| Tag | Content |
|---|---|
| Uniprot ID | F1N368 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005221803.3 |
| Ensembl protein ID | ENSBTAP00000021512 |
| Ensembl nucleotide ID | ENSBTAG00000016158 |
| Gene name | Aggrecan core protein |
| Gene symbol | ACAN |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTTLLLVFVT LRVITAAISV EVSEPDNSLS VSIPEPSPLR VLLGSSLTIP CYFIDPMHPV 60 TTAPSTAPLA PRIKWSRISK EKEVVLLVAT EGRVRVNSAY QDKVTLPNYP AIPSDATLEI 120 QNMRSNDSGI YRCEVMHGIE DSQATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA 180 IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 240 TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG 300 WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPES 360 FFGVGGEEDI TIQTVTWPDV ELPLPRNITE GEARGSVILT AKPDFEVSPT APEPEEPFTF 420 VPEVRATAFP EVENRTEEAT RPWAFPREST PGLGAPTAFT SEDLVVQVTL APGAAEVPGQ 480 PRLPGGVVFH YRPGSSRYSL TFEEAKQACL RTGAIIASPE QLQAAYEAGY EQCDAGWLQD 540 QTVRYPIVSP RTPCVGDKDS SPGVRTYGVR PPSETYDVYC YVDRLEGEVF FATRLEQFTF 600 WEAQEFCESQ NATLATTGQL YAAWSRGLDK CYAGWLADGS LRYPIVTPRP ACGGDKPGVR 660 TVYLYPNQTG LLDPLSRHHA FCFRGVSAAP SPEEEEGSAP TAGPDVEEWM VTQVGPGVAA 720 VPIGEETTAI PGFTVEPENK TEWELAYTPA GTLPLPGIPP TWPPTGEATE EHTEGPSATE 780 VPSASEKPFP SEEPFPPEEP FPSEKPFPPE ELFPSEKPFP SEKPFPSEEP FPSEKPFPPE 840 ELFPSEKPIP SEEPFPSEEP FPSEKPFPPE EPFPSEKPIP SEEPFPSEKP FPSEEPFPSE 900 EPSTLSAPVP SRTELPSSGE VSGVPEISGD FTGSGEISGH LDFSGQPSGE SASGLPSEDL 960 DSSGLTSTVG SGLPVESGLP SGEEERITWT SAPKVDRLPS GGEGPEVSGV EDISGLPSGG 1020 EVHLEISASG VEDISGLPSG GEVHLEISAS GVEDLSRIPS GEGPEISASG VEDISGLPSG 1080 EEGHLEISAS GVEDLSGIPS GEGPEVSASG VEDLIGLPSG EGPEVSASGV EDLSRLPSGE 1140 GPEVSASGVE DLSGLPSGEG PEVSVSGVED LSRLPSGEGP EVSASGVEDL SRLPSGEGPE 1200 ISVSGVEDIS ILPSGEGPEV SASGVEDLSV LPSGEGHLEI STSGVEDLSV LPSGEGHLEI 1260 SASGVEDISR LPSGEGPEVS ASGVEDLSVL PSGEDHLEIS ASGVEDLGVL PSGEDHLEIS 1320 ASGVEDISRL PSGEGPEVSA SGVEDLSVLP SGEGHLEISA SGVEDLSRLP SGGEDHLETS 1380 ASGVGDLSGL PSGREGLEIS ASGAGDLSGL TSGKEDLTGS ASGALDLGRI PSVTLGSGQA 1440 PEASGLPSGF SGEYSGVDLE SGPSSGLPDF SGLPSGFPTV SLVDTTLVEV VTATTAGELE 1500 GRGTIDISGA GETSGLPFSE LDISGGASGL SSGAELSGQA SGSPDISGET SGLFGVSGQP 1560 SGFPDISGET SGLLEVSGQP SGFYGEISGV TELSGLASGQ PEISGEASGI LSGLGPPFGI 1620 TDLSGEAPGI PDLSGQPSGL PEFSGTTSGI PDLVSSAVSG SGESSGITFV DTSLVEVTPT 1680 TFKEEEGLGS VELSGLPSGE VGVSGTSGLA DVSGLSSGAI DSSGFTSQPP EFSGLPSGVT 1740 EVSGEASGAE SGSSLPSGAY DSSGLPSGFP TVSFVDRTLV ESVTQAPTAQ EAGEGPSGIL 1800 ELSGAPSGAP DMSGDHLGSL DQSGLQSGLV EPSGEPASTP YFSGDFSGTT DVSGESSAAT 1860 STSGEASGLP EVTLITSELV EGVTEPTVSQ ELGQRPPVTY TPQLFESSGE ASASGDVPRF 1920 PGSGVEVSSV PESSGETSAY PEAEVGASAA PEASGGASGS PNLSETTSTF HEADLEGTSG 1980 LGVSGSPSAF PEGPTEGLAT PEVSGESTTA FDVSVEASGS PSATPLASGD RTDTSGDLSG 2040 HTSGLDIVIS TTIPESEWTQ QTQRPAEARL EIESSSPVHS GEESQTADTA TSPTDASIPA 2100 SAGGTDDSEA TTTDIDECLS SPCLNGATCV DAIDSFTCLC LPSYQGDVCE IDQKLCEEGW 2160 TKFQGHCYRH FPDRATWVDA ESQCRKQQSH LSSIVTPEEQ EFVNNNAQDY QWIGLNDKTI 2220 EGDFRWSDGH SLQFENWRPN QPDNFFATGE DCVVMIWHEK GEWNDVPCNY QLPFTCKKGT 2280 VACGEPPVVE HARIFGQKKD RYEINALVRY QCTEGFIQRH VPTIRCQPSG HWEEPRITCT 2340 DPATYKRRLQ KRSSRPLRRS HPSTAH 2366 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACAN | F1N368 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 403828 | A0A5F4DFW2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACAN | A0A452FGP3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 176 | P16112 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acan | 11595 | Q61282 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACAN | A0A2I3SPH2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACAN | A0A287BRK5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 100009079 | G1U677 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acan | D4A7Y1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0031012 | extracellular matrix |
| GO:0098982 | GABA-ergic synapse |
| GO:0098978 | glutamatergic synapse |
| GO:0098966 | perisynaptic extracellular matrix |
| GO:0005509 | calcium ion binding |
| GO:0005540 | hyaluronic acid binding |
| GO:0001502 | cartilage condensation |
| GO:0007155 | cell adhesion |
| GO:0007417 | central nervous system development |
| GO:0002063 | chondrocyte development |
| GO:0030199 | collagen fibril organization |
| GO:0007507 | heart development |
| GO:0030166 | proteoglycan biosynthetic process |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR001304 | C-type_lectin-like |
| IPR016186 | C-type_lectin-like/link_sf |
| IPR018378 | C-type_lectin_CS |
| IPR033987 | CSPG_CTLD |
| IPR016187 | CTDL_fold |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003006 | Ig/MHC_CS |
| IPR003599 | Ig_sub |
| IPR013106 | Ig_V-set |
| IPR000538 | Link_dom |
| IPR035976 | Sushi/SCR/CCP_sf |
| IPR000436 | Sushi_SCR_CCP_dom |