| Tag | Content |
|---|---|
| Uniprot ID | Q2TA68; O08681; Q5MPP1; Q5MPP2; Q5QJE9; Q6B435; Q6R611; |
| Entrez ID | 171116 |
| Genbank protein ID | AAV97816.1; AAB51724.1; AAS79791.1; AAR04100.1; AAI11072.1; AAV97815.1; AAT92526.1; |
| Genbank nucleotide ID | NM_133585.3; XM_006248498.1; |
| Ensembl protein ID | ENSRNOP00000002343; ENSRNOP00000002338; |
| Ensembl nucleotide ID | ENSRNOG00000001717 |
| Gene name | Dynamin-like 120 kDa protein, mitochondrial |
| Gene symbol | Opa1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (By similarity). |
| Sequence | MWRAGRAALA CEVCQSLVKH SSGVQRNVPL QKLHLVSRSI YRSHHPALKL QRPQLRTSFQ 60 QFSSLTNLSL HKLKLSPTKY GYQPRRNFWP ARLAARLLKL RYIILGSAVG GGYTAKKTFD 120 EWKDMIPDLS DYKWIVPDFI WEIDEYIDLE KIRKALPSSE DLANFAPDLD KIAESLSLLK 180 DFFTAGTPGE TAFRATDHGS ESDKHYRKVS DKEKIDQLQE ELLHTQLKYQ RILERLEKEN 240 KELRKLVLQK DDKGIHHRKL KKSLIDMYSE VLDVLSDYDA SYNTQDHLPR VVVVGDQSAG 300 KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL FKDSSREFDL TKEEDLAALR 360 HEIELRMRKN VKEGCTVSPE TISLNVKGPG LQRMVLVDLP GVINTVTSGM APDTKETIFS 420 ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPHGR RTIFVLTKVD LAEKNVASPS 480 RIQQIIEGKL FPMKALGYFA VVTGKGNSSE SIEAIREYEE EFFQNSKLLK TSMLKAHQVT 540 TRNLSLAVSD CFWKMVRESV EQQADSFKAT RFNLETEWKN NYPRLRELDR NELFEKAKNE 600 ILDEVISLSQ VTPKHWEEIL QQSLWERVST HVIENIYLPA AQTMNSGTFN TTVDIKLKQW 660 TDKQLPNKAV EVAWETLQDE FSRFMTEPKG KEHDDIFDKL KEAVKEESIK RHKWNDFAED 720 SLRVIQHNAL EDRSISDKQQ WDAAIYFMEE ALQGRLKDTE NAIENMIGPD WKKRWIYWKN 780 RTQEQCVHNE TKNELEKMLK VNDEHPAYLA SDEITTVRKN LESRGVEVDP SLIKDTWHQV 840 YRRHFLKTAL NHCNLCRRGF YYYQRHFIDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN 900 TEVRRLEKNV KEVLEDFAED GEKKVKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK 960 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | OPA1 | 524142 | A0A3Q1LJL3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | OPA1 | A0A452EKZ3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | OPA1 | 100059993 | F6Z2C8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | OPA1 | 4976 | O60313 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Opa1 | 74143 | P58281 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | OPA1 | A0A2I3RGT4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Opa1 | 171116 | Q2TA68 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | opa1 | 492332 | Q5U3A7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005829 | cytosol |
| GO:0030425 | dendrite |
| GO:0031314 | extrinsic component of mitochondrial inner membrane |
| GO:0016021 | integral component of membrane |
| GO:0016020 | membrane |
| GO:0015630 | microtubule cytoskeleton |
| GO:0030061 | mitochondrial crista |
| GO:0005743 | mitochondrial inner membrane |
| GO:0005758 | mitochondrial intermembrane space |
| GO:0031966 | mitochondrial membrane |
| GO:0005741 | mitochondrial outer membrane |
| GO:0005739 | mitochondrion |
| GO:0005654 | nucleoplasm |
| GO:0005886 | plasma membrane |
| GO:1901612 | cardiolipin binding |
| GO:0005525 | GTP binding |
| GO:0003924 | GTPase activity |
| GO:0019900 | kinase binding |
| GO:0008017 | microtubule binding |
| GO:0070300 | phosphatidic acid binding |
| GO:0044877 | protein-containing complex binding |
| GO:0007568 | aging |
| GO:0006915 | apoptotic process |
| GO:0036444 | calcium import into the mitochondrion |
| GO:0071333 | cellular response to glucose stimulus |
| GO:0071456 | cellular response to hypoxia |
| GO:1905232 | cellular response to L-glutamate |
| GO:0090398 | cellular senescence |
| GO:0090102 | cochlea development |
| GO:0046039 | GTP metabolic process |
| GO:0007007 | inner mitochondrial membrane organization |
| GO:0048312 | intracellular distribution of mitochondria |
| GO:0061025 | membrane fusion |
| GO:0097749 | membrane tubulation |
| GO:0000266 | mitochondrial fission |
| GO:0008053 | mitochondrial fusion |
| GO:0000002 | mitochondrial genome maintenance |
| GO:0070584 | mitochondrion morphogenesis |
| GO:0007005 | mitochondrion organization |
| GO:0043066 | negative regulation of apoptotic process |
| GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| GO:0090201 | negative regulation of release of cytochrome c from mitochondria |
| GO:0001843 | neural tube closure |
| GO:0048285 | organelle fission |
| GO:1900078 | positive regulation of cellular response to insulin stimulus |
| GO:1900006 | positive regulation of dendrite development |
| GO:0061003 | positive regulation of dendritic spine morphogenesis |
| GO:0046628 | positive regulation of insulin receptor signaling pathway |
| GO:0010636 | positive regulation of mitochondrial fusion |
| GO:0014042 | positive regulation of neuron maturation |
| GO:0051259 | protein complex oligomerization |
| GO:1904643 | response to curcumin |
| GO:0051602 | response to electrical stimulus |
| GO:0014850 | response to muscle activity |
| GO:0031667 | response to nutrient levels |
| GO:0060041 | retina development in camera-type eye |
| GO:0007601 | visual perception |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0025 | Alternative splicing |
| KW-0053 | Apoptosis |
| KW-0175 | Coiled coil |
| KW-0903 | Direct protein sequencing |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0446 | Lipid-binding |
| KW-0472 | Membrane |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0547 | Nucleotide-binding |
| KW-1185 | Reference proteome |
| KW-0716 | Sensory transduction |
| KW-0809 | Transit peptide |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51718 | G_DYNAMIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF00350 | Dynamin_N |