| Tag | Content |
|---|---|
| Uniprot ID | D3Z9K5 |
| Entrez ID | 287631 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_220855.9; XM_017604128.1; |
| Ensembl protein ID | ENSRNOP00000003784 |
| Ensembl nucleotide ID | ENSRNOG00000002831 |
| Gene name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2 |
| Gene symbol | Wfikkn2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWAPGHHRFW FHWGLLLLLL LGAPLRGLAL PHIRYSHAGI CPNDMNPNLW VDAQSTCKRE 60 CETDQECETY EKCCPNVCGT KSCVAARYMD VKGKKGPVGM PKEATCDHFM CLQQGSECDI 120 WDGQPVCKCK DRCEKEPSFT CASDGLTYYN RCYMDAEACS KGVTLSVVTC RYHFTWPNTS 180 PPPPETTVHP TTASPETLGL DMAAPALLNH PVHQSVTVGE TVSFLCDVVG RPRPELTWEK 240 QLEDRENVVM RPNHVRGNVV VTNIAQLVIY NAQPQDAGIY TCTARNVAGV LRADFPLSVV 300 RGGQARATSE SSLNGTAFPA TECLKPPDSE DCGEEQTRWH FDAQANNCLT FTFGHCHRNL 360 NHFETYEACM LACMSGPLAT CSLPALQGPC KAYVPRWAYN SQTGLCQSFV YGGCEGNGNN 420 FESREACEES CPFPRGNQNC RACKPRQKLV TSFCRSDFVI LGRVSELTEE PDSGRALVTV 480 DEVLKDEKMG LKFLGREPLE VTLLHVDWTC PCPNVTVGET PLIIMGEVEG GMAMLKPDSF 540 VGASSTRRVR KLREVMYKKT CDVLKDFLGL Q 571 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN2 | 491086 | E2RSS4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 102178659 | A0A452FFV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 124857 | Q8TEU8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 278507 | Q7TQN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN2 | 468405 | A0A2I3T853 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | F1RTB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WFIKKN2 | 100345789 | G1SD75 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 287631 | D3Z9K5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR018933 | Netrin_module_non-TIMP |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033639 | WFIKKN2 |