| Tag | Content |
|---|---|
| Uniprot ID | G1SD75 |
| Entrez ID | 100345789 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002719104.3 |
| Ensembl protein ID | ENSOCUP00000000344 |
| Ensembl nucleotide ID | ENSOCUG00000000391 |
| Gene name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 |
| Gene symbol | WFIKKN2 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWALGCRRRL WTPWGLLLLL LGVPPRGLAP PPIRYSHAGV CPNDMNPNLW VDAQSTCKRE 60 CETDQECETY EKCCPNVCGT KSCVAARYMD VRGKKGPVGM PKEATCDHFM CLQQGSECDI 120 WDGQPVCKCR DRCEKEPSFT CASDGLTYYN RCYMDAEACS KGITLAVVTC RYHFTWPNTS 180 PPPPETTVHP TTASPETPGL DMAAPALLNH PVHQSVTVGE TVSFLCDVVG RPRPEISWEK 240 QLEDRENVVM WPNHVRGNVV VTNIAQLVIY NAQPQDAGIY TCTARNAAGV LRADFPLSVV 300 RGGQAAATSE SSPNGTAFPA AECLQPPDSE DCGEEQTRWH FDAQANNCLT FTFGHCHRNL 360 NHFETYEACV LACMSGPLAV CSLPALQGPC KAYAPRWAYN SQTGQCQSFV YGGCEGNGNN 420 FESREACEES CPVPRGNQRC RACKPRQKLV TSFCRSDFVI LGRVSELTEE PDSGRALVTV 480 DEVLKDDKMG LKFLGREPLE VTLLHVDWAC PCPNVTAGET PLILMGDVEG GMAMLRPDSF 540 VGAASARRVR KLHEVVHKKT CDVLKELLAL P 571 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN2 | 491086 | E2RSS4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 102178659 | A0A452FFV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 124857 | Q8TEU8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 278507 | Q7TQN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN2 | 468405 | A0A2I3T853 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | F1RTB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WFIKKN2 | 100345789 | G1SD75 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 287631 | D3Z9K5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR018933 | Netrin_module_non-TIMP |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033639 | WFIKKN2 |