Gene: OPA1

Basic information

Tag Content
Uniprot ID A0A3Q1LJL3
Entrez ID 524142
Genbank protein ID
Genbank nucleotide ID NM_001192961.1
Ensembl protein ID ENSBTAP00000059634
Ensembl nucleotide ID ENSBTAG00000019514
Gene name OPA1 mitochondrial dynamin like GTPase
Gene symbol OPA1
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MWRVRQAAVA CEVCQSLVKH SSGTKGSLPL QKLHLVSRSI YHTHHPTLKL QRPQLRMSLQ 60
QFSSLTSLPL RKLKLSPVKY GYQPHRNFWP ARLAARLLKL RYLILGSAVG GGYTAKKTFD 120
QWKDMIPDLS DYKWIVPDIV WEIDEYIDLE KIRKALPNSE DLAKLAPDFD KIAESLSLLK 180
DFFTTGSPGE TAFRATDPGS ESDKRYRKGL LGELILLQQQ IQEHEEEARR AAGQYSTSYA 240
QQKRKVSDKE KIDQLQEELL HTQLKYQRIL ERLEKENKEL RKLVLQKDDK GIHHRKLKKS 300
LIDMYSEVLD VLSDYDASYN TQDHLPRVVV VGDQSAGKTS VLEMIAQARI FPRGSGEMMT 360
RSPVKVTLSE GPHHVALFKD SSREFDLTKE EDLAALRHEI ELRMRKNVKE GCTVSPETIS 420
LNVKGPGLQR MVLVDLPGVI NTVTSGMAPD TKETIFSISK AYMQNPNAII LCIQDGSVDA 480
ERSIVTDLVS QMDPHGRRTI FVLTKVDLAE KNVTSPSRIQ QIIEGKLFPM KALGYFAVVT 540
GKGNSSESIE AIRDYEEEFF QNSKLLKTSM LKAHQVTTRN LSLAVSDCFW KMVRESVEQQ 600
ADSFKATRFN LETEWKNNYP RLRELDRNEL FEKAKNEILD EVISLSQVTP KHWEEILQQS 660
LWERVSTHVI ENIYLPAAQT MNSGTFNTTV DIKLKQWTDK QLPNKAVEVA WETLQEEFSR 720
FMTEPKGKEH DDIFDKLKEA VKEESIKRHK WNDFAEDSLR VIQHNALEDR SISDKQQWDA 780
AIYFMEEALQ ARLKDTENAI ENMVGPDWKK RWLYWKNRTQ EQCVHNETKN ELEKMLKCNE 840
EHPAYLASDE ITTVRKNLES RGVEVDPSLI KDTWHQVYRR HFLKTALNHC NLCRRGFYYY 900
QRHFVDSELE CNDVVLFWRI QRMLAITANT LRQQLTNTEV RRLEKNVKEV LEDFAEDSEK 960
KVKLLTGKRV QLAEDLKKVR EIQEKLDAFI EALHQEK 997

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologOPA1524142A0A3Q1LJL3Bos taurusPredictionMore>>
1:1 orthologOPA1A0A452EKZ3Capra hircusPredictionMore>>
1:1 orthologOPA1100059993F6Z2C8Equus caballusPredictionMore>>
1:1 orthologOPA14976O60313Homo sapiensPredictionMore>>
1:1 orthologOpa174143P58281CPOMus musculusPublicationMore>>
1:1 orthologOPA1A0A2I3RGT4Pan troglodytesPredictionMore>>
1:1 orthologOpa1171116Q2TA68Rattus norvegicusPredictionMore>>
1:1 orthologopa1492332Q5U3A7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005739 mitochondrion
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0342 GTP-binding
KW-0547 Nucleotide-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001401 Dynamin_GTPase
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR033047 Opa1
IPR027417 P-loop_NTPase

PROSITE

PROSITE ID PROSITE Term
PS51718 G_DYNAMIN_2

Pfam

Pfam ID Pfam Term
PF00350 Dynamin_N