| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3T853; A0A2J8MFQ9; |
| Entrez ID | 468405 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016932547.1 |
| Ensembl protein ID | ENSPTRP00000085402 |
| Ensembl nucleotide ID | ENSPTRG00000045369 |
| Gene name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 |
| Gene symbol | WFIKKN2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWAPRCRRFW SRWEQVAALL LLLLLLGVPP QSLALPPIRY SHAGICPNDM NPNLWVDAQS 60 TCRRECETDQ ECETYEKCCP NVCGTKSCVA ARYMDVKGKK GPVGMPKEAT CDHFMCLQQG 120 SECDIWDGQP VCKCKDRCEK EPSFTCASDG LTYYNRCYMD AEACSKGITL AVVTCRYHFT 180 WPNTSPPPPE TTMHPTTASP ETPELDMAAP ALLNNPVHQS VTMGETVSFL CDVVGRPRPE 240 ITWEKQLEDR ENVVMRPNHV RGNVVVTNIA QLVIYNAQLQ DAGIYTCTAR NVAGVLRADF 300 PLSVVRGHQA AATSESSPNG TAFPAAECLK PPDSEDCGEE QTRWHFDAQA NNCLTFTFGH 360 CHRNLNHFET YEACMLACMS GPLAACSLPA LQGPCKAYAP RWAYNSQTGQ CQSFVYGGCE 420 GNGNNFESRE ACEESCPFPR GNQRCRACKP RQKLVTSFCR SDFVILGRVS ELTEEPDSGR 480 ALVTVDEVLK DEKMGLKFLG REPLEVTLLH VDWACPCPNV TVSEMPLIIM GEVDGGMAML 540 RPDSFVGASS ARRVRKLREV MHKKTCDVLK EFLGLH 576 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN2 | 491086 | E2RSS4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 102178659 | A0A452FFV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 124857 | Q8TEU8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 278507 | Q7TQN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN2 | 468405 | A0A2I3T853 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | F1RTB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WFIKKN2 | 100345789 | G1SD75 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 287631 | D3Z9K5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR018933 | Netrin_module_non-TIMP |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033639 | WFIKKN2 |