Gene: OPA1

Basic information

Tag Content
Uniprot ID A0A452EKZ3
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000012594
Ensembl nucleotide ID ENSCHIG00000014105
Gene name Dynamin-type G domain-containing protein
Gene symbol OPA1
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MWRVRRAAVA CEVCQSLVKH SPGTKGSLPL QKLHLVSRSI YHTHHPTLKL QRPQIRTSLQ 60
QFSSLTSFPL RKLKLSPVKY GYQPHRNFWP ARLAARLLKL RYLILGSAVG GGYTAKKTFD 120
QWKDMIPDLS DYKWIVPDIV WEIDEYIDLE KIRKALPNSE DLAKLAPDFD KIAESLSLLK 180
DFFTTGSPGE TAFRATDPGS ESDKRYRKVS DKEKIDQLQE ELLHTQLKYQ RILERLEKEN 240
KELRKLVLQK DDKGIHHRKL KKSLIDMYSE VLDVLSDYDA SYNTQDHLPR VVVVGDQSAG 300
KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL FKDSSREFDL TKEEDLAALR 360
HEIELRMRKN VKEGCTVSPE TISLNVKGPG LQRMVLVDLP GVINTVTSGM APDTKETIFS 420
ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPHGR RTIFVLTKVD LAEKNVTSPS 480
RVRANSLLVM GFFWVFIKKA NSESIEAIRD YEEEFFQNSK LLKTSMLKAH QVTTRNLSLA 540
VSDCFWKMVR ESVEQQADSF KATRFNLETE WKNNYPRLRE LDRNELFEKA KNEILDEVIS 600
LSQVTPKHWE EILQQSLWER VSTHVIENIY LPAAQTMNSG TFNTTVDIKL KQWTDKQLPN 660
KAVEVAWETL QEEFSRFMTE PKGKEHDDIF DKLKEAVKEE SIKRHKWNDF AEDSLRVIQH 720
NALEDRSISD KQQWDAAIYF MEEALQARLK DTENAIENMV GPDWKKRWLY WKNRTQEQCV 780
HNETKNELEK MLKCNEEHPA YLASDEITTV RKNLESRGVE VDPSLIKDTW HQVYRRHFLK 840
TALNHCNLCR RGFYYYQRHF VDSELECNDV VLFWRIQRML AITANTLRQQ LTNTEVRRLE 900
KNVKEVLEDF AEDSEKKVKL LTGKRVQLAE DLSKIVREID SKTFVSSWFI ILC 953

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologOPA1524142A0A3Q1LJL3Bos taurusPredictionMore>>
1:1 orthologOPA1A0A452EKZ3Capra hircusPredictionMore>>
1:1 orthologOPA1100059993F6Z2C8Equus caballusPredictionMore>>
1:1 orthologOPA14976O60313Homo sapiensPredictionMore>>
1:1 orthologOpa174143P58281CPOMus musculusPublicationMore>>
1:1 orthologOPA1A0A2I3RGT4Pan troglodytesPredictionMore>>
1:1 orthologOpa1171116Q2TA68Rattus norvegicusPredictionMore>>
1:1 orthologopa1492332Q5U3A7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005739 mitochondrion
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0342 GTP-binding
KW-0547 Nucleotide-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001401 Dynamin_GTPase
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR033047 Opa1
IPR027417 P-loop_NTPase

PROSITE

PROSITE ID PROSITE Term
PS51718 G_DYNAMIN_2

Pfam

Pfam ID Pfam Term
PF00350 Dynamin_N