| Tag | Content |
|---|---|
| Uniprot ID | F1RTB4 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000018606 |
| Ensembl nucleotide ID | ENSSSCG00000017557 |
| Gene name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 |
| Gene symbol | WFIKKN2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWAPGRRQSP AGGRWQHCWG QVAALLLLLL GVPPRGLALP PIRYSHAGIC PNDMNPNLWV 60 DAQSTCKREC ETDQECETYE KCCPNVCGTK SCVAARYMDV KGKKGPVGMP KEATCDHFMC 120 LQQGSECDIW DGQPVCKCRD RCEKEPSFTC ASDGLTYYNR CYMDAEACSK GITLAVVTCR 180 YHFTWPNTSP PPPETTVHPT TASPETPGLD TAAPALLNHP AHQSVTVGET VSFLCDVVGR 240 PRPEITWEKQ LEDRENVVMG PNHVRGNVVV TNIAQLVIYN AQPQDAGIYT CTARNAAGVL 300 RADFPLSVVR GGQPSATAES SLNGTAFPAA ECLKPPDSED CGEEQTRWHF DAQANNCLTF 360 TFGHCHRNRN HFETYEACML ACMRGPLAVC SLPALQGPCK AYAPRWAYNS QTGQCQSFVY 420 GGCEGNGNNF ESREACEESC PFPRGNQRCR ACKPRQKLVT SFCRSDFVIL GRVSELTEEP 480 DSGRALVTVD EVLKDEKMGL RFLGREPLEV TLLHVDWTCP CPNVTVGETP LIIMGEVDGG 540 MAMLRPDSFV GASSTRRVRK LREVMHKKTC DVLKEFPGLQ |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN2 | 491086 | E2RSS4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 102178659 | A0A452FFV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 124857 | Q8TEU8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 278507 | Q7TQN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN2 | 468405 | A0A2I3T853 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | F1RTB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WFIKKN2 | 100345789 | G1SD75 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 287631 | D3Z9K5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR018933 | Netrin_module_non-TIMP |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033639 | WFIKKN2 |