| Tag | Content |
|---|---|
| Uniprot ID | A0A5F4DFW2 |
| Entrez ID | 403828 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001113455.2 |
| Ensembl protein ID | ENSCAFP00000065577 |
| Ensembl nucleotide ID | ENSCAFG00000011534 |
| Gene name | Aggrecan core protein |
| Gene symbol | ACAN |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTTLLLVFVT LRVITAASSL EASDPDNSLS VSIPEPSPMR VLLGSSLTIP CYFIDPMHPV 60 TTAPSTAPLA PRIKWSRITK EKEVVLLVAT EGQVRINSAY QDKVSLPNYP AIPSDATLEI 120 QNLRSNDSGI YRCEVMHGIE DSEATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA 180 IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 240 TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG 300 WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPEN 360 FFGVGGEEDI TIQTVTWPDV ELPLPRNITE GEARGNVILT VKPIFDLSPT APEPEEPFTF 420 VPEPEKPFTF ATDVGVTAFP EAENRTGEAT RPWGVPEEST PGPAFTAFTS EDHVVQVTAV 480 PGAAEVPGQP RLPGGVVFHY RPGSARYSLT FEEAQQACLR TGAVIASPEQ LQAAYEAGYE 540 QCDAGWLQDQ TVRYPIVSPR TPCVGDKDSS PGVRTYGVRP PSETYDVYCY VDKLEGEVFF 600 ITRLEQFTFQ EALAFCESHN ATLASTGQLY AAWSQGLDKC YAGWLSDGSL RYPIVTPRPS 660 CGGDKPGVRT VYLYPNQTGL PDPLSRHHAF CFRGVSAVPS PGEEEGGTPT PSVVEDWIAT 720 QVGPGVAAVP MGEETTAILD FTIEPENQTE WEPAYSPAGT SPLPGIPPTW PPTSTATEES 780 TEGPSGTEVP SVSEEPSPSE EPFPWEELST LSPPGPSGTE LPGSGEASGV PEVSGDFTGS 840 GEVSGHPDSS GQLSGESASG LPSEDLDSSG LTSAVGSGLA SGDEDRITLS SIPKVEGEGL 900 ETSASGVEDL SGLPSGREGL ETSTSGVGDL SGLPSGEGLE VSASGVEDLS GLPSGEGPET 960 SASGVGDLSR LPSGEGPEVS ASGVGDLSGL PSGREGLETS TSGVEDLSGL PSGEGPEAST 1020 SGVGDLSRLP SGEGPEVSAS GVEDLSGLPS GEGLEASASG VGDLSGLPSG EGPEASASGV 1080 GDLSRLPSGE GPEVSASGVE DLSGLSSGES PEASASGVGD LSGLPSGREG LETSASGVGD 1140 LSGLPSGEGQ EASASGVEDL SRLPSGEGPE ASASGVGELS GLPSGREGLE TSASGVGDLS 1200 GLPSGEGPEA FASGVEDLSI LPSGEGPEAS ASGVGDLSGL PSGREGLETS TSGVGDLSGL 1260 PSGREGLETS TSGVGDLSGL PSGEGPEASA SGIGDISGLP SGREGLETSS SGVEDHPETS 1320 ASGVEDLSGL PSGVEGHPET SASGVEDLSE LSSGGEGLET SASGAEDLSG LPSGKEDLIG 1380 SASGALDFGR IPSGTLGSGQ APEASSLPSG FSGEYSGVDF GSGPSSGLPD FSGLPSGFPT 1440 ISLVDTTLVE VITTTSASEL EGRGTIGISG AGETSGLPVS ELDISGAVSG LPSGAELSGQ 1500 ASGSPDMSGE TSGFFGVSGQ PSGFPDISGG TSGLFEVSGQ PSGFSGETSG VTELSGLYSG 1560 QPDVSGEASG VPSGSGEPFG MTDLSGETSG VPDISGQPSG LPEFSGTTSG IPDLVSSTMS 1620 GSGESSGITF VDTSLVEVTP TTFKEEEGLG SVELSGLPSG EVDLSGASGT MDISGQSSGA 1680 TDSSGLTSQL PEFSGLPSGA AEVSGESSGA EIGSSLPSGT YEGSGLPSSF PTVSLVDRTL 1740 VESVTQAPTA QEAGEGPSGI LELSGAHSGA PDVSGDHSGS LDLSGMQSGL VEPSGEPSST 1800 PYFSGDFSGT MDVTGEPSTA MSASGEASGL LEVTLITSEF VEGVTEPTVS QELAQRPPVT 1860 HTPQLFESSG EASASGEISG ATPAFPGSGL EASSVPESSS ETSDFPERAV GVSAAPEASG 1920 GASGAPDVSE ATSTFPEANV EGASGLGVSG GTSAFPEGPR EGSATPEVQE EPTTSYDVGR 1980 EALGWPSATP TASGDRIEVS GDLSGHTSGL DVVISTSVPE SEWIQQTQRP AEAHLEIEAS 2040 SPLHSGEETQ TAETATSPTD DASIPTSPSG TDESAPAIPD IDECLSSPCL NGATCVDAID 2100 SFTCLCLPSY RGDLCEIDQE LCEEGWTKFQ GHCYRYFPDR ESWVDAESRC RAQQSHLSSI 2160 VTPEEQEFVN NNAQDYQWIG LNDRTIEGDF RWSDGHSLQF ENWRPNQPDN FFVSGEDCVV 2220 MIWHEKGEWN DVPCNYYLPF TCKKGTVACG DPPVVEHART FGQKKDRYEI NSLVRYQCTE 2280 GFVQRHVPTI RCQPSGHWEK PRITCTDPST YKRRLQKRSS RAPRRSRPST AH 2332 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACAN | F1N368 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 403828 | A0A5F4DFW2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACAN | A0A452FGP3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 176 | P16112 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acan | 11595 | Q61282 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACAN | A0A2I3SPH2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACAN | A0A287BRK5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ACAN | 100009079 | G1U677 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acan | D4A7Y1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005509 | calcium ion binding |
| GO:0005540 | hyaluronic acid binding |
| GO:0007155 | cell adhesion |
| InterPro ID | InterPro Term |
|---|---|
| IPR001304 | C-type_lectin-like |
| IPR016186 | C-type_lectin-like/link_sf |
| IPR018378 | C-type_lectin_CS |
| IPR033987 | CSPG_CTLD |
| IPR016187 | CTDL_fold |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003006 | Ig/MHC_CS |
| IPR003599 | Ig_sub |
| IPR013106 | Ig_V-set |
| IPR000538 | Link_dom |
| IPR035976 | Sushi/SCR/CCP_sf |
| IPR000436 | Sushi_SCR_CCP_dom |