| Tag | Content |
|---|---|
| Uniprot ID | G1U677 |
| Entrez ID | 100009079 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_008251721.2 |
| Ensembl protein ID | ENSOCUP00000024918 |
| Ensembl nucleotide ID | ENSOCUG00000022093 |
| Gene name | Aggrecan core protein |
| Gene symbol | ACAN |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTTLLLVLVA LRVIAAAISG DVSDLDNALS VSIPQPSPVR ALLGTSLTIP CYFIDPVHPV 60 TTAPSTAPLT PRIKWSRISK DKEVVLLVAN EGRVRINSAY QDKVSLPNYP AIPSDATLEI 120 QSLRSNDSGI YRCEVMHGLE DSEATLEVVV KGVVFHYRAI STRYTLDFDR AQRACLQNSA 180 IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 240 TYDVYCFAEE MEGEVFYATS PEKFTFQEAA SECRRLGARL ATTGQLYLAW QAGMDMCSAG 300 WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT GEDFMDIPEN 360 FFGVGGEEDI TVQTVTWPDV ELPVPRNITE GEARGSVVLT AKPVLDVSPT APQPEETFAP 420 GVGATAFPGV ENGTEEATRP RGFADEATLG PSSATAFTSA DLVVQVTAAP GVAEVPGQPR 480 LPGGVVFHYR PGPTRYSLTF EEAQQACLRT GAAMASAEQL QAAYEAGYEQ CDAGWLQDQT 540 VRYPIVSPRT PCVGDKDSSP GVRTYGVRPP SETYDVYCYV DRLEGEVFFA TRLEQFTFQE 600 ALEFCESHNA TLASTGQLYA AWSRGLDRCY AGWLADGSLR YPIVTPRPAC GGDKPGVRTV 660 YLYPNQTGLP DPLSRHHAFC FRGTSEAPSP GPEEGGTATP ASGLEDWIVT QVGPGVAATP 720 RAEERTAVPS FATEPGNQTG WEAASSPVGT SLLPGIPPTW PPTGTAAEGT TEGLSTAAMP 780 SASEGPYTPS SLVARETELP GLGVTSVPPD ISGDLTSSGE ASGLFGPTGQ PLGGSASGLP 840 SGELDSGSLT PTVGSGLPIG SGLASGDEDR IQWSSSTEVG GVTSGAEIPE TSASGVGTDL 900 SGLPSGAEIP ETFASGVGTD LSGLPSGAEI PETFASGVGT DLSGLPSGAE ILETSASGVG 960 TDLSGLPSGA EILETSASGV GTDLSGLPSG AEILETSASG VGTDLSGLPS GAEIPETFAS 1020 GVGTDLSGLP SGAEILETSA SGVGTDLSGL PSGAEIPETS ASGVGTDLSG LPSGAEILET 1080 SASGVGTDLS GLPSGAEILE TSASGVGTDL SGLPSGAEIL ETSASGVGTD LSGLPSGAEI 1140 LETSASGVGT DLSGLPSGAE ILETSASGVG TDLSGLPSGG EIPETFASGV GDLSGLPPGR 1200 EDLETLTSGV GDLSGLSSGK DGLVGSASGA LDFGGTLGSG QIPETSGLPS GYSGEYSEVD 1260 LGSGPSSGLP DFSGLPSGFP TVSLVDTPLV EVVTATTARE LEGRGTIGIS GAGEISGLPS 1320 SELDVSGGTS GADISGEADV GGEASGLIVR GQPSGFPDTS GEAFGVTEVS GLSSGQPDLS 1380 GEASGVLFGS GPPFGITDLS GEPSGQPSGL PEFSGTTHRI PDLVSGATSG SGESSGIAFV 1440 DTSVVEVTPT TLREEEGLGS VEFSGFPSGE TGLSGTPETI DVSGQSSGTI DSSGFTSLAP 1500 EVSGSPSGVA EVSGEASGTE ITSGLPSGVF DSSGLPSGFP TVSLVDRTLV ESVTQAPTAQ 1560 EAEGPSDILE LSGVHSGLPD VSGAHSGFLD PSGLQSGLVE PSGEPPRTPY FSGDFPSTPD 1620 VSGEASAATS SSGDISGLPE VTLVTSEFME GVTRPTVSQE LGQGPPMTHV PKLFESSGEA 1680 LASGDTSGAA PAFPGSGLEA SSVPESHGET SAYAEPGTKA AAAPDASGEA SGSPDSGEIT 1740 SVFREAAGEG ASGLEVSSSS LASQQGPREG SASPEVSGES TTSYEIGTET SGLPLATPAA 1800 SEDRAEVSGD LSGRTPVPVD VVTNVPEAEW IQHSQRPAEM WPETKSSSPS YSGEDTAGTA 1860 ASPASADTPG EPGPTTAAPR SCAEEPCGPG TCQETEGRVT CLCPPGHTGE YCDIDIDECL 1920 SSPCVNGATC VDASDSFTCL CLPSYGGDLC ETDQEVCEEG WTKFQGHCYR HFPDRETWVD 1980 AEGRCREQQS HLSSIVTPEE QEFVNNNAQD YQWIGLNDRT IEGDFRWSDG HPLQFENWRP 2040 NQPDNFFATG EDCVVMIWHE KGEWNDVPCN YHLPFTCKKG TVACGDPPVV EHARTFGQKK 2100 DRYEINSLVR YQCAEGFTQR HVPTIRCQPS GHWEEPRITC THPTTYKRRV QKRSSRTLQR 2160 SQASSAP 2167 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACAN | F1N368 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 403828 | A0A5F4DFW2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACAN | A0A452FGP3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 176 | P16112 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acan | 11595 | Q61282 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACAN | A0A2I3SPH2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACAN | A0A287BRK5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 100009079 | G1U677 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acan | D4A7Y1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005509 | calcium ion binding |
| GO:0005540 | hyaluronic acid binding |
| GO:0007155 | cell adhesion |
| InterPro ID | InterPro Term |
|---|---|
| IPR001304 | C-type_lectin-like |
| IPR016186 | C-type_lectin-like/link_sf |
| IPR018378 | C-type_lectin_CS |
| IPR033987 | CSPG_CTLD |
| IPR016187 | CTDL_fold |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003006 | Ig/MHC_CS |
| IPR003599 | Ig_sub |
| IPR013106 | Ig_V-set |
| IPR000538 | Link_dom |
| IPR035976 | Sushi/SCR/CCP_sf |
| IPR000436 | Sushi_SCR_CCP_dom |