTVSLVD TTLVEMVTAT TASELEGRGT IGVSGAGETF 1620 GLPFSELDIS GGASGHPSGA ELSGQASGSP DISGETSGLF DVSGQPSGFP DISGGTSGLF 1680 EVSGQPSGFS GATSGVTELS GLSSGQPDIS GDASGVLSGV GQPFGLTDVS GETSGVPDLS 1740 GQPSGWPGFS GMPSGTPDLV SSATSGSGES SGITFVDTSL VEVTPTTRKE EEGLGSVELS 1800 GLPSGEADLS GASGVVDVSG LASGATDSSG FTSQPPEFSG LPSGVTEVSG ESSGVEIGSS 1860 LPSGAYDGSG LPLSAPTVYL VDRTLVESVT QAPTAQEAGE GPPGTLELSG AHSGVPDMSG 1920 DHSGSVDLSG LQSGLAEPSG EPASTPYFSG DFSVTTDISG DSSAATSTSG EASGLPEVTL 1980 IASEFVEGVT EPTVSQELGQ RPPVTHTPQL FESSGEASAS GDVPRFPGSG VEAPPIPESS 2040 RESSAYPEAE TGASAAPEAS GGASGSPDLT EATSAFHEAD LEGTSGLGVS VSTSAFQEGT 2100 REVSAAPEVS RESTTTYDVG PEASGLPLAT PVSSGDRTEV SGDLSGHTSG LEVAISTAIP 2160 EYAWTQQTQR PAEAPLEIES SSPVHSGEEM PTAKPATSQT EASIPTPPGQ TDESEATTAD 2220 FDECLSSPCL NGATCVDAID SFTCLCLPSY QGDLCEIGTA VSASANVTNC CTPFSSLTLP 2280 C 2281 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACAN | F1N368 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 403828 | A0A5F4DFW2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACAN | A0A452FGP3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 176 | P16112 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acan | 11595 | Q61282 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACAN | A0A2I3SPH2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACAN | A0A287BRK5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 100009079 | G1U677 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acan | D4A7Y1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005509 | calcium ion binding |
| GO:0005540 | hyaluronic acid binding |
| GO:0007155 | cell adhesion |
| InterPro ID | InterPro Term |
|---|---|
| IPR016186 | C-type_lectin-like/link_sf |
| IPR016187 | CTDL_fold |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003006 | Ig/MHC_CS |
| IPR003599 | Ig_sub |
| IPR013106 | Ig_V-set |
| IPR000538 | Link_dom |