| Tag | Content |
|---|---|
| Uniprot ID | P58281; A6H6Q3; Q3ULA5; Q8BKU7; Q8BLL3; Q8BM08; Q8R3J7; |
| Entrez ID | 74143 |
| Genbank protein ID | BAC26331.1; BAB59000.1; BAC32021.1; BAC30002.1; AAH25160.1; BAC34224.1; AAI45960.1; AAI38666.1; BAE26544.1; |
| Genbank nucleotide ID | NM_133752.3; XM_006522657.2; |
| Ensembl protein ID | ENSMUSP00000124223; ENSMUSP00000123880; |
| Ensembl nucleotide ID | ENSMUSG00000038084 |
| Gene name | Dynamin-like 120 kDa protein, mitochondrial |
| Gene symbol | Opa1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 20652258 |
| Functional description | Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:11847212, PubMed:24616225, PubMed:26785494, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (By similarity). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (PubMed:16839884, PubMed:16839885). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (PubMed:16839884, PubMed:16839885). Plays a role in mitochondrial genome maintenance (By similarity). |
| Sequence | MWRAGRAAVA CEVCQSLVKH SSGIQRNVPL QKLHLVSRSI YRSHHPALKL QRPQLRTPFQ 60 QFSSLTHLSL HKLKLSPIKY GYQPRRNFWP ARLAARLLKL RYIILGSAVG GGYTAKKTFD 120 EWKDMIPDLS DYKWIVPDFI WEIDEYIDLE KIRKALPSSE DLASLAPDLD KITESLSLLK 180 DFFTAGSPGE TAFRATDHGS ESDKHYRKVS DKEKIDQLQE ELLHTQLKYQ RILERLEKEN 240 KELRKLVLQK DDKGIHHRKL KKSLIDMYSE VLDVLSDYDA SYNTQDHLPR VVVVGDQSAG 300 KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL FKDSSREFDL TKEEDLAALR 360 HEIELRMRKN VKEGCTVSPE TISLNVKGPG LQRMVLVDLP GVINTVTSGM APDTKETIFS 420 ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPHGR RTIFVLTKVD LAEKNVASPS 480 RIQQIIEGKL FPMKALGYFA VVTGKGNSSE SIEAIREYEE EFFQNSKLLK TSMLKAHQVT 540 TRNLSLAVSD CFWKMVRESV EQQADSFKAT RFNLETEWKN NYPRLRELDR NELFEKAKNE 600 ILDEVISLSQ VTPKHWEEIL QQSLWERVST HVIENIYLPA AQTMNSGTFN TTVDIKLKQW 660 TDKQLPNKAV EVAWETLQEE FSRFMTEPKG KEHDDIFDKL KEAVKEESIK RHKWNDFAED 720 SLRVIQHNAL EDRSISDKQQ WDAAIYFMEE ALQGRLKDTE NAIENMIGPD WKKRWMYWKN 780 RTQEQCVHNE TKNELEKMLK VNDEHPAYLA SDEITTVRKN LESRGVEVDP SLIKDTWHQV 840 YRRHFLKTAL NHCNLCRRGF YYYQRHFIDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN 900 TEVRRLEKNV KEVLEDFAED GEKKVKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK 960 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | OPA1 | 524142 | A0A3Q1LJL3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | OPA1 | A0A452EKZ3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | OPA1 | 100059993 | F6Z2C8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | OPA1 | 4976 | O60313 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Opa1 | 74143 | P58281 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | OPA1 | A0A2I3RGT4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Opa1 | 171116 | Q2TA68 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | opa1 | 492332 | Q5U3A7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003924 | GTPase activity | ISS |
| GO:0003924 | GTPase activity | ISO |
| GO:0003924 | GTPase activity | TAS |
| GO:0003924 | GTPase activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | IEA |
| GO:0008017 | microtubule binding | IBA |
| GO:0019900 | kinase binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0070300 | phosphatidic acid binding | ISS |
| GO:0070300 | phosphatidic acid binding | ISO |
| GO:1901612 | cardiolipin binding | ISS |
| GO:1901612 | cardiolipin binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000002 | mitochondrial genome maintenance | ISS |
| GO:0000002 | mitochondrial genome maintenance | ISO |
| GO:0000266 | mitochondrial fission | IBA |
| GO:0001843 | neural tube closure | IMP |
| GO:0006915 | apoptotic process | IEA |
| GO:0007005 | mitochondrion organization | ISO |
| GO:0007005 | mitochondrion organization | NAS |
| GO:0007007 | inner mitochondrial membrane organization | ISS |
| GO:0007007 | inner mitochondrial membrane organization | ISO |
| GO:0007601 | visual perception | ISS |
| GO:0007601 | visual perception | ISO |
| GO:0008053 | mitochondrial fusion | ISS |
| GO:0008053 | mitochondrial fusion | ISO |
| GO:0008053 | mitochondrial fusion | IMP |
| GO:0010636 | positive regulation of mitochondrial fusion | ISO |
| GO:0014042 | positive regulation of neuron maturation | ISO |
| GO:0036444 | calcium import into the mitochondrion | ISO |
| GO:0043066 | negative regulation of apoptotic process | ISS |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0046039 | GTP metabolic process | ISS |
| GO:0046039 | GTP metabolic process | ISO |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | ISO |
| GO:0048285 | organelle fission | IBA |
| GO:0048312 | intracellular distribution of mitochondria | ISO |
| GO:0051259 | protein complex oligomerization | ISO |
| GO:0061003 | positive regulation of dendritic spine morphogenesis | ISO |
| GO:0061025 | membrane fusion | IBA |
| GO:0070584 | mitochondrion morphogenesis | ISO |
| GO:0090201 | negative regulation of release of cytochrome c from mitochondria | ISO |
| GO:0090201 | negative regulation of release of cytochrome c from mitochondria | IMP |
| GO:0090398 | cellular senescence | ISO |
| GO:0097749 | membrane tubulation | ISS |
| GO:0097749 | membrane tubulation | ISO |
| GO:1900006 | positive regulation of dendrite development | ISO |
| GO:1900078 | positive regulation of cellular response to insulin stimulus | ISO |
| GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | ISO |
| GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | IMP |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005654 | nucleoplasm | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005739 | mitochondrion | ISO |
| GO:0005739 | mitochondrion | IDA |
| GO:0005739 | mitochondrion | HDA |
| GO:0005739 | mitochondrion | IBA |
| GO:0005741 | mitochondrial outer membrane | ISS |
| GO:0005741 | mitochondrial outer membrane | ISO |
| GO:0005743 | mitochondrial inner membrane | HDA |
| GO:0005743 | mitochondrial inner membrane | IMP |
| GO:0005743 | mitochondrial inner membrane | IDA |
| GO:0005758 | mitochondrial intermembrane space | ISO |
| GO:0005758 | mitochondrial intermembrane space | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0015630 | microtubule cytoskeleton | IBA |
| GO:0016020 | membrane | IBA |
| GO:0016021 | integral component of membrane | IEA |
| GO:0030061 | mitochondrial crista | ISS |
| GO:0030061 | mitochondrial crista | ISO |
| GO:0030425 | dendrite | IDA |
| GO:0031314 | extrinsic component of mitochondrial inner membrane | ISO |
| GO:0031410 | cytoplasmic vesicle | IBA |
| GO:0031966 | mitochondrial membrane | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109581 | Apoptosis | IEA |
| R-MMU-169911 | Regulation of Apoptosis | IEA |
| R-MMU-5357801 | Programmed Cell Death | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0025 | Alternative splicing |
| KW-0053 | Apoptosis |
| KW-0175 | Coiled coil |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0446 | Lipid-binding |
| KW-0472 | Membrane |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0547 | Nucleotide-binding |
| KW-1185 | Reference proteome |
| KW-0716 | Sensory transduction |
| KW-0809 | Transit peptide |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0844 | Vision |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51718 | G_DYNAMIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF00350 | Dynamin_N |