Gene: Wfikkn2

Basic information

Tag Content
Uniprot ID D3Z9K5
Entrez ID 287631
Genbank protein ID
Genbank nucleotide ID XM_220855.9; XM_017604128.1;
Ensembl protein ID ENSRNOP00000003784
Ensembl nucleotide ID ENSRNOG00000002831
Gene name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2
Gene symbol Wfikkn2
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MWAPGHHRFW FHWGLLLLLL LGAPLRGLAL PHIRYSHAGI CPNDMNPNLW VDAQSTCKRE 60
CETDQECETY EKCCPNVCGT KSCVAARYMD VKGKKGPVGM PKEATCDHFM CLQQGSECDI 120
WDGQPVCKCK DRCEKEPSFT CASDGLTYYN RCYMDAEACS KGVTLSVVTC RYHFTWPNTS 180
PPPPETTVHP TTASPETLGL DMAAPALLNH PVHQSVTVGE TVSFLCDVVG RPRPELTWEK 240
QLEDRENVVM RPNHVRGNVV VTNIAQLVIY NAQPQDAGIY TCTARNVAGV LRADFPLSVV 300
RGGQARATSE SSLNGTAFPA TECLKPPDSE DCGEEQTRWH FDAQANNCLT FTFGHCHRNL 360
NHFETYEACM LACMSGPLAT CSLPALQGPC KAYVPRWAYN SQTGLCQSFV YGGCEGNGNN 420
FESREACEES CPFPRGNQNC RACKPRQKLV TSFCRSDFVI LGRVSELTEE PDSGRALVTV 480
DEVLKDEKMG LKFLGREPLE VTLLHVDWTC PCPNVTVGET PLIIMGEVEG GMAMLKPDSF 540
VGASSTRRVR KLREVMYKKT CDVLKDFLGL Q 571

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWFIKKN2491086E2RSS4Canis lupus familiarisPredictionMore>>
1:1 orthologWFIKKN2102178659A0A452FFV0Capra hircusPredictionMore>>
1:1 orthologWFIKKN2124857Q8TEU8Homo sapiensPredictionMore>>
1:1 orthologWfikkn2278507Q7TQN3CPOMus musculusPublicationMore>>
1:1 orthologWFIKKN2468405A0A2I3T853Pan troglodytesPredictionMore>>
1:1 orthologWFIKKN2F1RTB4Sus scrofaPredictionMore>>
1:1 orthologWFIKKN2100345789G1SD75Oryctolagus cuniculusPredictionMore>>
1:1 orthologWfikkn2287631D3Z9K5Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0048019 receptor antagonist activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0050431 transforming growth factor beta binding
GO:0048747 muscle fiber development
GO:0043392 negative regulation of DNA binding
GO:0032091 negative regulation of protein binding
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0060021 roof of mouth development
GO:0001501 skeletal system development
GO:0007179 transforming growth factor beta receptor signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR020901 Prtase_inh_Kunz-CS
IPR008993 TIMP-like_OB-fold
IPR008197 WAP_dom
IPR033639 WFIKKN2

PROSITE

PROSITE ID PROSITE Term
PS00280 BPTI_KUNITZ_1
PS50279 BPTI_KUNITZ_2
PS50835 IG_LIKE
PS51465 KAZAL_2
PS50189 NTR
PS51390 WAP

Pfam

Pfam ID Pfam Term
PF07679 I-set
PF00014 Kunitz_BPTI
PF01759 NTR
PF00095 WAP