Gene: OPA1

Basic information

Tag Content
Uniprot ID F6Z2C8
Entrez ID 100059993
Genbank protein ID
Genbank nucleotide ID XM_001500454.5
Ensembl protein ID ENSECAP00000021938
Ensembl nucleotide ID ENSECAG00000024248
Gene name OPA1 mitochondrial dynamin like GTPase
Gene symbol OPA1
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MWRLRRVAVA CEVCQSLVKH SSGMKGSLSL QKLHLVSRSI YHSHHPTLKL QRPQFRTSFQ 60
QFSSLTNLPL RKLKLSPIKY GYQPRRNFWP ARLAARLLKL RYLILGSAVG GGYTAKKTFD 120
QWKDMIPDLS DYKWIVPDIV WEIDEYIDLE KIRKALPNSE DLAKLAPDFD KIVESLSLLK 180
DFFTTGSPGE TAFRATDPGS ESDKPYRKGL LGELILLQQQ IQEHEEEARR AAGQYSTSYA 240
QQKRKVSDKE KIDQLQEELL HTQLKYQRIL ERLEKENKEL RKLVLQKDDK GIHHRKLKKS 300
LIDMYSEVLD VLSDYDASYN TQDHLPRVVV VGDQSAGKTS VLEMIAQARI FPRGSGEMMT 360
RSPVKVTLSE GPHHVALFKD SSREFDLTKE EDLAALRHEI ELRMRKNVKE GCTVSPETIS 420
LNVKGPGLQR MVLVDLPGVI NTVTSGMAPD TKETIFSISK AYMQNPNAII LCIQDGSVDA 480
ERSIVTDLVS QMDPHGRRTI FVLTKVDLAE KNVTSPSRIQ QIIEGKLFPM KALGYFAVVT 540
GKGNSSESIE AIREYEEEFF QNSKLLKTSM LKAHQVTTRN LSLAVSDCFW KMVRESVEQQ 600
ADSFKATRFN LETEWKNNYP RLRELDRNEL FEKAKNEILD EVISLSQVTP KHWEEILQQS 660
LWERVSTHVI ENIYLPAAQT MNSGTFNTTV DIKLKQWTDK QLPNKAVEVA WETLQEEFSR 720
FMTEPKGKEH DDIFDKLKEA VKEESVKRHK WNDFAEDSLR VIQHNALEDR SISDKQQWDA 780
AIYFMEEALQ ARLKDTENAI ENMVGPDWKK RWLYWKNRTQ EQFVHNETKN ELEKMLKCNE 840
EHPAYLASDE ITTVRKNLES RGVEVDPSLI KDTWHQVYRR HFLKTALTHC NLCRRGFYYY 900
QRHFVDSELE CNDVVLFWRI QRMLAITANT LRQQLTNTEV RRLEKNVKEV LEDFAEDSEK 960
KVKLLTGKRV QLAEDLKKVR EIQEKLDAFI EALHQEK 997

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologOPA1524142A0A3Q1LJL3Bos taurusPredictionMore>>
1:1 orthologOPA1A0A452EKZ3Capra hircusPredictionMore>>
1:1 orthologOPA1100059993F6Z2C8Equus caballusPredictionMore>>
1:1 orthologOPA14976O60313Homo sapiensPredictionMore>>
1:1 orthologOpa174143P58281CPOMus musculusPublicationMore>>
1:1 orthologOPA1A0A2I3RGT4Pan troglodytesPredictionMore>>
1:1 orthologOpa1171116Q2TA68Rattus norvegicusPredictionMore>>
1:1 orthologopa1492332Q5U3A7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0031410 cytoplasmic vesicle
GO:0005829 cytosol
GO:0016020 membrane
GO:0015630 microtubule cytoskeleton
GO:0030061 mitochondrial crista
GO:0005758 mitochondrial intermembrane space
GO:0031966 mitochondrial membrane
GO:0005741 mitochondrial outer membrane
GO:0005739 mitochondrion
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:1901612 cardiolipin binding
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0008017 microtubule binding
GO:0070300 phosphatidic acid binding
GO:0006915 apoptotic process
GO:0090398 cellular senescence
GO:0046039 GTP metabolic process
GO:0007007 inner mitochondrial membrane organization
GO:0061025 membrane fusion
GO:0097749 membrane tubulation
GO:0000266 mitochondrial fission
GO:0008053 mitochondrial fusion
GO:0000002 mitochondrial genome maintenance
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0048285 organelle fission
GO:0051259 protein complex oligomerization
GO:0007601 visual perception

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0342 GTP-binding
KW-0547 Nucleotide-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001401 Dynamin_GTPase
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR033047 Opa1
IPR027417 P-loop_NTPase

PROSITE

PROSITE ID PROSITE Term
PS51718 G_DYNAMIN_2

Pfam

Pfam ID Pfam Term
PF00350 Dynamin_N