| Tag | Content |
|---|---|
| Uniprot ID | D4A7Y1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000042691 |
| Ensembl nucleotide ID | ENSRNOG00000028992 |
| Gene name | Aggrecan core protein |
| Gene symbol | Acan |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTTLLLVFVT LRVIAAVISE EVPDHDNSLS VSIPQPSPLK ALLGTSLTIP CYFIDPMHPV 60 TTAPSTAPLT PRIKWSRVSK EKEVVLLVAT EGQVRVNSIY QDKVSLPNYP AIPSDATLEI 120 QNLRSNDSGI YRCEVMHGIE DSEATLEVIV KGIVFHYRAI STRYTLDFDR AQRACLQNSA 180 IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 240 TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG 300 WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPEN 360 FFGVGGEEDI TIQTVTWPDL ELPLPRNITE GEARGNVILT AKPIFDMSPT VSEPGEALTL 420 APEVGTTVFP EAGERTEKTT RPWGFPEEAT RGPDSATAFA SEDLVVRVTI SPGAVEVPGQ 480 PRLPGGVVFH YRPGSTRYSL TFEEAQQACI RTGAAIASPE QLQAXYXAGY EQCDAGWLXX 540 XTVXYPIVSP RTPCVGDKDS SPGVRTYGVR PSSETYDVYC YVDKLEGEVF FATQMEQFTF 600 QEAQAFCAAQ NATLASTGQL YAAWSQGLDK CYAGWLADGT LRYPIVNPRP ACGGDKPGVR 660 TVYLYPNQTG LPDPLSKHHA FCFRGVSVAP SPGGTPTSPS DIEDWIVTRV EPGVDAVPLE 720 PETTEVPYFT TEPEKQTEWE PAYTPVGTSP LPGIPPTWLP TVPAAEEHTE SPSASQEPSA 780 SQVPSTSEEP YTPSLAVPSG TELPSSGDTS GAPDLSGDFT GSTDTSGRLD SSGEPSGGSE 840 SGLPSGDLDS SGLGPTVSSG LPVESGSASG DGEIPWSSTP TVGRLPSGGE SLEGSASASG 900 TGDLSGLPSG GEITETSASG TEEISGLPSG GDDLETSTSG IDGASVLPTG RGGLETSASG 960 VEDLSGLPSG EEGSETSTSG IEDISVLPTG ESPETSASGV GDLSGLPSGG ESLETSASGV 1020 EDVTQLPTER GGLETSASGI EDITVLPTGR ENLETSASGV EDVSGLPSGK EGLETSASGI 1080 EDISVFPTEA EGLETSASGG YVSGIPSGED GTETSTSGVE GVSGLPSGGE GLETSASGVE 1140 DLGLPTRDSL ETSASGVDVT GYPSGREDTE TSVPGVGDDL SGLPSGQEGL ETSASGAEDL 1200 GGLPSGKEDL VGSASGALDF GKLPSGTLGS GQTPEASGLP SGFSGEYSGV DIGSGPSSGL 1260 PDFSGLPSGF PTVSLVDSTL VEVITATTAS ELEGRGTISV SGSGEESGPP LSELDSSADI 1320 SGLPSGTELS GQTSGSLDVS GETSGFFDVS GQPFGSSGTG EGTSGIPEVS GQPSGSPDTT 1380 EISELSGLSS GQPDVSGEGS GILFGSGQSS GITSVSGETS GISDLSGQPS GFPVLSGTTP 1440 GTPDLASGAM SGSGDSSGIT FVDTSLIEVT PTTFREEEGL GSVELSGLPS GETDLSGTSG 1500 MVDVSGQSSG AIDSSGLISP TPEFSGLPSG VAEVSGEVSG VETGSSLSSG AFDGSGLVSG 1560 FPTVSLVDRT LVESITLAPT AQEAGEGPSS ILEFSGAHSG TPDISGDLSG SLDQSTWQPG 1620 WTEASTEPPS SPYFSGDFSS TTDASGESIT APTGSGETSG LPEVTLITSE LVEGVTEPTV 1680 SQELGHGPSM TYTPRLFEAS GEASASGDLG GPVTIFPGSG VEASVPEGSS DPSAYPEAGV 1740 GVSAAPEASS QLSEFPDLHG ITSASRETDL EMTTPGTEVS SNPWTFQEGT REGSAAPEVS 1800 GESSTTSDID AGTSGVPFAT PMTSGDRTEI SGEWSDHTSE VNVTVSTTVP ESRWAQSTQH 1860 PTETLQEIGS PNPSYSGEET QTAETAKSLT DTPTLASPEG SGETESTAAD IDECLSSPCL 1920 NGATCVDALD TFTCLCLPSY RGDLCEIDQE QCEEGWTKFQ GHCYRHFPDR ETWVDAERRC 1980 REQQSHLSSI VTPEEQEFVN KNAQDYQWIG LNDRTIEGDF RWSDGHSLQF EKWRPNQPDN 2040 FFATGEDCVV MIWHERGEWN DVPCNYQLPF TCKKGTVACG EPPAVEHART LGQKKDRYEI 2100 SSLVRYQCTE GFVQRHVPTI RCQPSGHWEE PRITCTDPNT YKHRLQKRSM RPTRRSRPSM 2160 AH 2162 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACAN | F1N368 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 403828 | A0A5F4DFW2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACAN | A0A452FGP3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 176 | P16112 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acan | 11595 | Q61282 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACAN | A0A2I3SPH2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACAN | A0A287BRK5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 100009079 | G1U677 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acan | D4A7Y1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0098982 | GABA-ergic synapse |
| GO:0098978 | glutamatergic synapse |
| GO:0098966 | perisynaptic extracellular matrix |
| GO:0005509 | calcium ion binding |
| GO:0005540 | hyaluronic acid binding |
| GO:0001502 | cartilage condensation |
| GO:0007155 | cell adhesion |
| GO:0002063 | chondrocyte development |
| GO:0030199 | collagen fibril organization |
| GO:0007507 | heart development |
| GO:0030166 | proteoglycan biosynthetic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR001304 | C-type_lectin-like |
| IPR016186 | C-type_lectin-like/link_sf |
| IPR018378 | C-type_lectin_CS |
| IPR033987 | CSPG_CTLD |
| IPR016187 | CTDL_fold |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003006 | Ig/MHC_CS |
| IPR003599 | Ig_sub |
| IPR013106 | Ig_V-set |
| IPR000538 | Link_dom |
| IPR035976 | Sushi/SCR/CCP_sf |
| IPR000436 | Sushi_SCR_CCP_dom |