Gene: OPA1

Basic information

Tag Content
Uniprot ID A0A2I3RGT4; A0A2J8M6C3;
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000063870
Ensembl nucleotide ID ENSPTRG00000015752
Gene name OPA1 mitochondrial dynamin like GTPase
Gene symbol OPA1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL QRPQLRTSFQ 60
QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL RYLILGSAVG GGYTAKKTFD 120
QWKDMIPDLS EYKWIVPDIV WEIDEYIDFG SPGETAFRAT DHGSESDKHF RKGLLGELIL 180
LQQQIQEREE EARRAAGQYS TSYAQQKRKV SDKEKIDQLQ EELLHTQLKY QRILERLEKE 240
NKELRKLVLQ KDDKGIHHRK LKKSLIDMYS EVLDVLSDYD ASYNTQDHLP RVVVVGDQSA 300
GKTSVLEMIA QARIFPRGSG EMMTRSPVKV TLSEGPHHVA LFKDSSREFD LTKEEDLAAL 360
RHEIELRMRK NVKEGCTVSP ETISLNVKGP GLQRMVLVDL PGVINTVTSG MAPDTKETIF 420
SISKAYMQNP NAIILCIQDG SVDAERSIVT DLVSQMDPHG RRTIFVLTKV DLAEKNVASP 480
SRIQQIIEGK LFPMKALGYF AVVTGKGNSS ESIEAIREYE EEFFQNSKLL KTSMLKAHQV 540
TTRNLSLAVS DCFWKMVRES VEQQADSFKA TRFNLETEWK NNYPRLRELD RNELFEKAKN 600
EILDEVISLS QVTPKHWEEI LQQSLWERVS THVIENIYLP AAQTMNSGTF NTTVDIKLKQ 660
WTDKQLPNKA VEVAWETLQE EFSRFMTEPK GKEHDDIFDK LKEAVKEESI KRHKWNDFAE 720
DSLRVIQHNA LEDRSISDKQ QWDAAIYFME EALQARLKDT ENAIENMVGP DWKKRWIYWK 780
NRTQEQCVHN ETKNELEKML KCNEEHPAYL ASDEITTVRK NLESRGVEVD PSLIKDTWHQ 840
VYRRHFLKTA LNHCNLCRRG FYYYQRHFVD SELECNDVVL FWRIQRMLAI TANTLRQQLT 900
NTEVRRLEKN VKEVLEDFAE DGEKKIKLLT GKRVQLAEDL KKVREIQEKL DAFIEALHQE 960
K 961

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologOPA1524142A0A3Q1LJL3Bos taurusPredictionMore>>
1:1 orthologOPA1A0A452EKZ3Capra hircusPredictionMore>>
1:1 orthologOPA1100059993F6Z2C8Equus caballusPredictionMore>>
1:1 orthologOPA14976O60313Homo sapiensPredictionMore>>
1:1 orthologOpa174143P58281CPOMus musculusPublicationMore>>
1:1 orthologOPA1A0A2I3RGT4Pan troglodytesPredictionMore>>
1:1 orthologOpa1171116Q2TA68Rattus norvegicusPredictionMore>>
1:1 orthologopa1492332Q5U3A7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005739 mitochondrion
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0342 GTP-binding
KW-0547 Nucleotide-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001401 Dynamin_GTPase
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR033047 Opa1
IPR027417 P-loop_NTPase

PROSITE

PROSITE ID PROSITE Term
PS51718 G_DYNAMIN_2

Pfam

Pfam ID Pfam Term
PF00350 Dynamin_N