| Tag | Content |
|---|---|
| Uniprot ID | Q5U3A7 |
| Entrez ID | 492332 |
| Genbank protein ID | AAH85633.1 |
| Genbank nucleotide ID | NM_001007298.1 |
| Ensembl protein ID | ENSDARP00000095031 |
| Ensembl nucleotide ID | ENSDARG00000070801 |
| Gene name | Dynamin-like 120 kDa protein, mitochondrial |
| Gene symbol | opa1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). |
| Sequence | MLRAGSVVTC IACKGLLPSR MGVKFRVPLQ KLHPLSRAIH HRYSANNNPQ RPPHCSAARH 60 YTSLSRLPMR PPKSRSGGHG YQQHRTFWVA RLAARLLKLR YILLGSAVGG GYTAKKTYDE 120 WKEMLPDMSE YTWIVPDFVW ELSENIDLDK LASALPELEE IAKLLPDMEK IGENFTFLKS 180 LLSSETTGES ALRAPDVPPA SAAMADSGDK QFKKSSDKEK VDQLQEELLR TQLKYQRMLE 240 RLEKENKELR KVVLQKDDKG IHQRKVKKSL IDMYSEVLDI LSDYDSNYNT QDHLPRVVVV 300 GDQSAGKTSV LEMIAQARIF PRGSGEMMTR SPVKVTLSEG PHHVAMFKDS SREFDLGKEE 360 DLAALRHEIE LRMRKSVKEG QTVSPETISL SVKGPGIQRM VLVDLPGVIS TVTTGMAADT 420 KETIFSISKA YMQNPNAIIL CIQDGSVDAE RSIVTDLVSQ MDPQGKRTIF VLTKVDLAEK 480 NLASPSRIQQ IVEGKLFPMK ALGYFAVVTG KGSPNESIDS IKDYEEDFFQ NSRLLKDGML 540 KAHQVTTKNL SLAVSDCFWK MVRESVEQQA DAFKASRFNL ETEWKNNYPR LRELDRNELY 600 EKAKNEILDE VISLSQVTPK HWESILQKKL WERVSTHVIE NIYLPAAQTM NSGTFNTTVD 660 IKLKQWTDKQ LPHKALEVAW ETLQEEFARF MAEYKGKDQD DIFDKLKEAV KDESIKRHKW 720 NERAMDSLRV IQHNALEDRS ITDKPQWDAA IQFMEETLQS RLKDTESVIA DMVGPDWKQR 780 WMSWKNRTPE QHTRNETKNE LERLLKLHED HTAYLANDEV TTVRKNLEAR GVEVDPVLIK 840 DTWHQLFRRH FLQKALLHCN LCRRGFYYYQ RHFVDSELEC NDVVLFWRIQ RMLGITANTL 900 RQQLTNTEVR RLEKNVKEVL EDFGEDNEKK VQLITGRRVQ LAEDLKKVRE IQEKLEAFIE 960 ALHKEK 966 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | OPA1 | 524142 | A0A3Q1LJL3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | OPA1 | A0A452EKZ3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | OPA1 | 100059993 | F6Z2C8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | OPA1 | 4976 | O60313 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Opa1 | 74143 | P58281 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | OPA1 | A0A2I3RGT4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Opa1 | 171116 | Q2TA68 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | opa1 | 492332 | Q5U3A7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016021 | integral component of membrane |
| GO:0016020 | membrane |
| GO:0005743 | mitochondrial inner membrane |
| GO:0005758 | mitochondrial intermembrane space |
| GO:0031966 | mitochondrial membrane |
| GO:1901612 | cardiolipin binding |
| GO:0005525 | GTP binding |
| GO:0003924 | GTPase activity |
| GO:0008017 | microtubule binding |
| GO:0070300 | phosphatidic acid binding |
| GO:0006915 | apoptotic process |
| GO:0043009 | chordate embryonic development |
| GO:0003374 | dynamin family protein polymerization involved in mitochondrial fission |
| GO:0046039 | GTP metabolic process |
| GO:0061025 | membrane fusion |
| GO:0097749 | membrane tubulation |
| GO:0000266 | mitochondrial fission |
| GO:0008053 | mitochondrial fusion |
| GO:0070584 | mitochondrion morphogenesis |
| GO:0055015 | ventricular cardiac muscle cell development |
| Keyword ID | Keyword Term |
|---|---|
| KW-0053 | Apoptosis |
| KW-0175 | Coiled coil |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0446 | Lipid-binding |
| KW-0472 | Membrane |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0547 | Nucleotide-binding |
| KW-1185 | Reference proteome |
| KW-0809 | Transit peptide |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51718 | G_DYNAMIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF00350 | Dynamin_N |