Gene: ACAN

Basic information

Tag Content
Uniprot ID A0A452FGP3
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000023523
Ensembl nucleotide ID ENSCHIG00000021027
Gene name Uncharacterized protein
Gene symbol ACAN
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTTLLLVFVT LRVIAAAISV EVSEPDNSLS VSIPEPSPLR VLLGSSLTIP CYFIDPMHPV 60
TTAPSTAPLA PRIKWSRISK EKEVVLLVAT EGRVRVNSAY QDKVTLPNYP AIPSDATLEI 120
QNLRSNDSGI YRCEVMHGIE DSQATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA 180
IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 240
TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG 300
WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPEN 360
FFGVGGEEDI TIQTVTWPDV ELPLPRNITE GEARGNVILT AKPDFEVSPT APEREEPFTF 420
APEVRATAFP AVENRTGEAT WPWAFPREST PGVGAPTAFT SEDLVVQVTL APGVTEVPGQ 480
PRLPGGVVFH YRPGSSRYSL TFEEAKEACL RTGAVIASPE QLQAAYEAGY EQCDAGWLQD 540
QTVRYPIVSP RTPCVGDKDS SPGVRTYGLR PPSETYDVYC YVDRLEGEVF FATRLEQFTF 600
REAQEFCESQ NATLATTGQL YAAWSRGLDK CYAGWLSDGS LRYPIVTPRP ACGGDKPGVR 660
TVYLYPNQTG LLDPLSRHHA FCFRGVSAAP SPGEEEGSTP TAGPEVEDWI VTEVRPGVAA 720
VPVGEETTAI PGFTVEPENK TEWELAYTPA GTFPLPGIPP TWPPTGEATE EHTEGPSATE 780
VPSASEKPFP SEEPFLPEEP FPSEKPFPPE ELFPSEKPFP SEKPFPSEKP FPSEEPFPSE 840
KPFPPEELFP SEKPIPSEEP FPSEKPFPPE EPFPSEKPIP SEEPFPSEKP FPPEEPFPSE 900
KPIPSEEPFP SEEPSTLSAP VPSRTELPTS GEASGVPEVS GDFTGSGEIS GHLDFSGQPS 960
GESASGLPSE DFDSSGLTPT VGSGLPVESG LPSGEEERIT WTSAPKVDRL PSRGEGPEVS 1020
ASGVEDISGL PSGGEVHLEI SASGVEDLSG LPSGEEGHLE ISASGVEDLS GIPSGEGPEV 1080
SVSGVEDLSR LPSGEGPEVS ASGVEDLSRL PSGEGPEVSA SGVEDLGVLP SGEGPEVSAS 1140
GVEDLSRFPS GEGPEVSASG VEDLGVLPSG EGHLEISASG VEDLSRLPSG EGPEVSASGV 1200
EDLGVLPSGE GHLEISASGV EDLGVLPSGE GHLEISASGV EDLSRLPSGE GPEVSASGVE 1260
DLGVLPSGEG HLEISASGVE DLSVLPSGEG HLEISASGVE DLSRLPSGEG HLEISASGVE 1320
DLGVLPSGEG HLEISASGVE DLSVLPSGEG HLEISASGVE DLSRLPSGEG HLEISASGVE 1380
DLGVLPSGEG HLEISASGVE DLSRLPSGGE EHLETSASGV GDLSGLPSGR EGLEISASGA 1440
GDLSGLTSGK EDLTGSASGA LDLGRIPSVT LGSGQAPEAS GLPSGFSGEY SGVDLGSGPS 1500
SGLPDLSGLP SGFPTVSLVD TTLVEVVTAT TAGELEGRGT IDISGAGETS GLPFSELDIS 1560
GEASGLSSGA ELSGQASGSP EISGETSGLF GVSGQPSGFP DISGETSGLL EVSGQPSGFS 1620
GEISGVTELS GLPSGQPEIS GEASGILSGL GPPFGITDLS GEAPGIPDLS GQPSGLPEFS 1680
GTTSGIPDLV SSAVSGSGES SGIMFVDTSL VEVTPTTFKE EEGLGSVELS GLPSGEAGLS 1740
GTSGLVDVSG LSSGAIDSSG FTPQPPEFSG LPSGVTEVSG EASGAASGSS LPSGAYDSSG 1800
LPSGFPTVSF VDRTLVESVT QAPTAQEAGE GPSGILELSG TPSGAPDMSG DHLGSLDQSG 1860
LQSGLVEPRG EPASTPYFSG DFSGATDVSG ESSAATSTSG EASGLPEVTL ITSELVEGVT 1920
EPTVSQELGQ RPPITYTPQL FESSGEASVS GDVPRFPGSG VEASPVPESS GETSAYPEAE 1980
VGASAAPEAR GGASGSPNLS ETTSTFHEAD LEGTSGLGAS GSPSAFPEGP TEGLATPEVS 2040
GESTTAFDVS VEASGSPSAT PLASGDRTDT SGDLSGHTSG LDIVISTTIP ESEWTQQTQR 2100
PAEARLEIES SSPVHSGEET QTADTATSST DASIPTSTGG TDDSEATTTD QKLCEEGWTK 2160
FQGHCYRHFP DRATWVDAES QCRKQQSHLS SIVTPEEQEF VNNNAQDYQW IGLNDKTIEG 2220
DFRWSDGHSL QFENWRPNQP DNFFATGEDC VVMIWHEKGE WNDVPCNYQL PFTCKKGTVA 2280
CGEPPVVEHA RIFGQKKDRY EINALVRYQC TEGFIQRHVP TIRCQPSGHW EEPRITCTDP 2340
ATYKRRLQKR SSRPLRRSRP STAH 2364

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologACANF1N368Bos taurusPredictionMore>>
1:1 orthologACAN403828A0A5F4DFW2Canis lupus familiarisPredictionMore>>
1:1 orthologACANA0A452FGP3Capra hircusPredictionMore>>
1:1 orthologACAN176P16112Homo sapiensPredictionMore>>
1:1 orthologAcan11595Q61282CPOMus musculusPublicationMore>>
1:1 orthologACANA0A2I3SPH2Pan troglodytesPredictionMore>>
1:1 orthologACANA0A287BRK5Sus scrofaPredictionMore>>
1:1 orthologACAN100009079G1U677Oryctolagus cuniculusPredictionMore>>
1:1 orthologAcanD4A7Y1Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005540 hyaluronic acid binding
GO:0007155 cell adhesion

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0393 Immunoglobulin domain
KW-1185 Reference proteome
KW-0732 Signal
KW-0768 Sushi

Interpro

InterPro ID InterPro Term
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

PROSITE

PROSITE ID PROSITE Term
PS00615 C_TYPE_LECTIN_1
PS50041 C_TYPE_LECTIN_2
PS50835 IG_LIKE
PS00290 IG_MHC
PS01241 LINK_1
PS50963 LINK_2
PS50923 SUSHI

Pfam

Pfam ID Pfam Term
PF00059 Lectin_C
PF00084 Sushi
PF07686 V-set
PF00193 Xlink